Important Updates

Michael L Goodson

Michael L Goodson

Associate Project Scientist

Anatomy, Physiology & Cell Biology


Education
1993, BS, University of Illinois, Urbana-Champaign
2000, PhD, University of Kentucky Chandler Medical School, Lexington, KY
2006, Postdoctoral Training, University of California, Davis, Davis, CA
Most Recent Five Book Chapters
2009 Goodson ML : Model Organisms for Life Science Research, Katherine E. Cullen, (ed), Encyclopedia of Life Science, New York, NY. 674-5.
Research Focus
Metabolic Physiology and the Gut Microbiome: The long-term aim of my research is to understand how organisms integrate the myriad of diet, endocrine and environmental signals to coherently regulate energy homeostasis and to understand how disruption of this homeostasis leads to different metabolic pathologies. I am currently interested in understanding how bidirectional interactions between the host and microorganisms within the host control a diverse array of metabolic and other physiologic processes and how perturbations in these interactions leads to various diseases.
Specialty Focus
The focus of my research involves exploring how macronutrients and other factors within the foods we eat interact with both the intestinal tissue and intestinal microbita to alter both neurobiology of feeding behavior and glucose homeostatic control and understanding how dysregulation by these diet components leads to metabolic pathologies, including diabetes and obesity. To accomplish this, I use various mouse models of obesity, diabetes and gut-brain signalling.
Ten Recent Publications

2019
Privalsky ML, Goodson ML
Evolution of NCoR-1 and NCoR-2 Corepressor Alternative mRNA Splicing in Placental Mammals

2019
Larson KR, Chaffin AT, Goodson ML, Fang Y, Ryan KK
Fibroblast Growth Factor-21 Controls Dietary Protein Intake in Male Mice.

2018
Mengeling BJ, Goodson ML, Furlow JD
RXR Ligands Modulate Thyroid Hormone Signaling Competence in Young Xenopus laevis Tadpoles

2017
Larson KR, Russo KA, Fang Y, Mohajerani N, Goodson ML, Ryan KK
Sex Differences in the Hormonal and Metabolic Response to Dietary Protein Dilution

2017
Goodson ML, Packard AEB, Buesing DR, Maney M, Myers B, Fang Y, Basford JE, Hui DY, Ulrich-Lai YM, Herman JP, Ryan KK
Chronic stress and Rosiglitazone increase indices of vascular stiffness in male rats

2016
Kieffer DA, Piccolo BD, Marco ML, Kim EB, Goodson ML, Keenan MJ, Dunn TN, Knudsen KE, Martin RJ, Adams SH
Mice Fed a High-Fat Diet Supplemented with Resistant Starch Display Marked Shifts in the Liver Metabolome Concurrent with Altered Gut Bacteria.

2016
Kieffer DA, Piccolo BD, Marco ML, Kim EB, Goodson ML, Keenan MJ, Dunn TN, Knudsen KE, Adams SH, Martin RJ
Obese Mice Fed a Diet Supplemented with Enzyme-Treated Wheat Bran Display Marked Shifts in the Liver Metabolome Concurrent with Altered Gut Bacteria.

2016
Privalsky ML, Snyder CA, Goodson ML
Corepressor diversification by alternative mRNA splicing is species specific.

2015
Snyder CA, Goodson ML, Schroeder AC, Privalsky ML
Regulation of corepressor alternative mRNA splicing by hormonal and metabolic signaling.

2014
Goodson ML, Young BM, Snyder CA, Schroeder AC, Privalsky ML
Alteration of NCoR Corepressor Splicing in Mice Causes Increased Body Weight and Hepatosteatosis without Glucose Intolerance