Michael L Goodson

Education

1993, BS, University of Illinois, Urbana-Champaign

2000, PhD, University of Kentucky Chandler Medical School, Lexington, KY

2006, Postdoctoral Training, University of California, Davis, Davis, CA

Active Research Grants

Other, National Centers for Metabolic Phenotyping in Live Models of Obesity and Diabetes (MPMOD), KC Kent Lloyd (Principal Investigator), National Institutes of Health

Most Recent Five Book Chapters

2009 Goodson ML: Model Organisms for Life Science Research, Katherine E. Cullen, (ed), Encyclopedia of Life Science, New York, NY. 674-5.

Research Focus

Metabolic Physiology and the Gut Microbiome: The long-term aim of my research is to understand how organisms integrate the myriad of diet, endocrine and environmental signals to coherently regulate energy homeostasis and to understand how disruption of this homeostasis leads to different metabolic pathologies. I am currently interested in understanding how bidirectional interactions between the host and microorganisms within the host control a diverse array of metabolic and other physiologic processes and how perturbations in these interactions leads to various diseases.

Specialty Focus

The focus of my research involves exploring how macronutrients and other factors within the foods we eat interact with both the intestinal tissue and intestinal microbita to alter both neurobiology of feeding behavior and glucose homeostatic control and understanding how dysregulation by these diet components leads to metabolic pathologies, including diabetes and obesity. To accomplish this, I use various mouse models of obesity, diabetes and gut-brain signalling.

Ten Recent Publications

2023
Sandoval S, Malany K, Thongphanh K, Martinez CA, Goodson ML, Souza FDC, Lin LW, Pennington J, Lein PJ, Kerkvliet NI, Ehrlich AK
Activation of the aryl hydrocarbon receptor inhibits neuropilin-1 upregulation on IL-2 responding CD4 + T cells.

2022
Chaffin AT, Larson KR, Huang KP, Wu CT, Godoroja N, Fang Y, Jayakrishnan D, Soto Sauza KA, Sims LC, Mohajerani N, Goodson ML, Ryan KK
FGF21 controls hepatic lipid metabolism via sex-dependent interorgan crosstalk.

2022
Wu CT, Larson KR, Goodson ML, Ryan KK
Fibroblast Growth Factor 21 And Dietary Macronutrient Intake In Female Mice.

2021
Heiss BE, Ehrlich AM, Maldonado-Gomez MX, Taft DH, Larke JA, Goodson ML, Slupsky CM, Tancredi DJ, Raybould HE, Mills DA
Bifidobacterium catabolism of human milk oligosaccharides overrides endogenous competitive exclusion driving colonization and protection.

2021
Huang KP, Goodson ML, Vang W, Li H, Page AJ, Raybould HE
Leptin signaling in vagal afferent neurons supports the absorption and storage of nutrients from high-fat diet.

2021
Lee S, Goodson ML, Vang W, Rutkowsky J, Kalanetra K, Bhattacharya M, Barile D, Raybould HE
Human milk oligosaccharide 2'-fucosyllactose supplementation improves gut barrier function and signaling in the vagal afferent pathway in mice.

2020
Ehrlich AM, Pacheco AR, Henrick BM, Taft D, Xu G, Huda MN, Mishchuk D, Goodson ML, Slupsky C, Barile D, Lebrilla CB, Stephensen CB, Mills DA, Raybould HE
Indole-3-lactic acid associated with Bifidobacterium-dominated microbiota significantly decreases inflammation in intestinal epithelial cells.

2020
Goodson ML, Knotts TA, Campbell EL, Snyder CA, Young BM, Privalsky ML
Specific ablation of the NCoR corepressor d splice variant reveals alternative RNA splicing as a key regulator of hepatic metabolism.

2020
Lee S, Goodson M, Vang W, Kalanetra K, Barile D, Raybould H
2'-fucosyllactose Supplementation Improves Gut-Brain Signaling and Diet-Induced Obese Phenotype and Changes the Gut Microbiota in High Fat-Fed Mice.

2020
Lee S, Knotts TA, Goodson ML, Barboza M, Wudeck E, England G, Raybould HE
Metabolic Responses to Butyrate Supplementation in LF- and HF-Fed Mice Are Cohort-Dependent and Associated with Changes in Composition and Function of the Gut Microbiota.