Event Date
MIC (Microbiology Course) 291- Selected Topics in Microbiology
Work-in-Progress Seminars
Karine Gaëlle Le Roch, Ph.D, Professor of Molecular, Cell and Systems Biology, Director of the Center for Infectious Disease and Vector Research, University of California, Riverside presents: "A Systems Biology Approach to Antimalarial Drug Discovery"
About the speaker:
Over the past 20 years, I gained broad expertise in drug discovery, cell cycle regulation, epigenomics and functional genomics in eukaryotic organisms with a particular interest for Plasmodium falciparum, the protozoan parasite that cause the deadliest form of malaria in humans. I first investigated the role of protein kinases and signal transduction in Plasmodium life cycle. I cloned and characterized the first cyclin dependent kinase in P. falciparum. As a post-doctoral fellow, I used advanced microarray technologies to identify functional information to more than 1,000 hypothetical proteins throughout the parasite life cycle. Following this work, I became an Institute Researcher at the Genomics Institute of the Novartis Research Foundation (GNF), San Diego, California where I furthered my work on kinases and kinase inhibitors and set up the basis of malaria drug discovery program at Novartis. Since April 2006, as an Assistant, Associate, and now Professor and Director of the Center for Infectious Disease and Vector Research at the University of California Riverside (UCR), I expanded my research scope by developing new high-throughput methodologies to investigate epigenetic and chromatin features in host-pathogen interactions to identify key molecular pathways underlying pathogen and host cell development. As PI or co-PI of well-funded projects, I successfully administered, collaborated and published a high number of high impact peer-reviewed articles. My expertise in cellular and molecular biology techniques as well as my in-depth experience acquiring, handling and analyzing large genome-wide datasets from a wide array of samples and techniques have been demonstrated with over 100 peer-reviewed publications and proceedings, 9 book chapters and one US patent.
This event is free to attend.
Host: Scott Dawson ([email protected]) Professor of Microbiology and Molecular Genetics
