William R. Pritchard Veterinary Medical Teaching Hospital

Regenerative Medicine

Research

Greg Ferraro
Greg Ferraro, DVM, Director, Center for Equine Health
Dr. Ferraro is the Director of the UC Davis Center for Equine Health, and has contributed to the health and well-being of horses through clinical practice, veterinary medical education and research. He has authored more than 50 scientific papers and articles on equine health. As a racehorse surgeon, he pioneered the adaptation of arthroscopic surgical techniques established in human medicine to equine veterinary medicine. At the Center for Equine Health, he has engaged faculty members and resident veterinarians who represent the spectrum of basic and clinical research disciplines, and he has established research initiatives that include the Bernice Barbour Communicable Disease Laboratory and the CEH-Stem Cell Regenerative Medicine Research Group.

Keith Baar
Keith Baar, PhD
Dr Baar's research is focused on determining the molecular mechanisms underlying the physiological and functional adaptations of muscle to exercise. To delve deeper into the molecular mechanisms underlying the effects of exercise, Keith's lab is currently engineering muscle tissue outside the body with a particular interest in applying this model towards understanding muscle physiology and function. His recent work has used this model to show that the physiologic differences between fast and slow muscles can be retained in muscles engineered in vitro and has also used machines to alter muscle phenotype using different patterns of electrical stimulation. He is now using these techniques to study the effect of genetic manipulation on muscle function in an attempt to identify genes that could be targeted to improve performance or treat obesity, diabetes, and frailty.

Dori Borjesson
Dori Borjesson, DVM, PhD, Diplomate ACVP, Associate Professor
Dr. Borjesson has clinical expertise in clinical pathology and cell biology. Research focus on hematopoiesis and mesenchymal stem cells derived from cord blood, umbilical cord tissue, adipose tissue and bone marrow. Our research emphasizes how Mesenchymal stem cells 1) alter the immune system (immunomodulation) and 2) function in an inflammatory environment.

Larry Galuppo
Larry Galuppo, DVM, Diplomate ACVS, Professor and Chief – Equine Surgery
Dr. Galuppo's clinical expertise is in equine orthopedic surgery including tendon and ligament injuries, and joint disease, with special interest in traumatology and fracture repair. His research emphasis is on biomechanics of fracture generation, implant design and fracture repair, with focus in novel healing methods for musculoskeletal injuries utilizing regenerative medicine technology.

Kei Hayashi
Kei Hayashi, DVM, PhD, Diplomate ACVS
Dr. Hayashi graduated from the University of Tokyo, Veterinary Medical Science in 1993 with a focus in small animal medicine and surgery and a post-doctoral degree in Veterinary Medical Science in 1997. Concurrently he also completed a post-doctoral degree in Comparative Biomedical Sciences at the University of Wisconsin. He then completed a fellowship in Small Animal Medicine and Surgery and a residency in Small Animal Surgery at the University of Wisconsin in 2003. He is a member of the orthopedic surgery service at the University of California - Davis. His areas of expertise include all aspects of orthopedic surgery and minimally invasive surgery. Dr. Hayashi has numerous research publications, and has contributed to text book chapters in the field of small animal surgery.

Kent Leach
Kent Leach, PhD, Department of Biomedical Engineering
Dr. Leach's expertise is in the synthesis and use of biomedical derived from natural and synthetic materials, cell-to-cell interactions, controlled delivery of pharmacological molecules, and in vivo imaging. Research focus on the engineering and regeneration of replacement tissue. Dr. Leach's major research interests include cell-instructive biomaterials, understanding the local biophysical microenvironment, drug and gene delivery, and application of in vivo imaging tools to monitor tissue formation.

Chris Murphy
Chris Murphy, DVM, PhD
Dr. Murphy has appointments as a professor of comparative ophthalmology in the School of Medicine's Department of Ophthalmology and Vision Sciences, and in the School of Veterinary Medicine's Department of Surgical and Radiological Sciences. Dr. Murphy is investigating: 1) modulation of cell behaviors by biophysical cues, with relevance to the design of improved cell culture ware, surgical implants and understanding disease processes; 2) development of improved organ preservation media, by which to markedly extend the length of time an intact organ can be stored; 3) engineering-inspired approaches to "engineer" a wound bed to promote healing; 4) optical performance in animals that evolved in response to challenging environmental conditions

Sean Owens
Sean Owens, DVM, Diplomate ACVP, Assistant Professor
Following an internship in small animal medicine and surgery, he completed a fellowship in small animal transfusion medicine at the University of Pennslyvania's Penn Animal Blood Bank. Dr. Owens completed his residency training in clinical pathology at UC Davis in 2004, and worked as a clinical pathologist with IDEXX Reference Laboratories, Inc., for two years prior to coming back to UC Davis. His research interests include red cell compatibility issues, blood banking, and transfusion medicine.

Sarah Puchalski
Sarah Puchalski, DVM, Diplomate ACVR
Dr. Puchalski attended veterinary school at the University of Saskatchewan and completed her residency training at the University of California, Davis. She is currently an assistant professor of diagnostic imaging, and her interests include cross-sectional imaging of the equine distal limb, and imaging of musculoskeletal disease. Dr. Puchalski has clinical expertise in cross-sectional imaging (CT and MRI) with an emphasis on equine lameness diagnosis. Research focus on the implementation of novel cross-sectional imaging techniques in equine orthopedics.

Susan Stover
Susan Stover, DVM, PhD, Diplomate ACVS
Dr. Stover focuses her research on the prevention of musculoskeletal injuries in equine athletes. Key contributions to the safety and welfare of the horse include development of joint fluid sampling techniques, discovery and characterization of lesions that predispose racehorses to catastrophic injuries, and elucidation of risk factors for injuries in racehorses. Current efforts emphasize the understanding of how training and injury affect fracture mechanics and fracture propagation in bones, as well as the effects of race surface materials and shoes on hoof and fetlock biomechanics and thus propensity for injury. She received the 2007 Pfizer Animal Health Award for Research Excellence, which recognizes research innovation and productivity of national significance. Her work has led to new recommendations for training methods, horseshoe types and, most recently, racetrack surfaces. Stover earned her veterinary degree from Washington State University and completed an equine surgery internship and residency at UC Davis, where she teaches veterinary students, residents and graduate students about equine musculoskeletal biomechanics, anatomy, and pathology.

Beverly Sturges
Beverly Sturges, DVM, Diplomate ACVIM (Neurology)
Dr. Sturges completed a BS with high honors from Andrews University in 1980. From 1980 to 1981, Dr. Sturges was a graduate researcher in immunoparasitology. She received her DVM degree cum laude from Oregon State University in 1986. She completed a neurology/neurosurgery residency at the Veterinary Medical Teaching Hospital at the University of California – Davis in 1998. That same year she achieved American College of Veterinary Internal Medicine (Neurology) certification. From 1998 to the present, she has held a Lecturer position in Neurology/Neurosurgery at the UC Davis' VMTH. Sturges' research interests include brain tumors, and intracranial and spinal neurosurgery.

Jamie Textor
Jamie Textor, DVM, Diplomate ACVS
Dr. Textor is an equine surgeon now in pursuit of a PhD in the Tablin Lab at UC Davis. Her areas of research will cover the range of platelets in both healing and disease processes: from platelet-rich plasma as used to aid tissue repair, to platelet-induced inflammation after exposure to air pollution or endotoxin. She graduated in 1998 from Colorado State University, complete an internship in Ocala, Florida, a surgery residency at Cornell University, and became a Diplomate of the American College of Veterinary Surgeons in 2003. She has served as an equine surgeon and instructor at Massey University in New Zealand, Oregon State University, University of Sydney, and UC Davis.

Martin Vidal
Martin Vidal, BVSc, MS, PhD, Diplomate ACVS
Dr. Vidal is a professor of equine surgery in the department of Surgical and Radiological Sciences at UC Davis, School of Veterinary Medicine. His primary research interests are equine orthopedic diseases with a focus on the biology and application of equine somatic stem cells for regenerative tissue repair. Dr. Vidal is currently investigating growth, differentiation, and senescence characteristics of equine somatic stem cells and their response to tissue targeting and growth factor-induced functional enhancement. His long-term goal is to combine his clinical interests in treating predominantly equine athletic injuries of tendons and ligaments with tissue engineering approaches developed through collaborative research.

Clare Yellowley
Clare Yellowley, PhD
Dr. Yellowley is an Associate Professor in the Department of Anatomy, Physiology and Cell Biology at UC Davis School of Veterinary Medicine. Recently, she has begun to study Mesenchymal stem cells, which are believed to represent a store of potential progenitors for tissue repair and regeneration. The focus of her research is to understand the role of stem cell recruitment and differentiation in bone development, maintenance and repair, including fracture repair. Dr. Yellowley is investigating whether the hypoxic environment at a fracture site stimulates the release of chemotactic factors from bone cells and subsequent migration of MSCs to that site to aid fracture repair. In addition, she is interested in the effects of decreased oxygen on the subsequent differentiation of stem cells down the osteogenic lineage.