Department of Molecular Biosciences

Angelastro, James M.
Assistant Professor
752-1591
jmangelastro@ucdavis.edu

Cell biology, signal transduction, neurochemistry, gene expression, apoptosis, and neurobiology.

Buckpitt, Alan R.
Professor/ Chair of Pharmacology & Toxicology Graduate Group
752-7674
arbuckpitt@ucdavis.edu

Metabolic activation and detoxication of environmental chemicals that produce tissue selective cytotoxicity, particularly of the lung. Mechanisms for cellular degeneration especially with regard to the role of reactive metabolites. Pharmacokinetics, xenobiotic metabolism, lung toxicity. Alterations of pulmonary cell homeostasis assessed by micro array and proteomic approaches

Cortopassi, Gino A.
Professor
754-9665
gacortopassi@ucdavis.edu

Mitochondrial biochemistry genetics, disease and toxicology. Mutagenesis and age-related degenerative disease. Application of molecular genetics to veterinary medicine.

Fascetti, Andrea J.
Associate Professor /Nutrition Service Chief
754-6974 /752-7902 (VMTH)
ajfascetti@ucdavis.edu

Nutrition and metabolism in companion animals (dogs and cats); trace mineral requirements in cat; the influence of trace minerals on reproductive efficiency in cats; taurine metabolism in the dog; improvement of pet foods; veterinary clinical nutrition-the use of nutrition in the management and prevention of disease.

Feng, Wei
Assistant Researcher
752-2174
wfeng@ucdavis.edu

Intracellular ion channels, especially ryanodine-sensitive Ca2+ release channel (RyRs) of skeletal and cardiac sarcoplasmic reticulum.

Giulivi, Cecilia
Associate Professor
754-6373
cgiulivi@ucdavis.edu

Biosynthesis of nitric oxide in mitochondria, oxygen and nitrogen free radical biochemistry and chemistry in in vitro and in vivo model systems, proteomics of aging and oxidative damage of mitochondria, protoeomics of colon cancer, and signal transduction pathways in osteoporosis.

Goth, Sam
Associate Specialist
752-5022
srgoth@ucdavis.edu

Molecular mechanism by which BDEs and thimerosal induce immunotoxicity.

Hansen, Robert J.
Professor and Department Chair
752-3173 /752-1059
rjhansen@ucdavis.edu

Mechanism of insulin and other hormones on turnover of specific proteins in animals; metabolic nutrition; physiological chemistry/biochemistry; metabolic control in animals. Lipoprotein metabolism in laying hens.

Lamé, Michael
Associate Researcher
752-1454
mwlame@ucdavis.edu

Mechanism(s) involved in the monocrotaline model of pulmonary hypertension with a present focus on determining if electrophilic insult directed at specific proteins can be linked to the observed pathology. Development of synthetic protocols for obtaining non-commercially available radiolabeled compounds, production of antibodies for the isolation and detection of pyrrole adducted macromolecules, development of 2D proteome analysis protocols coupled with MALDI-MS for the identification of adducted proteins, and the application of various affinity purification protocols to isolate adducted materials from complex biological matrices.

Morris, James G.
Professor Emeritus
752-3183
jgmorris@ucdavis.edu

Nutrition and metabolism of companion animals (cats and dogs), their requirements for essential nutrients, especially amino acids, taurine, vitamin D and minerals; comparative nutrition of animals.

Mount, Michael E.
Associate Professor
754-8248
memount@ucdavis.edu

Veterinary clinical toxicology in livestock and companion animals and development of analytical methods for drugs and poisons affecting the veterinary profession. Alternative veterinary medicine, especially acupuncture.

North, Thomas
Professor /Prof in Residence, Ctr for Comparative Medicine
752-3414
twnorth@ucdavis.edu

Antiviral drugs and viral resistance to AIDS therapy in simian, feline and human immunodeficiency viruses (SIV, FIV and HIV).

Pessah, Isaac N.
Professor/ Director, Ctr for Children’s Environmental Health & Disease Prevention
752-6696
inpessah@ucdavis.edu

Molecular and cellular mechanisms regulating cellular Ca2+ signaling. The structure, function, pharmacology of intracellular calcium release channels of sarcoplasmic and endoplasmic reticulum in striated muscle and neurons. Mechanisms by which xenobiotics alter cellular calcium signaling and calcium-dependent processes and its impact on regulation of cell growth and differentiation. Environmental etiology of autism.

Poppenga, Robert
Professor of Clinical Diagnostic Toxicology at CAHFS
752-8125
rhpoppenga@ucdavis.edu

Diagnostic toxicology, wildlife and environmental toxicology, especially heavy metal poisoning.

Puschner, Birgit
Associate Prof of Clinical Diagnostic Toxicology at CAHFS
752-1154
bpuschner@ucdavis.edu

Diagnostic toxicology.

Raabe, Otto G.
Professor Emeritus
2-7754 /2-1059
ograabe@ucdavis.edu

Inhalation toxicology; pharmacokinetic models of dosimetry for toxicants; dose response models and risk assessment; environmental health; air pollution; radiation biophysics; aerosol science; health physics; occupational health; radionuclide toxicology, radiological health.

Ramsey, Jon J.
Assistant Professor
754-8122
jjramsey@ucdavis.edu

Dietary restriction and energy expenditure; aging, oxidative stress and energy restriction; mito-chondrial proton leak; regulation of food intake; energy metabolism.

Rogers, Quinton R.
Professor
752-3086
qrrogers@ucdavis.edu

Experimental nutrition and metabolism; influence of amino acids on control of food intake; amino acid nutrition and metabolism in general and in the cat and dog. Taurine nutrition and metabolism.

Segall, Henry J.
Professor
752-6173
hjsegall@ucdavis.edu

Metabolic activation, detoxifiction, covalent binding, cytotoxicity and genotoxicity of naturally occurring compounds. Pulmonary hypertension induced by monocrotaline. Lipid peroxidation products and their associated cytotoxicity.

Shultz, Michael
Assistant Project Scientist/Director,Microarray Facility
752-1178
mashultz@ucdavis.edu

Microarray facility:
Leopard@ucdavis.edu

Website: http://array.ucdavis.edu/facilities.jsp

Respiratory toxicology, catalytic activities of cytochrome P450 2F2, microarray and mass spec techniques, alternations in the transcriptome of rat lung, toxicogenomics.

Tan, Guolin
Assistant Researcher
754-9341
gltan@ucdavis.edu

Cancer, molecular biology, muscular dystrophy, and otolaryngology.

Vulliet, P. Richard
Professor
752-7409
prvulliet@ucdavis.edu

Biochemistry and molecular biology of the adrenergic nervous system; signal transduction; characterization of the response to acute and chronic stress using molecular, cellular, biochemical and pharmacological techniques; also, elucidation of pharmacodynamic and pharmacokinetic properties of commonly used therapeutic agents in research and clinical cases.

Witschi, Hanspeter
Professor Emeritus /Research Professor
752-0915/ 752-1059
hpwitschi@ucdavis.edu

General toxicology, with particular interest in carcinogenesis and lung disease; forensic pathology. Pathology; medicine; pharmacology; risk assessment; lung disease; air pollution; lung cancer.

Wong, Alice
Assistant Researcher
754-9341
awong@ucdavis.edu

Mitochondria and neurodegenerative disease.

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Faculty Research Interests

Angelastro, James M. Assistant Professor 752-1591 jmangelastro@ucdavis.edu	Cell biology, signal transduction, neurochemistry, gene expression, apoptosis, and neurobiology.

Buckpitt, Alan R. Professor/ Chair of Pharmacology & Toxicology Graduate Group 752-7674 arbuckpitt@ucdavis.edu	Metabolic activation and detoxication of environmental chemicals that produce tissue selective cytotoxicity, particularly of the lung. Mechanisms for cellular degeneration especially with regard to the role of reactive metabolites. Pharmacokinetics, xenobiotic metabolism, lung toxicity. Alterations of pulmonary cell homeostasis assessed by micro array and proteomic approaches

Cortopassi, Gino A. Professor 754-9665 gacortopassi@ucdavis.edu	Mitochondrial biochemistry genetics, disease and toxicology. Mutagenesis and age-related degenerative disease. Application of molecular genetics to veterinary medicine.

Fascetti, Andrea J. Associate Professor /Nutrition Service Chief 754-6974 /752-7902 (VMTH) ajfascetti@ucdavis.edu	Nutrition and metabolism in companion animals (dogs and cats); trace mineral requirements in cat; the influence of trace minerals on reproductive efficiency in cats; taurine metabolism in the dog; improvement of pet foods; veterinary clinical nutrition-the use of nutrition in the management and prevention of disease.

Feng, Wei Assistant Researcher 752-2174 wfeng@ucdavis.edu	Intracellular ion channels, especially ryanodine-sensitive Ca2+ release channel (RyRs) of skeletal and cardiac sarcoplasmic reticulum.

Giulivi, Cecilia Associate Professor 754-6373 cgiulivi@ucdavis.edu	Biosynthesis of nitric oxide in mitochondria, oxygen and nitrogen free radical biochemistry and chemistry in in vitro and in vivo model systems, proteomics of aging and oxidative damage of mitochondria, protoeomics of colon cancer, and signal transduction pathways in osteoporosis.

Goth, Sam Associate Specialist 752-5022 srgoth@ucdavis.edu	Molecular mechanism by which BDEs and thimerosal induce immunotoxicity.

Hansen, Robert J. Professor and Department Chair 752-3173 /752-1059 rjhansen@ucdavis.edu	Mechanism of insulin and other hormones on turnover of specific proteins in animals; metabolic nutrition; physiological chemistry/biochemistry; metabolic control in animals. Lipoprotein metabolism in laying hens.

Lamé, Michael Associate Researcher 752-1454 mwlame@ucdavis.edu	Mechanism(s) involved in the monocrotaline model of pulmonary hypertension with a present focus on determining if electrophilic insult directed at specific proteins can be linked to the observed pathology. Development of synthetic protocols for obtaining non-commercially available radiolabeled compounds, production of antibodies for the isolation and detection of pyrrole adducted macromolecules, development of 2D proteome analysis protocols coupled with MALDI-MS for the identification of adducted proteins, and the application of various affinity purification protocols to isolate adducted materials from complex biological matrices.

Morris, James G. Professor Emeritus 752-3183 jgmorris@ucdavis.edu	Nutrition and metabolism of companion animals (cats and dogs), their requirements for essential nutrients, especially amino acids, taurine, vitamin D and minerals; comparative nutrition of animals.

Mount, Michael E. Associate Professor 754-8248 memount@ucdavis.edu	Veterinary clinical toxicology in livestock and companion animals and development of analytical methods for drugs and poisons affecting the veterinary profession. Alternative veterinary medicine, especially acupuncture.

North, Thomas Professor /Prof in Residence, Ctr for Comparative Medicine 752-3414 twnorth@ucdavis.edu	Antiviral drugs and viral resistance to AIDS therapy in simian, feline and human immunodeficiency viruses (SIV, FIV and HIV).

Pessah, Isaac N. Professor/ Director, Ctr for Children’s Environmental Health & Disease Prevention 752-6696 inpessah@ucdavis.edu	Molecular and cellular mechanisms regulating cellular Ca2+ signaling. The structure, function, pharmacology of intracellular calcium release channels of sarcoplasmic and endoplasmic reticulum in striated muscle and neurons. Mechanisms by which xenobiotics alter cellular calcium signaling and calcium-dependent processes and its impact on regulation of cell growth and differentiation. Environmental etiology of autism.

Poppenga, Robert Professor of Clinical Diagnostic Toxicology at CAHFS 752-8125 rhpoppenga@ucdavis.edu	Diagnostic toxicology, wildlife and environmental toxicology, especially heavy metal poisoning.

Puschner, Birgit Associate Prof of Clinical Diagnostic Toxicology at CAHFS 752-1154 bpuschner@ucdavis.edu	Diagnostic toxicology.

Raabe, Otto G. Professor Emeritus 2-7754 /2-1059 ograabe@ucdavis.edu	Inhalation toxicology; pharmacokinetic models of dosimetry for toxicants; dose response models and risk assessment; environmental health; air pollution; radiation biophysics; aerosol science; health physics; occupational health; radionuclide toxicology, radiological health.

Ramsey, Jon J. Assistant Professor 754-8122 jjramsey@ucdavis.edu	Dietary restriction and energy expenditure; aging, oxidative stress and energy restriction; mito-chondrial proton leak; regulation of food intake; energy metabolism.

Rogers, Quinton R. Professor 752-3086 qrrogers@ucdavis.edu	Experimental nutrition and metabolism; influence of amino acids on control of food intake; amino acid nutrition and metabolism in general and in the cat and dog. Taurine nutrition and metabolism.

Segall, Henry J. Professor 752-6173 hjsegall@ucdavis.edu	Metabolic activation, detoxifiction, covalent binding, cytotoxicity and genotoxicity of naturally occurring compounds. Pulmonary hypertension induced by monocrotaline. Lipid peroxidation products and their associated cytotoxicity.

Shultz, Michael Assistant Project Scientist/Director,Microarray Facility 752-1178 mashultz@ucdavis.edu Microarray facility: Leopard@ucdavis.edu Website: http://array.ucdavis.edu/facilities.jsp	Respiratory toxicology, catalytic activities of cytochrome P450 2F2, microarray and mass spec techniques, alternations in the transcriptome of rat lung, toxicogenomics.

Tan, Guolin Assistant Researcher 754-9341 gltan@ucdavis.edu	Cancer, molecular biology, muscular dystrophy, and otolaryngology.

Vulliet, P. Richard Professor 752-7409 prvulliet@ucdavis.edu	Biochemistry and molecular biology of the adrenergic nervous system; signal transduction; characterization of the response to acute and chronic stress using molecular, cellular, biochemical and pharmacological techniques; also, elucidation of pharmacodynamic and pharmacokinetic properties of commonly used therapeutic agents in research and clinical cases.

Witschi, Hanspeter Professor Emeritus /Research Professor 752-0915/ 752-1059 hpwitschi@ucdavis.edu	General toxicology, with particular interest in carcinogenesis and lung disease; forensic pathology. Pathology; medicine; pharmacology; risk assessment; lung disease; air pollution; lung cancer.

Wong, Alice Assistant Researcher 754-9341 awong@ucdavis.edu	Mitochondria and neurodegenerative disease.

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