Dori L Borjesson

Dori L Borjesson

Professor

Pathology, Microbiology & Immunology

Office
4325 Vet Med 3A, Davis, CA 95616

Licenses
Diplomate American College of Veterinary Pathology (Clinical Pathology)
Education
1988, BA, The Colorado College, Colorado Springs, CO
1995, MPVM, University of California, Davis, CA
1995, DVM, University of California, Davis, CA
2002, PhD, University of California, Davis, CA
Active Research Grants
Co-Investigator, Xenogeneic Scaffolds for Heart Valve Tissue Engineering, Griffiths (Principal Investigator), NIH (NHBLI), RO1
Principal Investigator, Exploring the mechanisms by which feline mesenchymal stem cells downregulate T cell activation and proliferation, (Principal Investigator), Winn Feline Foundation
Principal Investigator, Deciphering feline stem cell interactions with CD8+ T cells, (Principal Investigator), VIRC Pilot Grant Program
Co-Investigator, Self assembling process in tissue engineering of articular cartilage, Athanasiou (Principal Investigator), NIH, RO1
Co-Principal Investigator, Stem Cell Tracking in the equine distal limb using Positron Emission Tomography, Spriet (Principal Investigator), UC Davis, Center for Equine Health
Principal Investigator, Mesenchymal stem cells for canine inflammatory brain disease, (Principal Investigator), Center for Companion Animal Health (CCAH) and Center for Equine Health (CEH)
Co-Principal Investigator, Mesenchymal Stem Cell Therapy for Gut Mucosal Recovery in the SIV Model of AIDS, Dandekar (Principal Investigator), NIH (NIAIS), R21
Honors and Awards
1988 Graduation with Distinction, The Colorado College
1991 Best research/presentation award for undergraduate thesis research
1994 Hanson-Welles Memorial Scholarship
1995 Phi Zeta Veterinary Honor Society
1997 ASVCP Excellence in Scientific Presentation Award
2001 CL Davis Student Scholarship Award
2014 Zoetis Excellence in Research Award
Most Recent Five Book Chapters
2014 Borjesson DL : Pancreas Cytology, Cowell RL, Tyler RD, Meinkoth JH, De Nicola, (ed), Diagnostic Cytology and Hematology of the Dog and Cat, 2nd Edition, St. Louis, MO. .
2014 Borjesson DL, DeJong KD : Cytologic examination of the urinary tract., Raskin RE, Meyer DJ, (ed), Canine and Feline Cytology, 3rd Edition, Philadelphia, PA. .
2011 Peroni J, and Borjesson DL : Anti-Inflammatory and Immuno-Modulatory Activities of Stem Cells, Stewart A, and Stewart M, (ed), Veterinary Clinics of North America: Equine Practice (Regenerative Medicine), Philadelphia. .
2011 Borjesson DL, Peroni JF : The regenerative medicine laboratory: facilitating stem cell therapy for equine disease, , Clin Lab Med, . 109-23.
2009 Borjesson DL, DeJong KD : Cytologic examination of the urinary tract, Raskin RE and Meyer DJ, (ed), Atlas of Canine and Feline Cytology, Philadelphia PA. .
Research Focus
I have been actively engaged in research on adult-derived mesenchymal stem cells (MSC). We have developed canine, feline and equine models to assess MSC safety and efficacy. My current research expertise is in MSC biology and immunomodulation. We have begun to define the mechanisms by which MSC alter the immune response and interact with cells of the immune system. Our most significant contribution is in the use of naturally occurring large animal models of disease to study cell therapy for inflammatory diseases. Specifically we are focused on naturally occurring inflammatory bowel disease in dogs, chronic gingivostomatitis in cats and spinal cord injury in dogs. With our canine work, we have focused on how MSCs interact with microbes important to GI health.
Specialty Focus
Clinical Pathology
Ten Recent Publications

2017
Arzi B, Clark KC, Sundaram A, Spriet M, Verstraete FJM, Walker NJ, Loscar MR, Fazel N, Murphy WJ, Vapniarsky N, Borjesson DL
Therapeutic Efficacy of Fresh, Allogeneic Mesenchymal Stem Cells for Severe Refractory Feline Chronic Gingivostomatitis

2017
Clark KC, Fierro FA, Ko EM, Walker NJ, Arzi B, Tepper CG, Dahlenburg H, Cicchetto A, Kol A, Marsh L, Murphy WJ, Fazel N, Borjesson DL
Human and feline adipose-derived mesenchymal stem cells have comparable phenotype, immunomodulatory functions, and transcriptome

2016
Oki AT, Huang B, Beyer AR, May LJ, Truchan HK, Walker NJ, Galloway NL, Borjesson DL, Carlyon JA
Anaplasma phagocytophilum APH0032 Is exposed on the cytosolic face of the pathogen-occupied vacuole and co-opts host cell SUMOylation

2016
Clark KC, Kol A, Shahbenderian S, Granick JL, Walker NJ, Borjesson DL
Canine and equine mesenchymal stem cells grown in serum free media have altered immunophenotype

2016
Arzi B, Mills-Ko E, Verstraete FJ, Kol A, Walker NJ, Badgley MR, Fazel N, Murphy WJ, Vapniarsky N, Borjesson DL
Therapeutic efficacy of fresh, autologous mesenchymal stem cells for severe refractory gingivostomatitis in cats

2015
Kol A, Arzi B, Athanasiou KA, Farmer DL, Nolta JA, Rebhun RB, Chen X, Griffiths LG, Verstraete FJ, Murphy CJ, Borjesson DL
Companion animals: Translational scientist's new best friends

2015
McMahill BG, Spriet M, Sisó S, Manzer MD, Mitchell G, McGee J, Garcia TC, Borjesson DL, Sieber-Blum M, Nolta JA, Sturges BK
Feasibility study of canine epidermal neural crest stem cell transplantation in the spinal cords of dogs