J.D. Wheat Veterinary Orthopedic Research Laboratory

Photo: PhD candidate Mandy Murray, DVM, MPVM, uses a microscope to asses histology of bone in the study of Silicate Associated Osteoporosis
PhD candidate Mandy Murray, DVM, MPVM, uses a microscope to asses histology of bone in the study of Silicate Associated Osteoporosis.

Silicosis Associated Osteoporosis

Silicate Associated Osteoporosis

We are investigating a recently identified disease in horses in which the bones become weak and osteoporotic. Research is focused on 1) determining what happens to the bones on microscopic level and 2) identifying the underlying mechanism of the disease. The ultimate goal of the research is to find optimal management of the affected horses and prevention strategies. Because many of the horses with the bone disease also have a lung disease called pulmonary silicosis, we are pursuing understanding of the link between the lung disease and the bone disease. 

Dr. Mandy (Murray) Arens has greatly advanced our understanding of SAO through her remarkable work and has completed her PhD in 2011. Dr. Regina Zavodovskaya, with interest is bone pathology, presently continues the investigation of SAO.

Photo: Silicate Associated Osteoporosis image

 
Figure. Note the prominent shoulder blades (arrow) and sway back characteristic of horse with silicate associated osteoporosis

Publications

Anderson J, Galuppo, L., Barr, B., Puchalski, S., MacDonald, M., Magdesian,G, Stover, SM.: Scintigraphic findings and clinical characterization of a bone fragility disorder in horses: 16 cases (1980-2006). Journal of American Veterinary Medical Association 232: 1694-1699, 2008

Durham M, Armstrong, CM: Fractures and Bone Deformities in 18 horses with Silicosis. Proceedings of the 52nd Annual Convention of the American Association of Equine Practitioners, San Antonio, Texas, USA, 2-6 December, 2006. 311-317

Contacts

Regina Zavodovskaya, MS, DVM, Dipl ACVP
Postdoctoral researcher
rzav@ucdavis.edu

Susan M. Stover, DVM, PhD, Dipl ACVS
Professor
smstover@ucdavis.edu