William R. Pritchard Veterinary Medical Teaching Hospital

Clinical Studies and Outcomes

The research program in Dentistry & Oral Surgery focuses on clinical research in veterinary dentistry in order to improve our understanding of oral disease processes, to expand upon available treatment options, and to optimize patient care. Investigational procedures are rarely performed on patients; rather, the utilization of patient material for clinical research is optimized by keeping comprehensive records, collecting specimens and samples, and ensuring adequate follow-up.

Current studies include the following:
  • Comparative oral pathology, including genotypic and phenotypic cellular differences in tumors from the oral cavities of different species
  • Dental radiology in the dog and cat
  • Diagnostic imaging of maxillofacial trauma in dogs and cats
  • Clinical dentistry in rabbits and rodents, particularly the management of malocclusion
  • Resorption lesions and chronic stomatitis in cats, including investigation of possible causes and treatments
  • Reconstruction following maxillofacial surgery
Recent publications based on research:
  • Kuntsi-Vaattovaara H., Verstraete F.J.M., Kass P.H. 2002 Success rate of root canal treatment in dogs: 127 cases (1995-2000). Journal of the American Veterinary Medical Association 220: 775-780
  • Colley P.A., Verstraete F.J.M., Kass P.H., Schiffman P. 2002 Elemental composition of normal feline teeth and feline teeth with odontoclastic resorption lesions. American Journal of Veterinary Research 63: 546-550
  • Verstraete F.J.M. 2003 Advances in diagnosis and treatment of small exotic mammal dental disease. Seminars in Avian and Exotic Pet Medicine 12(1): 37-48
  • Lommer M.J., Verstraete F.J.M. 2003 Concurrent oral shedding of feline calicivirus and feline herpesvirus-1 in cats with chronic gingivostomatitis. Oral Microbiology and Immunology 18(2): 131-134
  • Tsugawa A.J., Verstraete F.J.M., Kass P.H., Gorrel C. 2003 Diagnostic value of the lateral and occlusal radiographic views vs. periodontal probing in the assessment of periodontal attachment of the canine teeth in dogs. American Journal of Veterinary Research 64(3): 255-261
  • Kuntsi-Vaattovaara H., Verstraete F.J.M., Newsome J.T., Yuan H. 2003 Resolution of persistent oral papillomatosis in a dog after treatment with a recombinant canine oral papilloma virus vaccine. Veterinary and Comparative Oncology 1(1): 57-63
  • Verstraete F.J.M. 2005 Mandibulectomy and maxillectomy. Veterinary Clinics of North America - Small Animal Practice 35: 1009-1039
  • Verstraete F.J.M., Osofsky A. 2005 Dentistry in pet rabbits. Compendium on Continuing Education for the Practicing Veterinarian 27: 671-684
  • Brenner S.Z.G. , Hawkins M.G., Tell L.A., Hornof W.J., Plopper C.G., Verstraete F.J.M. 2005 Clinical anatomy, radiography and computed tomography of the skull of the chinchilla (Chinchilla lanigera). Compendium on Continuing Education for the Practicing Veterinarian 27: 933-944
  • Osofsky A., Verstraete F.J.M. 2006 Dentistry in pet rodents. Compendium on Continuing Education for the Practicing Veterinarian 28: 61-74
  • Lurie D.M., Seguin B., Schneider P.D., Verstraete F.J.M., Wisner E.R. 2006 Contrast-assisted ultrasound for sentinel lymph node detection in spontaneously arising canine head and neck tumors. Investigative Radiology 41: 415-421
  • Bar-Am Y., Pollard R.E., Kass P.H., Verstraete F.J.M. 2008 The diagnostic yield of conventional radiographs and computed tomography in dogs and cats with maxillofacial trauma. Veterinary Surgery 37: 294-299
  • Arzi B., Anderson J.G., Verstraete F.J.M. 2008 Oral manifestations of systemic disorders in dogs and cats. Journal of Veterinary Clinical Sciences 1(4): 4-16
  • Resler J., Verstraete F.J.M. 2009 Maintaining oral health in our companion animals. The treatment of periodontal diseases in dogs and cats. Dimensions of Oral Hygiene 7(11): 50-53
  • Arzi B., Murphy B., Cox D.P., Vapniarsky N., Kass, P.H., Verstraete F.J.M. 2010 Presence and quantification of mast cells in the gingiva of cats with tooth resorption, periodontitis and chronic stomatitis. Archives of Oral Biology 55(2): 148-154
  • Arzi B., Verstraete F.J.M. 2010 Mandibular rim excision in 7 dogs. Veterinary Surgery 39(2): 226-231
  • Bar-Am Y., Verstraete F.J.M. 2010 Elastic training for the prevention of mandibular drift following mandibulectomy in dogs: 18 cases (2005-2008). Veterinary Surgery 39(5): 784-793
  • Peralta S., Verstraete F.J.M., Kass P.H. 2010 Radiographic evaluation of the types of tooth resorption in dogs. American Journal of Veterinary Research 71(7): 784-793
  • Peralta S., Verstraete F.J.M., Kass P.H. 2010 Radiographic evaluation of the classification of the extent of tooth resorption in dogs. American Journal of Veterinary Research 71(7): 794-798
  • Nemec A., Pavlica Z., Petelin M., Crossley D.A., Šentjurc M., Jerin A., Eržen D., Zdovc I., Hitti T., Skalerič U. 2010 Systemic use of selective iNOS inhibitor 1400W or non-selective NOS inhibitor L-NAME differently affects systemic nitric oxide formation after oral Porphyromonas gingivalis inoculation in mice. Archives of Oral Biology 55: 509-514
  • Arzi B., Murphy B., Baumgarth N., Vapniarsky N., Nemec A., Naydan D., Cox D.P., Verstraete F.J.M. 2011 Analysis of immune cells within the healthy oral mucosa of specific pathogen free cats. Anatomia, Histologia, Embryologia 40: 1-10
  • Fiani N., Verstraete F.J.M., Kass P.H., Cox D.P. 2011 Clinicopathologic characterization of odontogenic tumors and focal fibrous hyperplasia in dogs: 152 cases (1995–2005). Journal of the American Veterinary Medical Association 238(4): 495-500
  • Fiani N., Arzi B., Johnson E.G., Murphy B., Verstraete F.J.M. 2011 Osteoma of the oral and maxillofacial regions in cats: 7 cases (1999-2009). Journal of the American Veterinary Medical Association 238(11): 1470-1475
  • Nemec A., Jerin A., Zdovc I., Budefeld T., Verstraete F.J.M., Eržen D., Šentjurc M., Petelin M., Hitti T., Pavlica Z. 2011 Early systemic inflammatory response in mice after a single oral gavage with live Escherichia coli is evidenced by increased TNF-alpha and nitric oxide production. Research in Veterinary Science doi:10.1016/j.rvsc.2011.03.021
  • Arzi B., Murphy B., Nemec A., Vapniarsky N., Naydan D.K., Verstraete F.J.M. 2011 Expression of cytokeratins in the epithelium of canine odontogenic tumours. Journal of Comparative Pathology 145: 345-351
  • Arzi B., Verstraete FJ. 2011 Repair of a bifid nose combined with a cleft of the primary palate in 1-year-old dog. Veterinary Surgery: 865-869.
  • Arzi B, Willard VP, Huey DJ, Verstraete FJ, Vapniarsky N, Athanasiou KA. The temporomandibular joint disc of Asian elephant (Elephas maximus) and African elephant (Loxodonta africana). European Journal of Wildlife research. 2011; DOI: 10.1007/s10344-011-0595-x.
  • Willard VP, Arzi B, Athanasiou KA. The attachments of the temporomandibular joint disc: A biochemical and histological investigation. Arch Oral Biol 2011; DOI:10.1016/j.archoralbio.2011.10.004.
  • Nemec A., Pavlica Z., Nemec-Svete A., Eržen D., Milutinović A., Petelin M. Aerosolized clindamycin is superior to aerosolized dexamethasone or clindamycin-dexamethasone combination in the treatment of severe Porphyromonas gingivalis aspiration pneumonia in an experimental murine model. Experimental Lung Research (Accepted 2011)
  • Nemec A., Arzi B., Murphy B., Kass P.H., Verstraete F.J.M. The occurrence and types of tooth resorption in dogs with oral tumors. American Journal of Veterinary Research (Accepted 2011)
  • Fulton A., Fiani N., Arzi B., Lommer M., Kuntzi H., Verstraete F.J.M. Outcome of surgical endodontic treatment in dogs: 15 cases (1995-2011). Journal of the American Veterinary Medical Association (Accepted 2011)
  • Nemec A., Murphy B., Kass P.H., Verstraete F.J.M. Histological subtypes of oral non-tonsillar squamous cell carcinoma in dogs. Journal of Comparative Pathology (Accepted 2011)