Christine Toedebusch

Christine Toedebusch

Associate Professor

Surgical & Radiological Sciences


Licenses
Diplomate American College of Veterinary Internal Medicine - Neurology
California State Veterinary License
Education
2010, DVM, University of Wisconsin, Madison, WI
2011, Internship, Veterinary Specialty Hospital, San Diego, CA
2012, Fellow, University of Missouri, Columbia, MO
2017, PhD, University of Missouri, Columbia, MO
2018, Residency, University of Missouri, Columbia, MO
Active Research Grants
Principal Investigator, Characterization of canine glioma-associated microglia, (Principal Investigator), CCAH
Co-Investigator, Characterization of metabolic control of glioma stem cell growth kinetics, Ryan Toedebusch (Principal Investigator), CCAH
Co-Principal Investigator, Mechanism of protumorigenic glioma-associated microglia: Characterization of the role of olfactomedin-like 3, Luke Wittenburg (Principal Investigator), UCD Cancer Center
Principal Investigator, CTSC Biorepository Core Resource, (Principal Investigator), VMDO
Research Focus
Neuroimmunology and the role of microglia in canine and feline CNS health and disease, with a specific focus on the role of microglia in primary brain tumorigenesis.
Specialty Focus

Neurology & Neurosurgery

Ten Recent Publications

2018
Toedebusch CM, Snyder JC, Jones MR, Garcia VB, Johnson GC, Villalón EL, Coates JR, Garcia ML
Arginase-1 expressing microglia in close proximity to motor neurons were increased early in disease progression in canine degenerative myelopathy, a model of amyotrophic lateral sclerosis.

2017
Toedebusch CM, Bachrach MF, Garcia VB, Johnson GC, Katz ML, Shaw G, Coates JR, Garcia ML
Cerebrospinal fluid levels of phosphorylated neurofilament heavy as a diagnostic marker of canine degenerative myelopathy

2017
Villalon E, Jones MR, Sibigtroth C, Zino SJ, Dale JM, Landayan DS, Shen H, Cornelison DDW, Garcia ML
Muscle spindle alterations precede onset of sensorimotor deficits in Charcot-Marie-Tooth type 2E

2016
Shababi M, Feng Z, Villalon E, Sibigtroth CM, Osman EY, Miller MR, Williams-Simon PA, Lombardi A, Sass TH, Atkinson AK, Garcia ML, Ko CK, Lorson CL
Rescue of a mouse model of spinal muscular atrophy with respiratory distress type 1 by AAV9-IGHMBP2 is dose dependent

2014
Katz ML, Coates JR, Sibigtroth CM, Taylor JC, Carpentier M, Young WM, Wininger FA, Kennedy D, Vuillemenot BR, O’Neill CA
Enzyme replacement therapy attenuates disease progression in a canine model of late-infantile neuronal ceroid lipofuscinosis (CLN2 disease)

2013
Smith SMC, Mitchell GS, Friedle SA, Sibigtroth CM, Vinit S, Watters JJ
Hypoxia attenuates puriergic P2X receptor induced inflammatory gene expression in brainstem microglia

2011
Sibigtroth CM, Mitchel GS
Carotid body chemoafferent activity is not necessary for phrenic long-term facilitation following intermittent hypoxia