J.D. Wheat Veterinary Orthopedic Research Laboratory


Cell and Molecular Biology:

Yellowley, C.E. (1995) Electrophysiological characterisation of human osteoblast-like cells: Ph.D. dissertation, Bristol University, U.K.

Yellowley, C.E., Jacobs, C.R., Zhou, Z., Li, Z. and Donahue, H.J. (1997) Effects of fluid flow on intracellular calcium in bovine articular chondrocytes. Am. J. Physiol. 273:42 ppC30-C36.

Lee, Y-C., Yellowley, C.E., Li, Z., Donahue, H.J. and Rannels, D.E. (1997) Expression of functional gap junctions in cultured alveolar cells. Am. J. Physiol. 272:16 pp L1105-L1114.

Donahue, H.J., Vander Molen, M.A., Yellowley, C.E., and Li, Z. (1997) Gap junctional communication in bone. Cells and Materials 6(1-3) 10-20.

Yellowley, C.E., Hancox, J.C., Skerry, T.M. and Levi, A.J. (1998) Whole cell membrane currents from human osteoblast-like cells. Calcified Tissue International 62:122-132.

Jacobs, C.R., Yellowley, C.E., Davis, B.R, Zhou, Z. and Donahue, H.J. (1998) Differential effect of steady versus oscillating flow on bone cells. Journal of Biomechanics. 31; 969-976 Winner of the 1998 Research Award of the European Society of Biomechanics

Yellowley, C.E., Jacobs, C.R and Donahue, H.J. (1999) Mechanisms contributing to fluid-flow-induced Ca2+ mobilization in articular chondrocytes. Journal of Cellular Physiology 180:402-408.

Li, Z., Zhou, Z., Yellowley, C.E. and Donahue, H.J. (1999) Inhibiting gap junctional intercellular communication alters expression of differentiation markers in osteoblastic cells. Bone 25 (6) 661-666.

Donahue, H.J., Li, Z., Zhou, Z. and Yellowley, C.E (2000) Differentiation of human fetal osteoblast cells and gap junctional intercellular communication. American Journal of Physiology, Cell Physiology,.Feb, 278 (2), C315-322.

Yellowley, C.E., Jacobs, C.R., Zhou, Z., Li, Z. and Donahue, H.J. (2000) Functional gap junctions between osteocytic and osteoblastic cells. Journal of Bone and Mineral Research 15 (2) 209-217.

You, J., Yellowley, C.E., Donahue, H.J., Zhang, Y., Chen, Q. and Jacobs, C.R. (2000) Substrate deformation levels associated with routine physical activity are less stimulatory to bone cells relative to loading-induced oscillatory fluid flow. Journal of Biomechanical Engineering. August Volume122, Issue 4 pp. 387-393.

Jacobs, C.R., Yellowley, C.E., Nelson, D.V. and Donahue, H.J. (2000) Analysis of Time varying biological data using rainflow cycle counting. Computer Methods in Biomechanics and Biomedical Engineering. Vol. 3, pages 31-40.

Edlich M, Yellowley, C.E., Jacobs, C.R and Donahue, H.J. (2001) Oscillating fluid flow regulates cytosolic calcium concentration in bovine articular chondrocytes. Journal of Biomechanics Vol. 34 p 59-65.

Guo, Y., Martinez-Williams, C., Yellowley, C.E., Donahue, H.J. and Rannels, D.E. (2001) Connexin expression by alveolar epithelial cells is regulated by extracellular matrix. American Journal of Physiology: Lung Cell and Molecular Physiology 280: L191-L202.

You, J., Reilly, G.R., Zhen, X., Yellowley, C.E., Chen, Q., Donahue, H.J., and Jacobs, C.R. (2001) Osteopontin gene regulation by oscillatory fluid flow via intracellular calcium mobilization and activation of mitogen-activated protein kinase in MC3T3-E1 osteoblasts. Journal of Biological Chemistry 276: 13365-13371.

Sharma, R., Yellowley, C.E., Civelek, M., Ainslie, K., Hodgson, L., Tarbell, J. M. and Donahue, H.J. (2002) Intracellular calcium changes in rat aortic smooth muscle cells in response to fluid flow. Annals of Biomedical Engineering Mar;30(3):371-8.

Yellowley, C.E., Hancox, J.C. and Donahue, H.J. (2002) Effects of cell swelling on intracellular calcium and membrane currents in bovine articular chondrocytes. J Cell Biochem. 86(2):290-301.

Saunders, M.M., You, J., Zhou, Z., Li, Z., Yellowley, C.E., Kunze, E., Jacobs, C.R. and Donahue, H.J. (2003) Fluid flow-induced Prostaglandin E2 response of osteoblastic ROS 17/2.8 cells is gap junction-mediated and independent of cytosolic calcium. Bone Apr;32(4):350-6.

Haut Donahue, T.L., Haut, T.R., Yellowley, C.E., Donahue, H.J. and Jacobs, C.R. (2003). Mechanosensitivity of bone cells to oscillating fluid flow induced shear stress may be modulated be chemotransport. Journal of Biomechanics 36 (9) 1363-1371.

Reilly, G.R., Haut, T.R., Yellowley, C.E., Donahue, H.J. and Jacobs, C.R. (2003) Fluid flow induced PGE2 release by bone cells is reduced by glycocalyx degradation whereas calcium signals are not. Biorheology; Volume 40, No.6 p591-603.

Alford, A.I., Yellowley, C.E., Jacobs, C.R., and Donahue, H.J. (2003) Increases in cytosolic calcium, but not fluid flow, affect aggrecan mRNA levels in articular chondrocytes. Journal of Cellular Biochemistry 90: 938-944.

Haut Donahue, TL., Donahue, H.J., Jacobs, C.R. and Yellowley, C.E. (2004). Annexin V disruption impairs mechanically-induced calcium signaling in osteoblast cells. Bone 35: 656-663.

Li, Y., Batra, N.N., You, L., Meier, S.C., Yellowley, C.E., Jacobs, C.R. (2004) Oscillatory fluid flow affects human marrow stromal cell proliferation and differentiation. Journal of Orthopedic Research Nov; 22(6):1283-9.

Edlich, M., Yellowley, C.E., Jacobs, C.R. and Donahue, H.J. (2004) Cycle number and waveform of fluid flow affect bovine articular chondrocytes. Biorheology 41 (3-4) 315-322.

Batra, NN., Li, Y., Yellowley, C.E., You, L., Malone, AM., Kim, CH. and Jacobs, C.R. (2005) Effects of short-term recovery periods on fluid-induced signaling in osteoblastic cells. J. Biomech. Sep;38(9):1909-17.

Kim, C., Yellowley, C.E. and Jacobs, C.R. (2006) Oscillatory fluid flow induced shear stress decreases osteoclastogenic activity through regulation of RANKL and OPG. Bone. Nov; 39(5):1043-1047.

Lee, C.M., Genetos, D.C., You. Z. and Yellowley, C.E. (2007). Hypoxia regulates PGE2 release and EP-1 receptor expression in osteoblastic cells. Journal of Cellular Physiology. Jul;212(1):182-8.

Genetos, D.C., Kephart, C.J., Zhang, Y., Yellowley, C.E. and Donahue, H.J. (2007) Oscillatory fluid flow activation of gap junction hemichannels promotes ATP release in MLO-Y4 osteocytes. Journal of Cellular Physiology. July;212(1):207-14

Waters, K.M, Tan, R., Genetos, D.C., Verma, S., Yellowley, C.E. and Karin, N.J. (2007) DNA microarray analysis reveals a role for lysophosphatidic acid in the regulation of anti-inflammatory genes in MC3T3-E1 cells. Bone. 2007 Nov;41(5):833-41

Russell, J.M., Stephenson, G.S., Yellowley, C.E. and Benton, H.P. (2007) Adenosine inhibition of lipopolysaccharide-induced interleukin 6 secretion by the osteoblastic cell line, MG-63. Calcified Tissue International. 2007 Oct;81(4):316-26

Raheja, L.F., Genetos, D.C. and Yellowley, C.E. (2008) Hypoxic osteocytes recruit human MSCs through an OPN/CD44-mediated pathway. Biochemical and Biophysical Research Communications Feb 22;366(4):1061-6.