Hannah Savage

Hannah Savage

Assistant Professor

Pathology, Microbiology & Immunology


Licenses
American College of Veterinary Microbiologists, Diplomate
USDA APHIS, Accreditation #088914, Category II
CA Veterinary Medical Board, License #VET23516
Education
2019, DVM, University of California, Davis, Davis, CA, USA
2018, Ph.D., University of California, Davis, Davis, CA, USA
Active Research Grants
Principal Investigator, Establishment of flow cytometry protocol to investigate prognostic markers in canine cancer, (Principal Investigator), CCAH
Honors and Awards
2012-2013 NIH-YEAR Program Award, UC Davis School of Veterinary Medicine
2013-2014 UC Davis Graduate Scholars Fellowship, Office of Graduate Studies
2014 AAI Young Investigator and Travel Award, Merinoff B-1 Cell World Conference, Tarrytown Estate House, Tarrytown, New York
2017 CCM Student Research Scholarship Award, UC Davis Center for Comparative Medicine (awarded to best first-author graduate student publication of the year)
2017 Dr. Jacob Traum Endowed Scholarship, UC Davis SVM
2018 Donna J. Waldrop-Walker Scholarship, UC Davis SVM
2019 Class of 1984 Endowed Scholarship, UC Davis SVM
2020-2022 Tri-Institutional Partnership on Microbiome Research
Research Focus
Host-microbe interactions, particularly interactions between the host and the microbiota in the gastrointestinal tract and how the host contributes to colonization resistance
Ten Recent Publications

2024
Brostoff T, Savage HP, Jackson KA, Dutra JC, Fontaine JH, Hartigan-O’Connor DJ, Carney RP, Pesavento PA
Feline Infectious Peritonitis mRNA Vaccine Elicits Both Humoral and Cellular Immune Responses in Mice

2024
Lee J-Y, Bays DJ, Savage HP, Bäumler AJ
The human gut microbiome in health and disease: time for a new chapter?

2024
Savage HP, Bays DJ, Tiffany CR, Gonzalez MAF, Bejarano EJ, Carvalho TP, Luo Z, Masson HLP, Nguyen H, Santos RL, Reagan KL, Thompson GR, Bäumler AJ
Epithelial hypoxia maintains colonization resistance against Candida albicans

2023
English BC, Savage HP, Mahan SP, Diaz-Ochoa VE, Young BM, Abuaita BH, Sule G, Knight JS, O'Riordan MX, Bäumler AJ, Tsolis RM
The IRE1a-XBP1 Signaling Axis Promotes Glycolytic Reprogramming in Response to Inflammatory Stimuli

2023
Smith FL, Savage HP, Luo Z, Tipton CM, Lee FE, Apostol AC, Beaudin AE, Lopez DA, Jensen I, Keller S, Baumgarth N
B-1 plasma cells require non-cognate CD4 T cell help to generate a unique repertoire of natural IgM

2022
Liou MJ, Miller BM, Litvak Y, Nguyen H, Natwick DE, Savage HP, Rixon JA, Mahan SP, Hiyoshi H, Rogers AWL, Velazquez EM, Butler BP, Collins SR, McSorley SJ, Harshey RM, Byndloss MX, Simon SI, Bäumler AJ
Host cells subdivide nutrient niches into discrete biogeographical microhabitats for gut microbes

2021
Cevallos SA, Lee JY, Velazquez EM, Foegeding NJ, Shelton CD, Tiffany CR, Parry BH, Stull-Lane AR, Olsan EE, Savage HP, Nguyen H, Ghanaat SS, Byndloss AJ, Agu IO, Tsolis RM, Byndloss MX, Bäumler AJ
5-Aminosalicylic Acid Ameliorates Colitis and Checks Dysbiotic Escherichia coli Expansion by Activating PPAR-? Signaling in the Intestinal Epithelium

2019
Kreuk LS, Koch MA, Slayden LC, Lind NA, Chu S, Savage HP, Kantor AB, Baumgarth N, Barton GM
B cell receptor and Toll-like receptor signaling coordinate to control distinct B-1 responses to both self and the microbiota

2019
Savage HP, Kläsener K, Smith FL, Luo Z, Reth M, Baumgarth N
TLR induces reorganization of the IgM-BCR complex regulating murine B-1 cell responses to infections

2018
Ordoñez C, Savage HP, Tarajia M, Rivera R, Weeks-Galindo C, Sambrano D, Riley L, Fernandez PL, Baumgarth N, Goodridge A
Both B-1a and B-1b cells exposed to Mycobacterium tuberculosis lipids differentiate into IgM antibody-secreting cells