Clinical Studies and Outcomes

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Clinical Studies and Outcomes

The research program in Dentistry and Oral Surgery focuses on clinical research in veterinary dentistry in order to improve our understanding of oral disease processes, to expand upon available treatment options, and to optimize patient care. Investigational procedures are rarely performed on patients; rather, the utilization of patient material for clinical research is optimized by keeping comprehensive records, collecting specimens and samples, and ensuring adequate follow-up.

Current Studies Include the Following:

  • Comparative oral and dental pathology, including tumors, cysts and other lesions in the oral cavities of different species
  • Oral diagnostic imaging in the dog and cat, including dental radiology and cone beam computed tomography
  • Diagnostic imaging of maxillofacial trauma in dogs and cats
  • Clinical dentistry in rabbits and rodents, particularly the management of malocclusion
  • Reconstruction following maxillofacial surgery
  • Regenerative approach to mandibular reconstruction: surgical management, systemic progenitor cell recruitment, and outcome studies
  • Stem cell therapy for cats with chronic gingivostomatitis as an immunomodulatory treatment
  • Temporomandibular joint disorders: comparative aspects, computed tomographic studies, treatments and outcomes
  • Additive manufacturing (3D printing) as a surgical planning modality for oral and maxillofacial disorders

Selected Recent Publications

2011

•    Arzi B, Murphy B, Baumgarth N, Vapniarsky N, Nemec A, Naydan D, Cox DP, Verstraete FJM. 2011 Analysis of immune cells within the healthy oral mucosa of specific pathogen free cats. Anatomia, Histologia, Embryologia 40(1): 1-10

•    Fiani N, Verstraete FJM, Kass PH, Cox DP. 2011 Clinicopathologic characterization of odontogenic tumors and focal fibrous hyperplasia in dogs: 152 cases (1995–2005). Journal of the American Veterinary Medical Association 238(4): 495-500

•    Fiani N, Arzi B, Johnson EG, Murphy B, Verstraete FJM. 2011 Osteoma of the oral and maxillofacial region in cats: 7 cases (1999 - 2009). Journal of the American Veterinary Medical Association 238(11): 1470-1475

•    Arzi B, Murphy B, Nemec A, Vapniarsky N, Naydan DK, Verstraete FJM. 2011 Expression of cytokeratins in the epithelium of canine odontogenic tumours. Journal of Comparative Pathology 145(2-3): 345-351

•    Verstraete FJM, Zin BP, Kass PH, Cox DP, Jordan RC. 2011 Clinical signs and histologic findings in dogs with odontogenic cysts: 41 cases (1995-2010). Journal of the American Veterinary Medical Association 239(11): 1470-1476

•    Arzi B, Verstraete FJM. 2011 Repair of a bifid nose combined with a cleft of the primary palate in a 1-year-old dog. Veterinary Surgery 40(7): 865-869

2012

•    Nemec A, Jerin A, Zdovc I, Budefeld T, Verstraete FJM, Erzen D, Sentjurc M, Petelin M, Hitti T, Pavlica Z. 2012 Early systemic inflammatory response in mice after a single oral gavage with live Escherichia coli is evidenced by increased TNF-alpha and nitric oxide production. Research in Veterinary Science 92: 401-407

•    Nemec A, Arzi B, Murphy B, Kass PH, Verstraete FJM. 2012 Prevalence and types of tooth resorption in dogs with oral tumors. American Journal of Veterinary Research 73(7): 1057-1066

•    Arzi B, Willard VP, Huey DJ, Verstraete FJM, Vapniarsky-Arzi N, Athanasiou KA. 2012 The temporomandibular joint disc of Asian elephant (Elephas maximus) and African elephant (Loxodonta africana). European Journal of Wildlife Research 58(2): 451-459

•    Nemec A, Murphy B, Kass PH, Verstraete FJM. 2012 Histologic subtypes of oral nontonsillar squamous cell carcinoma in dogs. Journal of Comparative Pathology 147(4): 111-120

•    Nemec A, Zavodovskaya R, Affolter VK, Verstraete FJM. 2012 Erythema multiforme and epitheliotropic T-cell lymphoma in the oral cavity of dogs: 1989 - 2009. Journal of Small Animal Practice 53(8): 445-452

•    Nemec A, Verstraete FJM, Jerin A, Sentjurc M, Kass PH, Petelin M, Pavlica Z. 2012 Sistemska raven dušikovega oksida pri psih s parodontalno boleznijo [Systemic nitric oxide levels in dogs with periodontal disease]. Zobozdravstveni Vestnik [Slovenian Dental Journal] 67(1-2): 4-10

•    Fulton A, Fiani N, Arzi B, Lommer MJ, Kuntsi-Vaattovaara H, Verstraete FJM. 2012 Outcome of surgical endodontic treatment in dogs: 15 cases (1995-2011). Journal of the American Veterinary Medical Association 241(12): 1633-1638

2013

•    Arzi B, Cissell DD, Verstraete FJM, Kass PH, DuRaine GD, Athanasiou KA. 2013 Computed tomographic findings in temporomandibular joint disorders in 41 dogs and 17 cats: (2006-2011). Journal of the American Veterinary Medical Association 242(1): 69-75

•    Nemec A, Verstraete FJM, Jerin A, Šentjurc M, Kass PH, Petelin M, Pavlica Z. 2013 Periodontal disease, periodontal treatment and systemic nitric oxide in dogs. Research in Veterinary Science 94(3): 542-544

•    Winer JN, Liong SM, Verstraete FJM. 2013 The dental pathology of southern sea otters (Enhydra lutris nereis). Journal of Comparative Pathology 149(2-3): 346-355

•    Fulton A, Nemec A, Murphy BG, Kass PH, Verstraete FJM. 2013 Risk factors associated with survival in dogs with nontonsillar oral squamous cell carcinoma: 31 cases (1990-2011). Journal of the American Veterinary Medical Association 243(5): 696-702

•    Arzi B, Winer JN, Kass PH, Verstraete FJM. 2013 Osteoarthritis of the temporomandibular joint in southern sea otters (Enhydra lutris nereis). Journal of Comparative Pathology 149(4): 486-494

•    Tannenbaum J, Arzi B, Reiter AM, Peralta S, Snyder CJ, Lommer MJ, Harvey CE, Soukup JW, Verstraete FJ. 2013 The case against the use of dental implants in dogs and cats. Journal of the American Veterinary Medical Association 243(12): 1680-1685

2014

•    Farcas N, Arzi B, Verstraete FJM. 2014 Oral and maxillofacial osteosarcoma in dogs: a review. Veterinary and Comparative Oncology 12(3): 169-180

•    Fulton A, Arzi B, Murphy B, Naydan DK, Verstraete FJM. 2014 The expression of calretinin and cytokeratins in canine acanthomatous ameloblastoma and oral squamous cell carcinoma. Veterinary and Comparative Oncology 12(4): 258-265

•    Farcas N, Lommer MJ, Kass PH, Verstraete FJM. 2014 Dental radiographic findings in cats with chronic gingivostomatitis (2002-2012). Journal of the American Veterinary Medical Association 244(3): 339-345

•    Luotonen N, Kuntsi-Vaattovaara H, Sarkiala-Kessel E, Junnila JJ, Laitinen-Vapaavuori O, Verstraete FJM. 2014 Vital pulp therapy in dogs: 190 cases (2001-2011). Journal of the American Veterinary Medical Association 244(4):449-459

•    Henry T, Pusterla N, Guedes AG, Verstraete FJM. 2014 Evaluation and clinical use of an intraoral inferior alveolar nerve block in the horse. Equine Veterinary Journal 46(6): 706-710

•    Nemec A, Murphy BG, Jordan RC, Kass PH, Verstraete FJM. 2014 Oral papillary squamous cell carcinoma in twelve dogs. Journal of Comparative Pathology 150(2-3): 155-161

•    Fulton AJ, Fiani N, Verstraete FJM. 2014 Canine pediatric dentistry. Veterinary Clinics of North America Small Animal Practice 44(2): 303-324

•    Sinai NL, Dadaian RH, Kass PH, Verstraete FJM. 2014 Dental pathology of the California sea lion (Zalophus californianus). Journal of Comparative Pathology 151(1): 113-121

•    Meertens NM, Verstraete FJM, Van Garderen E, Vos JH, Peperkamp KHMT, Junker K, Dijkman JK. 2014 Ruimte-innemende processen in mondholte bij hond en kat. Deel 1: Differentiatie van ruimte-innemende processen in de mondholte bij hond en kat [Space-occupying lesions in the oral cavity in the dog and cat. Part 1 - Differential diagnosis of space-occupying lesions in the oral cavity in the dog and cat]. Tijdschrift voor Diergeneeskunde 139(11): 26-31

•    Meertens NM, Verstraete FJM, Van Garderen E, Vos JH, Peperkamp KHMT, Junker K, Dijkman JK. 2014 Ruimte-innemende processen in mondholte bij hond en kat. Deel 2: Meest voorkomende maligne tumoren bij de hond en bij de kat [Space-occupying lesions in the oral cavity in the dog and cat. Part 2 - Most common malignant tumors in the dog and cat]. Tijdschrift voor Diergeneeskunde 139(12): 22-28

2015

•    Meertens NM, Verstraete FJM, Van Garderen E, Vos JH, Peperkamp KHMT, Junker K, Dijkman JK. 2015 Ruimte-innemende processen in mondholte bij hond en kat. Deel 3: Meest voorkomende goedaardige tumoren en ‘tumor-like lesions’[Space-occupying lesions in the oral cavity in the dog and cat. Part 3 - Most common benign tumors and tumor-like lesions]. Tijdschrift voor Diergeneeskunde 140(1): 28-32

•    Arzi B, Verstraete FJ, Huey DJ, Cissell DD, Athanasiou KA. 2015 Regenerating mandibular bone using rhBMP-2: part 1 - immediate reconstruction of segmental mandibulectomies. Veterinary Surgery 44(4): 403-409
                
•    Verstraete FJ, Arzi B, Huey DJ, Cissell DD, Athanasiou KA. 2015 Regenerating mandibular bone using rhBMP-2: part 2 - treatment of chronic, defect non-union fractures. Veterinary Surgery 44(4): 410-416

•    Nemec A, Daniaux L, Johnson E, Peralta S, Verstraete FJM. 2015 Craniomaxillofacial abnormalities in dogs with congenital palatal defects: computed tomographic findings. Veterinary Surgery 44(4): 417-422

•    Peralta S, Nemec A, Fiani N, Verstraete FJM. 2015 Staged double-layer closure of palatal defects in dogs: 6 cases (2006-2012). Veterinary Surgery 44(4): 423-431

•    Arzi B, Verstraete FJ. 2015 Internal fixation of severe maxillofacial fractures in dogs. Veterinary Surgery  44(4): 437-442

•    Arzi B, Murphy MK, Leale DM, Vapniarsky-Arzi N, Verstraete FJM. 2015 The temporomandibular joint of California sea lions (Zalophus californianus): Part 1 – Characterisation in health and disease. Archives of Oral Biology 60(1): 208-215

•    Arzi B, Leale DM, Sinai NL, Kass PH, Lin A, Verstraete FJM. 2015 The temporomandibular joint of California sea lions (Zalophus californianus): Part 2 – osteoarthritic changes. Archives of Oral Biology 60(1): 216-222

•    Arzi B, Kol A, Murphy B, Walker NJ, Wood J, Clark KC, Verstraete FJM, Borjesson DL. 2015 Feline foamy virus adversely affects feline mesenchymal stem cell culture and expansion: implications for animal model development. Stem Cells Development 24(7): 814-823

•    McDonald M, Vapniarsky-Arzi N, Verstraete FJM, Staszyk C, Leale DM, Woolard KD, Arzi B. 2015 Characterization of the temporomandibular joint of the harbour porpoise (Phocoena phocoena) and Risso's dolphin (Grampus griseus). Archives of Oral Biology 60(4): 582-592

•    Aalderink MT, Nguyen HP, Kass PH, Arzi B, Verstraete FJM. 2015 Dental and temporomandibular joint pathology of the northern fur seal (Callorhinus ursinus). Journal of Comparative Pathology 152(4): 325-334

•    Aalderink MT, Nguyen HP, Kass PH, Arzi B, Verstraete FJM. 2015 Dental and temporomandibular joint pathology of the Eastern Pacific harbour seal (Phoca vitulina richardii). Journal of Comparative Pathology 152(4): 335-344

•    Arzi B, Cissell DD, Pollard RE, Verstraete FJM. 2015 Regenerative approach to bilateral rostral mandibular reconstruction in a case series of dogs. Frontiers in Veterinary Science 30;2:4. doi: 10.3389/fvets.2015.00004.

•    Nemec A, Arzi B, Hansen K, Murphy BG, Lommer MJ, Peralta S, Verstraete FJM. 2015 Osteonecrosis of the jaws in dogs in previously irradiated fields: 13 cases (1989-2014). Frontiers in Veterinary Science 1;2:5. doi: 10.3389/fvets.2015.00005.

•    Peralta S, Arzi B, Nemec A, Lommer MJ, Verstraete FJM. 2015 Non-radiation-related osteonecrosis of the jaws in dogs: 14 cases (1996-2014). Frontiers in Veterinary Science 5;2:7. doi: 10.3389/fvets.2015.00007.

•    Lieske D, Vapniarsky N, Verstraete FJM, Leale DM, Young C, Arzi B. 2015 Characterization of the temporomandibular joint of southern sea otters (Enhydra lutris nereis). Frontiers in Veterinary Science 9;2:71. doi: 10.3389/fvets.2015.00071.

•    Kol A, Arzi B, Athanasiou KA, Farmer DL, Nolta JA, Rebhun RB, Chen X, Griffiths LG, Verstraete FJM, Murphy CJ, Borjesson DL. 2015 Companion animals: translational scientist's new best friends. Science Translational Medicine 7:7(308):308ps21. doi: 10.1126/scitranslmed.aaa9116.

2016

•    Arzi B, Mills-Ko E, Verstraete FJM, Kol A, Walker NJ, Badgley MR, Fazel N, Murphy WJ, Vapniarsky N, Borjesson DL. 2016 Therapeutic efficacy of fresh, autologous mesenchymal stem cells for severe refractory gingivostomatitis in cats. Stem Cells Translational Medicine 5(1):75-86

•    Aghashani A, Kim AS, Kass PH, Verstraete FJM. 2016 Dental pathology of the California bobcat (Lynx rufus californicus). Journal of Comparative Pathology 154(4):329-340

•    Arzi B, Stover SM, Garcia TC, Leale DM, Verstraete FJM. 2016 Biomechanical evaluation of two plating configurations for critical-sized defects of the mandible in dogs. American Journal of Veterinary Research. 77(5):445-451

•    Fiani N, Verstraete FJM, Arzi B. 2016 Reconstruction of congenital nose, cleft primary palate, and lip disorders. Veterinary Clinics of North America Small Animal Practice 46(4):663-675

•    Strøm PC, Arzi B, Cissell DD, Verstraete FJM. 2016 Ankylosis and pseudoankylosis of the temporomandibular joint in 10 dogs (1993-2015). Veterinary and Comparative Orthopaedics and Traumatology 29(5). [Epub ahead of print]

•    Winer JN, Arzi B, Verstraete FJM. 2016 Therapeutic management of feline chronic gingivostomatitis: a systematic review of the literature. Frontiers in Veterinary Science. 2016 Jul 18;3:54. doi: 10.3389/fvets.2016.00054.

•    Winer JN, Arzi B, Leale DM, Kass PH, Verstraete FJM. 2016 Dental and temporomandibular joint pathology of the polar bear (Ursus maritimus). Journal of Comparative Pathology doi:10.1016/j.jcpa.2016.07.004. [Epub ahead of print]

•    Winer JN, Arzi B, Leale DM, Kass PH, Verstraete FJM. 2016 Dental and temporomandibular joint pathology of the walrus (Odobenus rosmarus). Journal of  Comparative Pathology doi: 10.1016/j.jcpa.2016.07.005. [Epub ahead of print]