Iannis E Adamopoulos BSc(Hons), M.Phil, D.Phil
Division of Rheumatology, Allergy and Clinical Immunology
School of Medicine, University of California at Davis
Osteoimmunology (see also: biochemistry, immunology, translational research and osteoimmunology)
Our laboratory studies the interface between the skeletal and immune systems, a newly emerging area of research called “osteoimmunology”. Haematopoietic stem cells in the bone marrow give rise to both T cells which are important in inflammation and osteoclasts that regulate bone resorption. Differentiation and activation of osteoclasts from their precursors is tightly regulated by cytokines and growth factors such as receptor activator of nuclear factor kappa beta (RANKL), tumor necrosis factor (TNF) and various interleukins. Receptor engagement of these molecules results in signaling cascades and transcriptional changes that give rise to medical conditions such as rheumatoid arthritis, osteoporosis and osteopetrosis. Using in vivo gene transfer of immune cytokines IL-23 and IL-17, we have established new arthritis animal models that highlight the importance of these immune cytokines in arthritis initiation and bone homeostasis. Using in vitro assays, we continue our attempts to define the cellular and molecular mechanisms that take place in this fascinating interplay of the immune and skeletal systems.
Fu-Tong Liu, M.D., Ph.D.
Fu-Tong Liu, MD PhD, is a dermatologist/immunologist currently serving as Distinguished Professor and Chair Emeritus of the Department of Dermatology in the School of Medicine at UC Davis. His primary research interests encompass molecular and cellular mechanisms of allergic disorders and this includes the studies of IgE, IgE receptors, and mast cells. Current projects in his lab related to this area include the studies of mouse models of atopic dermatitis and the mechanism of anti-IgE therapy for allergy. In addition, his group is heavily involved in the investigation of expression, structure and function of a family of animal lectins, galectins. The research is focused on the roles of galectin-3, -7, -9, and -12 in inflammation, infection, skin diseases, and cancer.
Please visit Dr. Liu website at: http://www.ucdmc.ucdavis.edu/dermatology/faculty/liu.html