J.D. Wheat Veterinary Orthopedic Research Laboratory

The skeleton and hypoxia

Oxygen tension in the environment surrounding bone cells can vary under certain circumstances. For example, skeletal unloading has been shown to induce osteocyte hypoxia. In addition, bone cells in the vicinity of a fracture experience a significant decrease in oxygen tension due to disruption of the vasculature. We are pursuing this line of study by investigating the effects of oxygen on bone cell differentiation, physiology and ultimately bone turnover. 

Photo: The Skeleton and Hypoxia schematic

Photo: The Skeleton and Hypoxia image

Publications

Lee, C.M., Genetos, D.C., You. Z. and Yellowley, C.E. (2007). Hypoxia regulates PGE2 release and EP-1 receptor expression in osteoblastic cells. Journal of Cellular Physiology. Jul;212(1):182-8.

Raheja, L.F., Genetos, D.C. and Yellowley, C.E. (2008) Hypoxic osteocytes recruit human MSCs through an OPN/CD44-mediated pathway. Biochemical and Biophysical Research Communications Feb 22;366(4):1061-6.

Genetos, D.C., Lee, C.M., Wong, A. and Yellowley, C.E. (2009). HIF-1 alpha regulates hypoxia-induced EP1 expression in osteoblastic cells. J Cell Biochem. 2009 Mar 10;107(2):233-239.

Lee, C.M., Genetos, D.C., Wong, A. and Yellowley, C.E. (2009) Prostaglandin expression profile in hypoxic osteoblastic cells. In Press Journal of Bone and Mineral Metabolism.

Raheja, L.F., Genetos, D.C. and Yellowley, C.E. (2009). The effect of oxygen tension on the long-term osteogenic differentiation and MMP/TIMP expression of human mesenchymal stem cells. In Press Cells Tissue and Organs.