Alexey A Tomilov

Associate Project Scientist

Molecular Biosciences

Office
3011 VM3B, Davis, CA 95616

Education
1995, BS, M.V. Lomonosov Academy of Fine Chemical Technology,, Moscow, Russia
1995, MS, Biotechnology/ Fine Organic Chemistry, Moscow, Russia
2000, PhD, Vavilov Institute of General Genetics, Laboratory of Genome Variability, Moscow, Russia
Active Research Grants
Co-Investigator, Targeting Shc to reduce inflammation and fibrosis in the aging liver, Torok, Cortopassi (Principal Investigator), NIH
Co-Investigator, Friedreich's ataxia, mitochondrial biogenesis, and neurodegeneration, Gino Cortopassi (Principal Investigator), NIH
Co-Investigator, Idebenone engages Shc protein not mitochondria to mediate cytoprotection and insulin sensitivity, Cortopassi and Hecht (Principal Investigator), NIH
Co-Investigator, Ketogenic dietary strategies to mitigate functional decline with aging and Alzheimer's disease, Cortopassi/Ramsey (Principal Investigator), NIH
Co-Investigator, Friedreich's ataxia, mitochondrial biogenesis, and neurodegeneration, Gino Cortopassi (Principal Investigator), NIH
Co-Investigator, Investigations of targets, mechanisms, and optimal delivery of therapeutic ketosis for functional longevity and treatment of Alzheimer's disease, Cortopassi/Ramsey (Principal Investigator), NIH
Co-Investigator, A ketogenic longevity diet for resistance to age-related functional decline and Alzheimer's disease, Cortopassi/Ramsey (Principal Investigator), NIH
Co-Investigator, Pharmacodynamics and in vivo efficacy of fumarate for mitochondrial disease in vivo, Gino Cortopassi (Principal Investigator), NIH
Co-Investigator, A drug for mitochondrial biogenesis in humans for muscle disease, Gino Cortopassi (Principal Investigator), NIH
Co-Investigator, Shc inhibitors for Fatty Liver disease and Alzheimer’s disease, Gino Cortopassi (Principal Investigator), UC Drug Discovery Consortium
Co-Investigator, Idebenone engages Shc protein not mitochondria to mediate insulin sensitivity and cytoprotection, Cortopassi/Hecht (Principal Investigator), NIH
Co-Investigator, Geroscience of therapeutic ketosis and mTORC1 inhibition in Alzheimer's Disease, Gino Cortopassi (Principal Investigator), NIH
Co-Investigator, Shc blockade as an anti-aging strategy for increasing insulin sensitivity and reducing frailty, Gino Cortopassi (Principal Investigator), NIH
Co-Investigator, Pharmacodynamics and in vivo efficacy of fumarate for mitochondrial disease in vivo, Gino Cortopassi (Principal Investigator), NIH
Co-Investigator, Investigation of a non-mitochondrial target for idebenone, Cortopassi/Hecht (Principal Investigator), NIH
Co-Investigator, Ketogenic strategies to promote functional longevity and mitigate Alzheimer's disease, Cortopassi/Ramsey (Principal Investigator), NIH
Co-Investigator, Mitochondrial mechanisms in optic neuropathy, Gino Cortopassi (Principal Investigator), NIH
Honors and Awards
1997 Travel grant for young scientists from International Centre for Genetic Engineering and Biotechnology and travel grant for young scientists from Vavilov Institute of General Genetics, Russian Academy of Sciences to attend meeting of International Centre for Genetic Engineering and Biotechnology “Transformation Methods and Analysis of Gene Expression in Transgenic Plants” CENARGEN/EMBRAPA, Brasilia, Brazil, October 197
Research Focus
Organisms: plants, animals, fungi or bacteria are reacting on multiple exogenous stimuli by induction of network of endogenous processes. This includes signal transduction events which bring the organism in balance with the outside world, maintain balanced growth and development of the organism. While in plants there are only five major hormones: auxin, cytokinin, ABA, ethylene and gibberellins, in animals the signal transduction is more complex. Activation of different signal transduction pathways have different effects on cells and whole system and might be antagonistic, pleiotropic, collinear or complementary, and this forms really complicated network of regulatory processes in biological organism. Defects of signal transduction pathways mostly leads to disease, but current studies have developed interventions in signal transduction which lead to increased longevity and fitness. My interests are signal transduction pathways in biological systems and fitness improving manipulations with genes involved in regulation of the signaling events.
Specialty Focus
Genetics