Elena Dedkova

Professional Researcher

Molecular Biosciences

1989, M.Sc., Moscow State Academy of Veterinary Medicine and Biotechnology, Moscow, Russia
1991, D.V.M., Moscow State Academy of Veterinary Medicine and Biotechnology, Moscow, Russia
1999, Ph.D., Institute of Cell Biophysics, Russian Academy of Sciences, Pushchino, Russia
2004, Loyola Univeristy Medical Center, Chicago, IL
2006, American Heart Association Felowship, Chicago, IL
2019, Certificate, UC Davis Biomedical Engineering Enterpreneurship Academy, Davis, CA
Active Research Grants
Collaborator, Molecular examination of mitochondrial calcium control, Molkentin/Bers (multi-PI) (Principal Investigator), National Institute of Health
Collaborator, Modeling of subcellular signaling crosstalk in failing myocytes, Stefano Morotti (Principal Investigator), National Institute of Health
Principal Investigator, Can ketones rescue heart failure? , (Principal Investigator), UC Davis Innovative Development Award
Co-Principal Investigator, Role of the mitochondrial translocator protein (TSPO) in the development of heart failure, Saul Schaufer (Principal Investigator), AHA Transformational Award
Co-Investigator, Investigations of targets, mechanisms, and optimal delivery of therapeutic ketosis for functional longevity and treatment of Alzheimer's disease. , Gino Cortopassi (Principal Investigator), The National Institute of Health, NIA
Co-Investigator, Friedreich’s Ataxia, mitochondrial biogenesis and neurodegeneration, Gino Cortopassi (Principal Investigator), National Institute of neurological disorders and stroke
Principal Investigator, Cardiac benefits of drugs that stimulate Nrf2 and HCA2 pathways in Friedreich's ataxia. , (Principal Investigator), FARA Research Grant
Principal Investigator, Fumarate drugs rescue cardiac dysfunction in mouse models of Friedreich's ataxia, (Principal Investigator), American Heart Association
Principal Investigator, Fumarate drugs rescue cardiac dysfunction in mouse models of Friedreich's ataxia, (Principal Investigator),
Honors and Awards
2013 Co-chair, Session “Role of mitochondria in cell death” at the 57th Annual Meeting of Biophysical Society, February 2-13, 2013, Philadelphia, PA
2015 Chair, University Council Meeting, Rush University Chicago
2016-2017 Selected trainee from UC Davis for the NRMN-P3 grant writing training, sponsored by the NIH
2015 Selected Junior Faculty Member for Rush University Medical School, Dean's Search Committee
Most Recent Five Book Chapters
2016 Seidlmayer LK, Dedkova EN: “Inorganic Polyphosphates in the Mitochondrai of Mammalian Cells”, Chapter 7, “Inorganic Polyphosphates in the Mitochondria of Mammalian Cells”, , , Switzerland. .
Research Focus

The contribution of mitochondria to cardiovascular physiology and pathology has been my primarily focus for many years. Heart failure (HF) is the leading cause of death in the US and a major reason for hospital readmissions among people over age 65, according to the American Heart Association. Energetic failure is considered an important pathogenic and potentially therapeutic element of HF, raising the need to examine the role of substrate utilization and mitochondrial function in HF. I lead several research projects which are aimed to find a pharmacological intervention for HF by enhancing mitochondrial function or shifting substrate preferences towards ketone bodies utilization. One project is designed to test the use of ketone esters as a pharmacological tool to enhance ketones utilization in heart failure in order to support impaired metabolism in HF without a need to adhere to strict ketogenic diets. The second project investigates whether fumarate-based drugs can prevent lethal cardiomyopathy in Friedreich's ataxia. Friedreich's ataxia is neurodegenerative movement disorder which places children and young adults in the wheelchairs by the time they graduate from high school. There is no treatment that cures this devastating disease, and most patients die from cardiomyopathy in their 30s. This lethal cardiomyopathy is caused by deficient expression of just one mitochondrial protein called frataxin. We synthesized a drug that shows cardiac protection in animal models of Friedreich's ataxia. My research is focusing on pharmacokinetics and pharmacodynamics of this novel drug, safety, toxicology, and the mechanisms of cardioprotective action.

Specialty Focus

Cardiovascular Physiology, Pharmacology, Mitochodrial Function, Heart Failure, Ketogenic diet and Cardiac Function

Ten Recent Publications

Hui C.K., Dedkova E.N., Montgomery C., Cortopassi G.
Dimethyl fumarate dose-dependently increases mitochondrial gene expression and function in muscle and brain of Friedreich's ataxia model mice.

Yang L, Dedkova EN, Allen PD, Jafri MS, Fomina AF.
T lymphocytes from malignant hyperthermia-susceptible mice display aberrations in intracellular calcium signaling and mitochondrial function.

Seidlmayer LK, Mages C, Berbner A, Eder-Negrin P, Arias-Loza PA, Kaspar M, Song M, Dorn GW, Kohlhaas M, Frantz S, Maack C, Gerull B, Dedkova EN^
Mitofusin 2 Is Essential for IP3-Mediated SR/Mitochondria Metabolic Feedback in Ventricular Myocytes

Thai PN, Seidlmayer LK, Miller C, Ferrero M, Dorn GW, Schaefer S, Bers DM, Dedkova EN^
Mitochondrial Quality Control in Aging and Heart Failure: Influence of Ketone Bodies and Mitofusin-Stabilizing Peptides

Seidlmayer LK, Gomez-Garcia MR, Shiba T, Porter Jr GA, Pavlov EV, Bers DM, Dedkova EN^
Dual role of inorganic polyphosphate in cardiac myocytes: The importance of polyP chain length for energy metabolism and mPTP activation

Seidlmayer, LK, Kuhn, J, Berbner, A, Arias-Loza, PA, Williams, T, Kaspar, M, Czolbe, M, Kwong, JQ, Molkentin, JD, Heinze, KG, Dedkova, EN, Ritter, O
Inositol 1,4,5-trisphosphate-mediated sarcoplasmic reticulum-mitochondrial crosstalk influences adenosine triphosphate production via mitochondrial Ca2+ uptake through the mitochondrial ryanodine receptor in cardiac myocytes.

Duan, L, Perez, RE, Davaadelger, B, Dedkova, EN, Blatter, LA, Maki, CG
p53-regulated autophagy is controlled by glycolysis and determines cell fate.

Seidlmayer, LK, Juettner, VV, Kettlewell, S, Pavlov, EV, Blatter, LA, Dedkova, EN
Distinct mPTP activation mechanisms in ischaemia-reperfusion: contributions of Ca2+, ROS, pH, and inorganic polyphosphate.