Archived News

Lost in the Fog: Chemo Begins

Prepared by: Dr. W. David Wilson, Director of Large Animal Clinical Services

September 8, 2006

Lost in the FogEditor's note: The information below comes directly from the veterinarians in charge of Lost in the Fog's care during his chemotherapy treatments. We hope to keep you informed with periodic reports in upcoming weeks.

September 8, 2006

Drs. Alain Theon and Gary Magdesian initiated Lost In The Fog’s chemotherapy at 11:30 AM Thursday, September 7 at the UC Davis Veterinary Medical Teaching Hospital.

In order to minimize side effects frequently encountered during, and within 24 hours after administration of the chemotherapeutic drug, doxorubicin (Adriamycin), Lost In The Fog was premedicated with dexamethasone (a corticosteroid), flunixin meglumine (Banamine, a non-steroidal anti-inflammatory drug), and diphenhydramine (Benadryl, an antihistamine) using a protocol that Dr. Theon has refined through many years of experience administering chemotherapy to horses. The entire dose of doxorubicin was administered slowly over a 1-hour period via an intravenous catheter, and a constant intravenous infusion of saline was maintained during this time. Additional doses of Banamine and Benadryl were administered during the afternoon. Intravenous fluid therapy was continued overnight.

Lost In The Fog tolerated the treatment extremely well and remained comfortable throughout. He remained bright and alert overnight, maintained a normal temperature, and had an excellent appetite and attitude.

Lost In The Fog was released from the teaching hospital at 11:45 AM Friday, September 8, into the care of his trainer, Mr. Greg Gilchrist, and his veterinarian, Dr. Don Smith, who will monitor the horse closely at Golden Gate Fields. Dr. Smith will collect blood at regular intervals to monitor the effects of the first round of chemotherapy.

Subsequent chemotherapy treatments will be scheduled based on the results of these blood tests and on Lost In The Fog’s progress. Lost In The Fog will receive prednisolone, a second corticosteroid drug, in a reducing dose schedule orally once daily for the next 10 days. One or two additional chemotherapeutic drugs, vincristine (Oncovin) and cyclophosphamide (Cytoxan), may be added to the chemotherapy regimen in the weeks ahead, pending results of blood tests, detailed physical examinations and ultrasound examinations.

Lost In The Fog was a model patient while hospitalized at the VMTH and behaved very well. He will, no doubt, enjoy his return to the familiar environment and faces in Mr. Gilchrist’s barn at Golden Gate Fields.

The dedicated veterinarians and staff who have provided Lost In The Fog with round-the-clock care during his visits to the Veterinary Medical Teaching Hospital are rooting for him. We sincerely appreciate the messages of support and encouragement that have poured in from Lost In The Fog’s many fans and admirers around the globe.

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