Elena N Dedkova

Elena N Dedkova

Researcher

Molecular Biosciences


Licenses
UC Davis Mentorship Academy, Certificate
UC Davis Biomedical Engineering Enterpreneurship Academy, Davis, CA, Certificate
Education
2006, American Heart Association Fellowship, Chicago, IL
2004, Loyola Univeristy Medical Center, Chicago, IL
1999, Ph.D., Institute of Cell Biophysics, Russian Academy of Sciences, Pushchino, Russia
1991, D.V.M., Moscow State Academy of Veterinary Medicine and Biotechnology, Moscow, Russia
1989, M.Sc., Moscow State Academy of Veterinary Medicine and Biotechnology, Moscow, Russia
Active Research Grants
Principal Investigator, Fumarate drugs rescue cardiac dysfunction in mouse models of Friedreich's ataxia, (Principal Investigator), National Institutes of Health (NIH)
Principal Investigator, Cardiac benefits of drugs that stimulate Nrf2 and HCA2 pathways in Friedreich's ataxia, (Principal Investigator), Friedreich's Ataxia Research Alliance (FARA)
Principal Investigator, Fumarate drugs rescue cardiac dysfunction in mouse models of Friedreich's ataxia, (Principal Investigator), American Heart Association (AHA)
Principal Investigator, Fumarate drugs rescue cardiac dysfunction in mouse models of Friedreich's ataxia, (Principal Investigator), National Institutes of Health (NIH), Diversity Supplement to the Parent R01 grant
Collaborator, Modeling of subcellular signaling crosstalk in failing myocytes, Stefano Morotti (Principal Investigator), National Institute of Health
Co-Investigator, Investigations of targets, mechanisms, and optimal delivery of therapeutic ketosis for functional longevity and treatment of Alzheimer's disease. , Gino Cortopassi (Principal Investigator), The National Institute of Health, NIA
Co-Principal Investigator, Role of the mitochondrial translocator protein (TSPO) in the development of heart failure, Saul Schaufer (Principal Investigator), AHA Transformational Award
Principal Investigator, Bone marrow Transplantation in Friedreich’s ataxia: Evaluation of therapeutic benefit in the inducible and reversible frataxin knockdown (FXNKD) mouse model, (Principal Investigator), Friedreich's Ataxia Research Alliance (FARA)
Principal Investigator, The monoamine oxidase-A inhibition to prevent cardiac arrhythmias in Friedreich’s ataxia., (Principal Investigator), UC Davis Innovative Development Award
Honors and Awards
1996-1998 Jorge Soros Award, Advanced Postgraduate Students, Moscow
1999-2020 FEBS Award, Participation in FEBS Advanced Course: Free Radicals, Nitric Oxide and Antioxidants in Health and Disease
2004-2006 AHA Greater Midwest Affiliate, Postdoctoral Fellowship
2007 AHA Greater Midwest Scientist Development Grant, Mechanisms of mitochondria-mediated cardioprotection by trimetazidine in ventricular myocytes
2016-2017 Selected trainee from UC Davis, NRMN-P3 grant writing training, sponsored by the NIH
2018-2019 Academic Federation Research Travel Grant Award, Academic Federation Committee on Research, Davis, CA
2019-2020 Academic Federation Research Travel Grant Award, Academic Federation Committee on Research, Davis, CA
2020-2021 Academic Federation Research Travel Grant Award, Academic Federation Committee on Research, Davis, CA
2021-2022 Academic Federation Research Travel Grant Award, Academic Federation Committee on Research, Davis, CA
Most Recent Five Book Chapters
2016 Seidlmayer LK, Dedkova EN^: Chapter 7, Inorganic Polyphosphates in the Mitochondria of Mammalian Cells, Seidlmayer LK, Dedkova EN, (ed), Inorganic Polyphosphates in Eukaryotic Cells, Switzerland. 91-114.
2014 Dedkova EN, Blatter LA: Role of beta-hydroxybutyrate and inorganic polyphosphate in cardiovascular health and disease, Aon MA, Camara AKS, (ed), Mitochondria: Hubs of cellular signaling, energetics and redox balance. E-book, 17 July 2014, Switzerland. 260.
Research Focus
My research is focusing on pharmacokinetics and pharmacodynamics of this novel drug, safety, toxicology, and the mechanisms of cardioprotective action
Specialty Focus
Cardiovascular Physiology, Pharmacology, Mitochodrial Function, Heart Failure, Ketogenic diet and Cardiac Function
Ten Recent Publications

2025
Salinas L., Figueroa F., Montgomery C.B., Thai P.N., Chiamvimonvat N., Cortopassi G., Dedkova E.N.
Omaveloxolone, but not dimethyl fumarate, improves cardiac function in Friedreich’s ataxia mice with severe cardiomyopathy.

2025
Montgomery C.B., Salinas L., Cox G.P., Adcock L.E., Chang T., Figueroa F., Cortopassi G., Dedkova E.N.
Robust behavioral assessment of the inducible Friedreich's ataxia mouse does not show improvement with NRF2 induction.

2025
Figueroa F., Thai P.N., Salinas S, Montgomery C.B., Chiamvimonvat N., Cortopassi G., Dedkova E.N.
Poincare plot analysis of ECG uncovers beneficial effects of omaveloxolone in a mouse model of Friedreich’s ataxia.

2024
Salinas L., Montgomery C.B., Figueroa F., Thai P.N., Chiamvimonvat N., Cortopassi G., Dedkova E.N.
Sexual dimorphism in a mouse model of Friedreich’s Ataxia with severe cardiomyopathy.

2022
Voglhuber J, Holzer M, Radulovic S, Thai PN, Djalinac N, Matzer I, Wallner M, Bugger H, Zirlik A, Leitinger G, Dedkova EN, Bers DM, Ljubojevic-Holzer S
Functional remodeling of perinuclear mitochondria alters nucleoplasmic Ca2+ signaling in heart failure.

2022
Ren L, Gopireddy RR, Perkins G, Zhang G, Timofeyev V, Lyu Y, Sirish DP, Overton JL, Xu W, Grainfer N, Xiang YK, Dedkova EN, Yamoah EN, Navedo MF, Thai PN, Chiamvimonat N
Disruption of mitochondria-sarcoplasmic reticulum microdomain connectomics contributes to sinus node dysfunction in heart failure

2021
Thai PN, Miller CV, Schaefer S, King MT, Veech RL, Chiamvimonvat N, Bers DM, Dedkova EN
Ketone Ester D-ß-Hydroxybutyrate-(R)-1,3 Butanediol Prevents Decline in Cardiac Function in Type 2 Diabetic Mice

2021
Seidlmayer LK, Hanson BJ, Thai PN, Schaefer S, Bers DM, Dedkova EN
PK11195 protects from cell death only when applied during reperfusion: succinate-mediated mechanism of action

2021
Hui CK, Dedkova EN, Montgomery C, Cortopassi G
Dimethyl fumarate dose-dependently increases mitochondrial gene expression and function in muscle and brain of Friedreich's ataxia model mice.

2021
Yang L, Dedkova EN, Allen PD, Jafri MS, Fomina AF
T lymphocytes from malignant hyperthermia-susceptible mice display aberrations in intracellular calcium signaling and mitochondrial function.