Alternative Treatment for Urinary Tract Infections in Dogs
Dr. Jodi Westropp of UC Davis School of Veterinary Medicine seeks at least 20 dogs with suspected urinary tract infections (UTIs) for help with a study designed to improve the treatment of dogs with simple urinary tract infections.
Clinical signs of dogs with UTIs can include bloody urine, accidents in the house, and/or small amounts of urine frequently. If you feel your dog has a UTI, please contact Dr. Westropp at the number or email listed below.
Veterinarians: If you have a canine patient where an uncomplicated UTI is suspected, please contact Dr. Westropp. You will receive compensation for enrolling this patient in the study and all exams and diagnostics related to the study are free for your client. Owners will need to bring their dogs to the UC Davis School of Veterinary Medicine in Davis for evaluations.
Dr. Westropp's team is hoping to determine if using a different drug over a shorter time period is as effective as current treatment. Both treatment groups involve drugs and doses that are currently labeled for treatment of UTIs in dogs. If the study is successful, veterinarians may be able to offer a treatment with the potential to limit the emergence of resistant organisms and to increase owner ease of treatment of bladder infections.
To learn if your dog (or your patient) qualifies, please review the study description:
A Prospective, Positive Controlled, Randomized, Parallel-armed and Masked Clinical Trial Designed to Evaluate the Efficacy and Safety of an Alternative Antibiotic Treatment Regimen for Lower Urinary Tract Infection in Dogs
Purpose of Study
The objective of this study is to evaluate the safety and effectiveness of an alternative antibiotic treatment protocol for uncomplicated lower urinary tract (bladder) infection in dogs.
A bacterial Infection in the lower urinary tract involves the bladder and urethra, which most often is resolved by administering antibiotics. Veterinarians are increasingly interested in dosing programs that reduce the time that animals and bacteria are exposed to antibiotics in order to minimize the risk of resistance development.
If the alternative antibiotic protocol is equally effective to a standard antibiotic administration, this could provide an option to the typical treatment of bladder infections. The alternative antibiotic administration schedule has the potential to limit the emergence of resistant organisms and to increase owner ease of treatment of bladder infections
To qualify for enrollment in this study, dogs must:
• Weigh 5-50kgs
• Have an uncomplicated bacterial lower urinary tract infection (LUTI). Dogs with persistent or recurrent LUTI based on clinical history are not candidates
• Not have chronic pyelonephritis, prostatitis, urinary tract neoplasia or calculi
• Have not been treated within 7 days with any short duration systemic antimicrobial or last 14 days with any long-duration systemic antimicrobial
• Have not been treated within the last 14 days with a systemic short-acting steroidal anti-inflammatory product or within the last 28 days with a systemic sustained-release steroidal anti-inflammatory product
• Initial evaluation to determine if your dog is eligible for enrollment.
• If your dog fulfils all criteria for inclusion in the study he or she will be randomly assigned to a study group (both groups receive antibiotic treatment; all drugs are FDA approved)
• Follow up evaluations will take place on days 10 and 21. A physical examination and LUTI scoring will be performed, and urine samples will be collected for urinalysis as well as bacterial culture and antimicrobial susceptibility testing
• The study will cover most costs related to the clinical trial including:
• Initial visit: Evaluation and LUTI scoring, CBC, chemistry, urinalysis, urine culture and sensitivity, and study medication
• Two follow -up visits: Evaluations with LUTI scoring, urinalysis, and urine culture and sensitivity
• If your dog experiences treatment-related side effects, the study will pay for veterinary care and connected expenses
• The study will not cover evaluations for other problems not related to the lower urinary tract, or if your pet becomes ineligible and further evaluation or treatment is needed
• Owners must sign a consent form, be willing and able to comply with the established treatment procedure and schedule, complete the associated documentation, return for follow-up visits, and return study documentation and unused medication
Thank you for your assistance in identifying appropriate subjects for this clinical study to help improve the health of dogs.
For more information on this study, please contact:
• Dr. Jodi Westropp
• John Kirby