Stephen J McSorley

Stephen J McSorley

Professor

Anatomy, Physiology & Cell Biology

Office
County Rd 98 at Hutchison Drive, Davis, CA 95616

Education
1992, B.Sc., Glasgow University, Glasgow, Scotland
1996, Ph.D., Glasgow University, Glasgow, Scotland
Active Research Grants
Principal Investigator, Salmonella-specific Th1 cell function and residence, (Principal Investigator), NIH NIAID
Principal Investigator, Developing mouse models to study circulating memory to Chlamydia infection. , (Principal Investigator), NIH-NIAID
Most Recent Five Book Chapters
2012 Atif SM, McSorley SJ: TLR5, Choi S, (ed), Encyclopedia of Signaling Molecules, New York. 1875-1881.
2009 Moon JJ, McSorley SJ: Tracking the dynamics of salmonella specific T cell responses, , Curr Top Microbiol Immunol, . 179-98.
1998 McSorley SJ, Liew FYI: Leishmaniasis, Delves PJ, (ed), Encyclopedia of Immunology (Second Edition), . 1546–1551.
1998 McSorley SJ, F Liew Y: Nitric Oxide, Delves PJ, (ed), Encyclopedia of Immunology (Second Edition), . 1859–1861.
Research Focus
My research focuses on the innate and adaptive immune response to bacterial pathogens and largely uses mouse models of infection with Salmonella and Chlamydia. In close collaboration with the Center for Companion Animal Health I also generate caninized monoclonal antibodies for canine research, diagnostics, and therapeutic applications.
Specialty Focus

Immunology and Microbiology

Ten Recent Publications

2024
Lokken-Toyli KL, Diaz-Ochoa VE, Camacho L, Stull-Lane AR, Van Hecke AER, Mooney JP, Munoz AD, Walker GT, Hampel D, Jiang X, Labuda JC, Depew CE, McSorley SJ, Stephensen CB, Tsolis RM
Vitamin A deficiency impairs neutrophil-mediated control of Salmonella via SLC11A1 in mice

2024
Rixon JA, Fong KD, Morris C, Nguyen AT, Depew CE, McSorley SJ^
Elimination of Chlamydia muridarum from the female reproductive tract is IL-12p40 dependent, but independent of Th1 and Th2 cells.

2023
Depew CE, McSorley SJ
The role of tissue resident memory CD4 T cells in Salmonella infection: Implications for future vaccines.

2023
Depew CE, Rixon JA, McSorley SJ^
Optimal generation of hepatic tissue-resident memory CD4 T cells requires IL-1 and IL-2.

2023
Depew CE, Nguyen AT, Franke MC, Calderon J, Sciammas R, McSorley SJ^
Cutting Edge: Optimal Formation of Hepatic Tissue-Resident Memory CD4 T Cells Requires T-bet Regulation of CD18.

2022
Liou MJ, Miller BM, Litvak Y, Nguyen H, Natwick DE, Savage HP, Jordan JA, Hiyoshi H, Rogers AWL, Velazquez EM, Butler BP, Collins SR, McSorley SJ, Harshey RM, Byndloss MX, Simon SI, Baumler AJ
Host cells subdivide nutrient-niches into discrete biogeographical microhabitats for gut microbes

2022
Rixon JA, Depew CE, McSorley SJ^
Th1 cells are dispensable for primary clearance of Chlamydia from the female reproductive tract of mice

2022
Labuda JC, Fong K, Mcsorley SJ^
Co-housing with dirty mice increases the frequency of memory T cells and has variable effects on intracellular bacterial infection.

2021
Peres NG, Wang N, Whitney P, Engel S, Shreenivas MM, Comerford I, Hocking DM, Erazo A, Forster I, Kupz A, Gebhardt T, McColl S, McSorley SJ, Bedoui S, Strugnell RA
CD4+ T cell immunity to Salmonella is transient in the circulation

2021
Shaan Lakshmanappa Y, Elizaldi SR, Roh JW, Schmidt BA, Carroll TD, Weaver KD, Smith JC, Verma A, Deere JD, Dutra J, Stone M, Franz S, Sammak RL, Olstad KJ, Reader JR, Ma Z, Nguyen NK, Watanabe J, Usachenko J, Immareddy R, Yee JL, Weiskopf D, Sette A, Hartigan-O’Connor D, McSorley SJ, Morrison JH, Tran NK, Simmons G, Busch MP, Kozlowski PA, Van Rompay KKA, Miller CJ, Iyer SS
SARS-CoV-2 induces robust germinal center CD4 T follicular helper cell responses in rhesus macaques