Christine Toedebusch

Assistant Professor

Surgical & Radiological Sciences

Diplomate American College of Veterinary Internal Medicine - Neurology
California State Veterinary License
2010, DVM, University of Wisconsin, Madison, WI
2011, Internship, Veterinary Specialty Hospital, San Diego, CA
2012, Fellow, University of Missouri, Columbia, MO
2017, PhD, University of Missouri, Columbia, MO
2018, Residency, University of Missouri, Columbia, MO
Active Research Grants
Principal Investigator, Characterization of canine glioma-associated microglia, (Principal Investigator), CCAH
Co-Investigator, Characterization of metabolic control of glioma stem cell growth kinetics, Ryan Toedebusch (Principal Investigator), CCAH
Co-Principal Investigator, Mechanism of protumorigenic glioma-associated microglia: Characterization of the role of olfactomedin-like 3, Luke Wittenburg (Principal Investigator), UCD Cancer Center
Principal Investigator, CTSC Biorepository Core Resource, (Principal Investigator), VMDO
Research Focus
Neuroimmunology and the role of microglia in canine and feline CNS health and disease, with a specific focus on the role of microglia in primary brain tumorigenesis.
Specialty Focus
Neurology & Neurosurgery
Ten Recent Publications

Toedebusch CM, Bachrach MF, Garcia VB, Johnson GC, Katz ML, Shaw G, Coates JR, Garcia ML
Cerebrospinal fluid levels of phosphorylated neurofilament heavy as a diagnostic marker of canine degenerative myelopathy

Villalon E, Jones MR, Sibigtroth C, Zino SJ, Dale JM, Landayan DS, Shen H, Cornelison DDW, Garcia ML
Muscle spindle alterations precede onset of sensorimotor deficits in Charcot-Marie-Tooth type 2E

Shababi M, Feng Z, Villalon E, Sibigtroth CM, Osman EY, Miller MR, Williams-Simon PA, Lombardi A, Sass TH, Atkinson AK, Garcia ML, Ko CK, Lorson CL
Rescue of a mouse model of spinal muscular atrophy with respiratory distress type 1 by AAV9-IGHMBP2 is dose dependent

Katz ML, Coates JR, Sibigtroth CM, Taylor JC, Carpentier M, Young WM, Wininger FA, Kennedy D, Vuillemenot BR, O’Neill CA
Enzyme replacement therapy attenuates disease progression in a canine model of late-infantile neuronal ceroid lipofuscinosis (CLN2 disease)

Smith SMC, Mitchell GS, Friedle SA, Sibigtroth CM, Vinit S, Watters JJ
Hypoxia attenuates puriergic P2X receptor induced inflammatory gene expression in brainstem microglia