Pamela J Lein

Professor

Molecular Biosciences

Office
2009 Vet Med 3B, Davis, CA 95616

Education
1992, Postdoctroal training, Roswell Park Cancer Institute, Buffalo, NY
1990, PhD, State University of New York at Buffalo, Buffalo, NY
1983, MS, East Tennessee Stat University, Johnson City, TN
1981, BS, Cornell University, Ithaca, NY
Active Research Grants
Co-Principal Investigator, The UC Davis Center for Children’s Environmental Health and Disease Prevention, Van de Water (Principal Investigator), NIH/NIEHS and USEPA
Co-Principal Investigator, MIND Institute Intellectual and Developmental Disabilities Research Center (IDDRC), Abbeduto (Principal Investigator), NIH/NICHD
Principal Investigator, OPs and autism-linked neuroligin mutations interact to impair synaptogenesis, (Principal Investigator), Jane Botsford Johnson Foundation
Principal Investigator, Molecular and Cellular Basis of PCB Developmental Neurotoxicity , (Principal Investigator), NIH/NIEHS
Co-Investigator, Linking Environmental Exposures to Mechanisms of Disease across Life Stages, Hertz-Picciotto (Principal Investigator), NIH/NIEHS
Co-Investigator, Perinatal DDT exposure causes insulin resistance in adult mice through impaired thermogenesis, La Merrill, Michele (Principal Investigator),
Principal Investigator, Does air pollution increase risk of AD in a genetically susceptible animal model?, (Principal Investigator),
Principal Investigator, Novel Anticonvulsant and Neuroprotective Therapies for TETS and OP Intoxication, (Principal Investigator),
Co-Investigator, Phenotypic Characterization of Novel Models of Dup15q Syndrome, Silverman, Jill (Principal Investigator),
Principal Investigator, Influence of air pollution on AD phenotype in a genetically susceptible rat model, (Principal Investigator),
Principal Investigator, Molecular and Cellular Basis of PCB Developmental Neurotoxicity: ViCTER supplement, (Principal Investigator),
Honors and Awards
1987-1990 March of Dimes Predoctoral Fellowship
1991 NIH NCI National Research Service Award, Cell biology of human TILs engrafted into SCID mice (1F32 CA09177-01)
1994 National Science Foundation Research Opportunity Award, $10,000
1994-1997 Grass Fellowship Exchange, The Grass Foundation, $6,000
1995-1996 Dean's Grant, Arts and Sciences, Canisius College, $5000
1996-1999 Howard Hughes Medical Institute Program for Undergraduate Science Education, Co-PI, $650,000
1998-1999 NSF ILI grant, Incorporation of imaging techniques into undergraduate cell and molecular laboratories (DUE-9850762, PI, $26,297
2014 Lesiak A, Zhu M, Chen H, Appleyard SM, Impey S, Lein PJ*, Wayman GA (2014) * Corresponding author. The environmental neurotoxicant PCB 95 promotes synaptogenesis via ryanodine receptor-dependent miR132 upregulation. J Neurosci 34(3): 717-25. This article was selected as the editor’s highlight for this issue.
2014 Yang D, Kania-Korwel I, Ghogha A, Chen H, Stamou M, Bose DD, Pessah IN, Lehmler HJ, Lein PJ (2014) PCB136 atropselectively alters morphometric and functional parameters of neuronal connectivity in cultured rat hippocampal neurons via ryanodine receptor-dependent mechanisms. Toxicol Sci 138(2):379-392. This article was selected as the editor’s highlight for this issue.
2015 Zoetis Award for Veterinary Research Excellence, UC Davis School of Veterinary Medicine
2017 Chen H, Streifel KM, Singh V, Yang D, Mangini L, Wulff H, Lein PJ (2017) BDE-47 and BDE-49 inhibit axonal growth in primary rat hippocampal neuron-glia co-cultures via ryanodine receptor-dependent mechanisms. Toxicol Sci 156(2):375-386. An image from this article was featured on the cover of this issue.
2017 Siso S*, Hobson BA*, Harvey DJ, Bruun DA, Rowland DJ, Garbow JR, Lein PJ (2017) Spatiotemporal progression and remission of lesions in the rat brain following acute intoxication with diisopropylfluorophosphate. Toxicol Sci 157(2):330-341. *Co-first authors. This article was selected as the editor’s highlight for this issue.
2017 Hobson BA, Siso S, Rowland DJ, Harvey DJ, Bruun DA, Garbow JR, Lein PJ (2017) Longitudinal monitoring by magnetic resonance imaging reveals progressive brain injury in rats acutely intoxicated with diisopropylfluorophosphate. Toxicol Sci 157(2):342-353. PMC5458789 An image from this article was featured on the cover of this issue.
2017 Kania-Korwel I, Lukasiewicz T, Barnhart CD, Stamou M, Chung H, Kelly KM, Bandiera S, Lein PJ, Lehmler HJ (2017) Congener-specific disposition of chiral polychlorinated biphenyls in lactating mice and their offspring: Implications for PCB developmental neurotoxicity. Toxicol Sci 158(1):101-115. This article was selected as the editor’s highlight for this issue.
Most Recent Five Book Chapters
2017 Keil KP, Stamou M, Lein PJ : Chapter 22: Molecular mechanisms of neurotoxicity, Smart RC, Hodgson E, (ed), Molecular and Biochemical Toxicology, 5th edition, Somerset, NJ. 709-772.
2015 Baumann J, Dach K, Barenys M, Giersiefer S, Goniwiecha J, Lein PJ, Fritsche E : Application of the neurosphere assay for DNT hazard assessment: Challenges and limitations, Tiffany-Castiglioni E, Harry GJ, (ed), Methods in Pharmacology and Toxicology, New York, NY. 49-63.
2015 Lein PJ : Overview of the role of environmental factors in neurodevelopmental disorders, Costa LG, Aschner M, (ed), Environmental Factors in Neurodevelopmental and Neurodegenerative Disorders, Oxford, UK. 3-20.
2014 Banks CN, Rogawski MA, Yang D, Lein PJ : Tetramethylenedisulfotetramine, Wexler P, (ed), Encyclopedia of Toxicology, 3rd edition, Oxford, UK. 509-11.
2014 Spencer PS, Lein PJ : Neurotoxicity, Wexler P, (ed), Encyclopedia of Toxicology, 3rd edition, Oxford, UK. 521-37.
Research Focus
Cellular and molecular mechanisms of neurotoxicology; gene x environment interactions in neurodevelopmental disorders and neurodegenerative diseases; medical countermeasures for acute intoxication with seizurogenic compounds
Specialty Focus
Neurotoxicology, neuropharmacology, neuroinflammation