Gregory Lanzaro

Gregory Lanzaro

Professor

Pathology, Microbiology & Immunology

Office
4225 VM3B, Davis, CA 95616

Education
1972, BS, Kansas State University, Manhattan, Kansas
1978, MS, University of Arizona, Tucson, Arizona
1986, PhD, University of Florida, Gainesville, Florida
1988, Post-doctoral, Mississippi State University, Starkville, Mississippi
1991, Post-doctoral, University of California, Davis, Davis, California
1995, MacArthur Fellow, National Institutes of Health, Laboratory of Parasitic Diseases, Bethesda, Maryland
Active Research Grants
Co-Principal Investigator, Safely engineering various classes of gene drives to control a major invasive disease vector, Ae. aegypti., Omar Akbari, UCR (Principal Investigator), Defense Advanced Research Projects Agency (DARPA)
Co-Investigator, Pacific Southwest Regional Center Excellence in Vector-Borne Diseases, Christopher Barker, UCD (Principal Investigator), Center for Disease Control
Principal Investigator, Evaluating leading GM mosquito strategies using novel A. gambiae population dynamic data and models, (Principal Investigator), NIH
Co-Principal Investigator, TIGS-UC DAVIS – Field trials for the evaluation of GE Anopheles malaria vectors, Ethan Bier, UCSD (Principal Investigator), The Tata Institute for Active Genetics and Society
Co-Principal Investigator, UC Irvine Malaria Initiative, Anthony James, UCI (Principal Investigator), UC Irvine
Honors and Awards
1991-1995 MacArthur Foundation Fellowship, Molecular Biology of Disease Vectors
2000-2006 Faculty, International Biology of Disease Vectors Course
2002 Chairman, Executive Council, American Committee on Medical Entomology, American Society of Tropical Medicine and Hygiene
2002-2017 Member, External Advisory Panel, Johns Hopkins University Malaria Institute
2005 Rogoff Lectureship, Department of Entomology, Cornell University
2006 Invited guest, White House Malaria Summit
2006 Service Award, Entomological Society of America
2007 Excellence in Research Award, Academic Federation, UC Davis
2007 Plenary Speaker, Annual Meeting, Society of Vector Ecology
2009 Elected Vice-President/President Elect, Society for Vector Ecology
2009 Plenary Speaker, 34th Annual Meeting, Human Biology Association
2009 2009 Student Selected Speaker, Department of Entomology, University of Arkansas
2010 President Elect, Society for Vector Ecology
2010 Plenary Speaker, Keystone Symposia on Molecular and Cell Biology
2010 Keynote Speaker, 10th Annual Symposium, Center for Host-Parasite Interactions, McGill University
2010 Keynote Speaker, 14th Annual Arthromint Meeting, Oswaldo Cruz Institute, Ilha Grande, Brazil
2010 Invited Speaker, Biology of Mosquito Vectors Symposium, Johns Hopkins University
2010 2010 Editor's Choice Award by the Entomological Society of America
2011 President, Society for Vector Ecology
2013 Delegate, Albert Schweitzer Centennial, Libreville, Gabon, Central Africa
2013 Distinguished Service Award, Society for Vector Ecology
2014 Award of Honour/Plenary Speaker, presented by Association of Entomologists, Department of Zoology and Environmental Sciences, Punjabi University
2017 Distinguished Service Award, Society for Vector Ecology
2019 Exemplary Service Recognition, Society of Vector Ecology
Most Recent Five Book Chapters
2013 Lanzaro GC, Lee Y : Chapter 6. Speciation in Anopheles gambiae - The distribution of genetic polymorphism and patterns of reproductive isolation among natural populations, Manguin S, (ed), Anopheles mosquitoes - New insights into malaria vectors, . 173-96.
2011 Dorn P, Noireau F, Krafsur ES, Lanzaro GC, Cornel AJ : Chapter 18: Genetics of major insect vectors, Tibayrenc M, (ed), Genetics and Evolution of Infectious Disease, London / Burlington, MA. .
2005 Lanzaro GC, Nuzhdin S, Tripet F : Tools for monitoring the genetic structure and stability of mosquito populations, , In: Proceedings: Working Group on Strategic Plan to Bridge Laboratory and Field Research In Disease Vector Control 14-16 July 2004, ICIPE, Nairobi, Kenya, The Netherlands. .
2003 Lanzaro, GC, Tripet, F : Gene flow among populations of Anopheles gambiae: A critical review, Takken, W, Scott, TW, (ed), Ecological Aspects for the Application of Genetically Modified Mosquitoes, Wageningen, The Netherlands. 109-132.
Research Focus
Vector biology, population genetics. My overall research interest is in the population genetics of insect vectors of human and animal diseases. I have developed a program that pursues knowledge that may be applied to the control of vectorborne diseases but at the same time addresses critical issues in basic evolutionary genetics. My work has transitioned from classical population genetics to a more contemporary population genomics approach. Whereas the earlier work was based on analyses using genic markers, such as microsatellite DNA and single nucleotide polymorphisms, our current work applies next generation sequencing to study individual insect genomes, allowing us to explore problems with far greater depth and to address questions that were intractable just a few years ago. In parallel with our increasing use of genomics I have established a program in bioinformatics which is essential for both the management and analysis of the large body of data we are generating using next generation sequencing. I am pursuing this interest within the context of four major avenues of research: 1) Population genetics of the human malaria vector, Anopheles gambiae in west and central Africa: This work deals with describing the genetic structure of populations, understanding the forces responsible for this structure and how patterns of gene flow influence the distribution of traits critical to understanding and managing malaria transmission. I have been working at field sites in Africa since 1991 and my current program has been supported continuously since 1996 with support in the form of a series of R01 grants from NIH on which I serve as P.I. 2) Genome-wide association mapping (GWAS) in the mosquito Anopheles arabiensis, the most important malaria vector in east Africa: Our focus is to understand the genetic basis of two critically import behavioral phenotypes in this mosquito: host preference (animal vs human blood feeding) and adult resting behavior (indoor vs outdoor). This project is funded by NIH with me as the PI and in collaboration with the Ifakara Health Institute in Tanzania. 3) Interactions between the South American vector, Anopheles darlingi and the human malaria parasite Plasmodium vivax. We are using a genomics approach to identify innate immune pathway related genes that are associated with the mosquito's ability kill the malaria parasite in the mosquito before it becomes infective to man. This project is being funded by the Brazilian government through a program called Brazil Science without Borders and conducted in collaboration with the Oswaldo Cruz Institute in Belo Horizonte, Brazil and the National Institute of Amazon Research, Manaus, Brazil
Specialty Focus
Entomology, population genetics, genomics
Ten Recent Publications

2019
Lee Y, Schmidt H, Collier TC, Conner WR, Hanemaaijer MJ, Slatkin M, Marshall JM, Chiu JC, Smartt CT, Lanzaro GC, Mulligan FS, Cornel AJ
Genome-wide divergence among invasive populations of Aedes aegypti in California.

2019
Loiseau C, Melo M, Lee Y, Pereira H, Hanemaaijer MJ, Lanzaro GC, Cornel AJ, Didham R, Gilbert F
High endemism of mosquitoes on São Tomé and Príncipe Islands: evaluating the general dynamic model in a worldwide island comparison

2018
Hanemaaijer MJ, Collier TC, Chang A, Shott CC, Houston PD, Schmidt H, Main BJ, Cornel AJ, Lee Y, Lanzaro GC
The fate of genes that cross species boundaries after a major hybridization event in a natural mosquito population

2016
Main BJ, Lee Y, Ferguson HM, Kreppel KS, Kihonda A, Govella NJ, Collier TC, Cornel AJ, Eskin E, Kang EY, Nieman CC, Weakley AM and Lanzaro GC
The Genetic Basis of Host Preference and Resting Behavior in the Major African Malaria Vector, Anopheles arabiensis.

2016
Cornel AJ, Brisco KK, Tadei WP, Secundino NF, Rafael MS, Galardo AK, Medeiros JF, Pessoa FA, Ríos-Velásquez CM, Lee Y, Pimenta PF, Lanzaro GC
Anopheles darlingi polytene chromosomes: revised maps including newly described inversions and evidence for population structure in Manaus.