Chris Miller

Chris Miller

Professor

Pathology, Microbiology & Immunology


Education
1982, BS, University of California, Davis,
1987, DVM, University of California, Davis,
1991, PhD, University of California, Davis,
Active Research Grants
Principal Investigator, Preclinical studies of COVID interventions, (Principal Investigator), Bioqual Inc
Co-Investigator, California National Primate Research Center – Base Grant, Mohapatra, Prasant (Principal Investigator),
Co-Investigator, Prevention of HIV-1 transmission by small-molecule CD4-mimetic entry inhibitors , Navid Madani (Principal Investigator), NIH
Principal Investigator, Testing Coronavirus drugs in animal models , (Principal Investigator), Global Health Drug Discovery Institute (GHDDI)
Principal Investigator, Bpcov2 mRNA Vaccine, (Principal Investigator), Bionet-Asia
Research Focus
Dr. Miller's research is focused on primate models of human viral diseases, and the immunopathology and pathogenesis of diseases caused by lentiviruses in particular. He has a focused emphasis on the rhesus macaque model of human acquired immunodeficiency syndrom (AIDS) and on mucosal immunity in the genital tract.
Specialty Focus
SIV pathogenesis, influenza A, HSV-2, vaccines
Ten Recent Publications

2022
Carroll T, Fox D, van Doremalen N, Ball E, Morris MK, Sotomayor-Gonzalez A, Servellita V, Rustagi A, Yinda CK, Fritts L, Port JR, Ma ZM, Holbrook MG, Schulz J, Blish CA, Hanson C, Chiu CY, Munster V, Stanley S, Miller CJ^
The B.1.427/1.429 (epsilon) SARS-CoV-2 variants are more virulent than ancestral B.1 (614G) in Syrian hamsters

2021
Shaan Lakshmanappa Y, Elizaldi SR, Roh JW, Schmidt BA, Carroll TD, Weaver KD, Smith JC, Verma A, Deere JD, Dutra J, Stone M, Franz S, Sammak RL, Olstad KJ, Reader JR, Ma ZM, Nguyen NK, Watanabe J, Usachenko J, Immareddy R, Yee JL, Weiskopf D, Sette A, Hartigan-O'Connor D, McSorley SJ, Morrison JH, Tran NK, Simmons G, Busch MP, Kozlowski PA, Van Rompay KKA, Miller CJ^, Iyer SS
SARS-CoV-2 induces robust germinal center CD4 T follicular helper cell responses in rhesus macaques.

2021
Newman CM, Tarantal AF, Martinez ML, Simmons HA, Morgan TK, Zeng X, Rosinski JR, Bliss MI, Bohm EK, Dudley DM, Aliota MT, Friedrich TC, Miller CJ, O'Connor DH
Early Embryonic Loss Following Intravaginal Zika Virus Challenge in Rhesus Macaques.

2021
Deere JD, Carroll TD, Dutra J, Fritts L, Sammak RL, Yee JL, Olstad KJ, Reader JR, Kistler A, Kamm J, Di Germanio C, Shaan Lakshmanappa Y, Elizaldi SR, Roh JW, Simmons G, Watanabe J, Pollard RE, Usachenko J, Immareddy R, Schmidt BA, O'Connor SL, DeRisi J, Busch MP, Iyer SS, Van Rompay KKA, Hartigan-O'Connor DJ, Miller CJ^
SARS-CoV-2 Infection of Rhesus Macaques Treated Early with Human COVID-19 Convalescent Plasma.

2020
Quispe Calla NE, Vicetti Miguel RD, Fritts L, Miller CJ, Aceves KM, Cherpes TL
Exogenous sex steroids regulate genital epithelial barrier function in female rhesus macaques.

2020
Yee JL, Van Rompay KKA, Carpenter AB, Nham PB, Halley BM, Iyer SS, Hartigan-O'Connor DJ, Miller CJ, Roberts JA
SARS-CoV-2 surveillance for a non-human primate breeding research facility.

2019
Khan S, Lew I, Wu F, Fritts L, Fontaine KA, Tomar S, Trapecar M, Shehata HM, Ott M, Miller CJ, Sanjabi S
Low expression of RNA sensors impacts Zika virus infection in the lower female reproductive tract.

2019
Lo M, Zhu J, Hansen SG, Carroll T, Farr Zuend C, Nöel-Romas L, Ma ZM, Fritts L, Huang ML, Sun S, Huang Y, Koelle DM, Picker LJ, Burgener A, Corey L, Miller CJ^
Acute Infection and Subsequent Subclinical Reactivation of Herpes Simplex Virus 2 after Vaginal Inoculation of Rhesus Macaques

2018
Carroll TD, Jegaskanda S, Matzinger SR, Fritts L, McChesney MB, Kent SJ, Fairman J, Miller CJ^
A Lipid/DNA Adjuvant-Inactivated Influenza Virus Vaccine Protects Rhesus Macaques From Uncontrolled Virus Replication After Heterosubtypic Influenza A Virus Challenge

2018
Ciupe SM, Miller CJ, Forde JE
A Bistable Switch in Virus Dynamics Can Explain the Differences in Disease Outcome Following SIV Infections in Rhesus Macaques