J.D. Wheat Veterinary Orthopedic Research Laboratory

Faculty

Photo: Sue Stover

Susan M. Stover, DVM, PhD, Dipl ACVS

Dr. Stover's research focuses on the diagnosis, treatment, and prevention of musculoskeletal injuries, predominantly in horses, but also in small animals.  She specialized in equine surgery and lameness until devoting full time to research on musculoskeletal biomechanics and on the causes, development, and prevention of musculoskeletal injuries in equine athletes.  Current research focuses include 1) the effects of race surface and horseshoes on limb biomechanics (and thus risk for injury) and 2) investigating a systemic bone fragility syndrome that causes pathologic fractures in horses.

Photo: Clare Yellowley

Clare Yellowley, PhD

Dr. Yellowley's research goals are to understand the nature of bone and cartilage cells to their microenvironment.  Her laboratory has developed systems for applying mechanical load to bone and cartilage cells in vitro, allowing for study of the effects of load on cell biology, for example, differentiation, cellular signaling, metabolism and gene expression.   Another area of interest is the effect of oxygen as a critical regulator of bone cells is the oxygen availability, which is changes due to bone unloading and at a fracture site due to disruption of the vasculature.

Photo: Damian Genetos

Damian C. Genetos, PhD

Dr. Genetos’s research focuses upon the mechanisms whereby bone cells respond to biophysical signals present during skeletal development, repair, and daily activity.  Using both in vitro models for mechanical loading and in vivo transgenic or knockout mouse models, current research focuses include 1) the interaction of mechanical and chemical signals upon skeletal homeostasis;  2) diseases involving the skeletal system, including ectopic calcification within the vasculature, or mechanisms of prostate cancer osteosclerosis.

Photo: Amy Kapatkin

Amy Kapatkin, DVM, MS, Dipl ACVS

Dr. Kapatkin's expertise is small animal orthopedic surgery.  Her research interests are in kinetics (the force of motion) and kinematics (the motion of joints), which give an objective measure of how a patient is progressing after treatment or surgery and evidence-based medicine.

Martin Vidal

Martin Vidal, BVSc, MS, PhD, Dipl ACVS

Dr. Vidal's expertise is in equine surgery, with an emphasis on lameness evaluation and orthopedic diseases. His primary research interests are in equine orthopedic diseases with a focus on the biology and application of equine somatic stem cells for regenerative tissue repair. As a member of the Stem Cell Regenerative Medicine Group, Dr. Vidal’s laboratory is currently studying specific biological properties of equine stem cells from different tissue sources related to growth and differentiation, senescence, and responses to growth factors. Long-term research objectives are to shed light on the interactions between stem cells and natural tissue and to optimize regenerative medicine approaches for tissue repair in tendons and ligaments.

Photo: Sarah Puchalski

Sarah Puchalski, DVM

Dr. Puchalski's expertise is in diagnostic imaging, focusing in equine orthopedics.  Her interests include cross-sectional imaging of the equine distal limb, and imaging of musculoskeletal disease.

Photo: Larry D. Galuppo

Larry D. Galuppo, DVM, Dipl ACVS

Dr. Galuppo's clinical expertise in equine orthopedic surgery including tendon and ligament injuries, joint disease, with special interest in traumatology and fracture repair. His research emphasis is on biomechanics of fracture generation, implant design and fracture repair, with focus in novel healing methods for musculoskeletal injuries utilizing regenerative medicine technology.

Photo: Blaine Christiansen

Blaine Christiansen, PhD

Dr. Christiansen's research explores the role of the mechanical environment in determining the structure and strength of bone. His interests include investigating bone adaptation to various methods of increased and decreased mechanical loading, as well as the use of cutting-edge imaging methods for quantifying bone morphology and adaptation.

Photo: David Fyhrie

David Fyhrie, PhD

Dr. Fyhrie's research interests include bone biomechanics, bone remodeling, cartilage mechanical properties, bone cell mechanobiology, bone remodeling, fracture mechanics, and finite element modeling.

Photo: Boaz Arzi

Boaz Arzi, DVM, Dipl AVDC, Dipl EVDC

Dr. Arzi's current research fields are 1) regenerating the mandibular bone after resective surgery or due to defect non-unions. This project combines the use of BMP-2 and a scaffold and efforts towards understanding stem-cells recruitments locally and systemically 2) adipose-derived mesanchymal stem cells for the treatment of feline gingivostomatitis. 3) the biomechanics of mandibular reconstruction as dependent on the fixation method. 4) Temporomandibular joint (TMJ) disorders among the mammalian species. These projects extend and bridge the clinical practice at the UC Davis VMTH on one side and basic and regenerative laboratory science on the other side. Dr. Arzi also has collaborative research work with Dr. Athanasiou's biomedical engineering lab in the field of articular and fibrocartilage regeneration.