We conduct research on the clinical pharmacology of anesthetic and analgesic agents in various small animal species, particularly cats, rabbits and birds. The laboratory is well equipped for pharmacokinetic-pharmacodynamic studies of nociception and inflammatory pain, as well as for measuring the cardiorespiratory effects of drugs, in conscious or anesthetized animals.
Center for Imaging Sciences
The Center for Imaging Science (CIS) provides a central facility containing state-of-the-art imaging equipment and core faculty with expertise in medical imaging investigations. The CIS occupies approximately 3,000 sq. ft. in the Vet Med II building on the UC Davis campus. Because the CIS is housed within and is integrated with the William R. Pritchard Veterinary Medical Teaching Hospital in the UC Davis School of Veterinary Medicine, in addition to defined imaging research space, CIS has immediate access to supply, pharmacy and other ancillary resources within the hospital. The facility also contains institutionally approved housing for both large and small animal research subjects. The services that the CIS currently provide include diagnostic radiology, x-ray computed tomography, magnetic resonance imaging, diagnostic ultrasound, radiation therapy, interventional radiology and image analysis for in vitro and animal research. Current research includes, but is not limited to, development and testing of novel contrast media, evaluation of new diagnostic imaging methods, development and testing of new imaging technologies, analyzing kinetics of new pharmaceuticals in animal models, development and testing of novel implantable devices, and monitoring the effects of new therapeutic approaches. The laboratory is self-supporting and funding is generated through a recharge mechanism for services rendered. The CIS has a shared use agreement with the Veterinary Medical Teaching Hospital and has a second recharge mechanism in place for use of the hospital’s imaging equipment, space and personnel.
Comparative Dentistry Laboratory
The Comparative Dentistry research program focuses on clinical research in veterinary dentistry and oral surgery in order to improve our understanding of oral disease processes, to expand upon available treatment options, and to optimize patient care. Current studies include comparative oral tumor pathology, advances in diagnostic imaging, including cone-beam computed tomography, and reconstruction following maxillofacial surgery. A second focus is on mesenchymal stem-cell therapy for cats with chronic gingivostomatitis. A third focus is on comparative dental and temporomandibular joint pathology in domestic and wild animals, in an effort to determine to what extent these lesions contribute to morbidity and mortality.
Comparative Gastroenterology Laboratory
The Comparative Gastroenterology Laboratory was founded by Dr. Jack Snyder over 20 years ago. The two primary investigators Dr. Jorge Nieto and Dr. Jack Snyder, both PhDs and ACVS diplomats had focus on advancing the knowledge for the prevention and treatment of horses with colic. The laboratory has made major advances in the knowledge of equine gastric ulcers, gastro-intestinal motility, treatment and prevention of ischemia reperfusion injury, and in developing tools for early diagnosis of strangulating lesion in horses with colic. Advances from our research have made possible to dramatically increase the survival rate of horses with colic. The laboratory has also made research in the sport medicine field and introduced the use of thermography to detect hypersensitivity in order to provide a competitive advantage, a technique that the FEI adopted in competitions in 2008. The laboratory has published over 150 publications in per review scientific journals.
Comparative Oncology Core Laboratory
The comparative oncology core laboratory serves as a resource for 8 independent Faculty investigators each with individual interests and expertise in clinical and laboratory based research including radiation oncology, novel therapeutics, cancer cell signaling, comparative and translational oncology, comparative molecular biology, tumor metastasis, and clinical trials in VMTH patients. The core laboratory is also integral to the collection, processing, handling, and storage of tissues for institutional and multi-institutional clinical trials including participation in The Comparative Oncology Trials Consortium (COTC); an active network of twenty academic comparative oncology centers, centrally managed by the NIH-NCI-Center for Cancer Research's Comparative Oncology Program.
Equine Athletic Performance Laboratory
The Claire Giannini Hoffman Equine Athletic Performance Laboratory (EAPL) is a facility designed to study equine and comparative exercise physiology, biomechanics and drug effects on performance, as well as to perform clinical evaluations of animals presented to the William R. Pritchard Veterinary Medical Teaching Hospital for poor performance. Two high-speed Kagra Mustang treadmills and associated metabolic, gas analysis, blood analysis and cardiopulmonary instrumentation enable scientists and veterinarians to measure numerous aspects of energetics, cardiovascular and respiratory function while animals, e.g., horses, exercise maximally. Ancillary clinical instrumentation, e.g., flexible fiberoptic videoendoscopes, electrocardiograms or cardiac ultrasound units are used to provide detailed examination of specific aspects of exercise function. High-speed video cameras and force plates are used to perform kinematic and biomechanical analyses of locomotion in horses and small animals. Collaborative studies with the Kenneth L. Maddy Equine Analytical Chemistry Laboratory examine effects of drugs on athletic performance as well as evaluating metabolism and excretion of them so that analytical protocols can be developed for sensitive and accurate detection of their use in drug-testing programs. Ancillary equipment to support the Laboratory's mission includes a motorized equine circular exerciser adjacent to the laboratory for maintaining exercise fitness of horses used in studies.
The mediaLab is a full service photography, video and graphic unit. We provide the department of Surgical and Radiological Sciences with a variety of graphic media for use in instruction, publication and research. These services include photography, video production, illustrations, 3D modeling and animations and multimedia production. In addition we provide digital scanning and both small and large format printing.
The Mellema Lab is focused on the identification and characterization of biological signals whose carriers are in the sub-micron range. Using State-of-the-Art methodologies such as fluorescent nanoparticle tracking analysis (fNTA) and flow cytometry, the lab investigates the role of exosomes and microparticles in the pathophysiology of diverse disease states such as leptospirosis, obstructive sleep apnea, endothelial dysfunction, bowel ischemia, cancer, hemolytic anemias, and oxygen toxicity. In addition, the lab also focuses on the role of nanoscale particulates in the formation of kidney and bladder stones in animals and humans. Mammalian cell culture-based modeling systems are used widely in these investigations.
The Clinical Neurophysiology and Neuromuscular Disease Laboratories were established in the 1970s by and Dr Terrell Holliday Dr George Cardinet in. They provide state of the art support for the diagnosis and investigation of neuromuscular and neurological diseases in clinical patients at the Veterinary Medical Teaching Hospital and support for comparative research for the UC Davis campus and beyond. Specialized testing provided through the laboratories includes electrophysiological assessment of peripheral nerve, muscle, and neuromuscular junctional disorders, auditory testing, and electroencephalograhy (EEG) for the assessment and classification of seizure disorders. The Neuromuscular disease laboratory evaluates muscle and nerve pathology through enzyme histochemical and immunohistochemical procedures and both laboratories provide instructional support for the training of DVM students, specialty residents and clinical practitioners at the generalist and specialty level.
Paul C. and Borghild T Peterson Brain Tumor Research Laboratory
The laboratory was established in 2000 with the goal of advancing the treatment of brain tumors through basic science and clinical translational research. The laboratory is integral to the development of novel therapies for brain tumors entering into clinical trials for patients in the Veterinary Medical Teaching Hospital and also provides training in clinical translational research for Neurology/Neurosurgery residents, DVM students and visiting researchers. The laboratory has strong links with other translational groups including the School of Medicine, Genetics, Bioinformatics and Clinical imaging.