Helen Raybould

Professor Emeritus

Anatomy, Physiology & Cell Biology

2021 Vet Med 3B, Davis, CA 95616

1977, BS, University of Birmingham, UK,
1986, PhD, University of Liverpool, UK,
Active Research Grants
Principal Investigator, Cholecystokinin: role in postprandial gastric motility, (Principal Investigator), NIH DDK
Principal Investigator, Activation of probiotic bacteria by milk glycans, (Principal Investigator), NIH NCCIH
Principal Investigator, UC Davis Mouse Metabolic Phenotyping Center: Microbiome Research Project , (Principal Investigator), NIH DDK
Other, UC Davis Mouse Metabolic Phenotyping Center: Core D, Lloyd (Principal Investigator), NIHDDK
Co-Investigator, Mapping of the Neuroimmune Interface, Reardon (Principal Investigator), NIH
Co-Investigator, Multispecies comparison of the impact of obesity on GVHD/GVT, Murphy (Principal Investigator), NIHNCI
Co-Principal Investigator, A microfabricated model of enteric epithelium-neuron interaction for identification of effector compounds in the gut microbiota., Seker, Raybould, Marco (Principal Investigator), UC Davis Microbiome Special Research Program: Seed Funding Program
Co-Principal Investigator, 2nd generation HMO: Beyond Infant Nutrition, Barile, Mills, Raybould (Principal Investigator), BASF
Co-Investigator, The role of leptin receptor glycosylation in peptin resistance and obesity, Barboza (Principal Investigator), NIHDDK
Co-Principal Investigator, Whey phospholipid concentrate as a source of bioactive compounds in human health, Barile, Mills, Raybould, Taha (Principal Investigator), National Dairy Council
Most Recent Five Book Chapters
2019 De Lartigue, G and Raybould, HE: The Gastrointestinal Tract and Control of Food Intake, Johnson, (ed), Physiology of The Gastrointestinal Tract, Vol. 2(5), , , . .
2017 Barrett K, Raybould HE: Section VI: Gastrointestinal physiology, Koeppen BM, Stanton BA, (ed), Berne & Levy Physiology 7th edition, . .
2012 De Lartigue G, Raybould HE: The Gastrointestinal Tract and Control of Food Intake, Johnson, (ed), Physiology of The Gastrointestinal Tract, . 1963-1078.
2009 Pandol SJ, Raybould HE, Yee HF: Integrative responses of the gastrointestinal tract and liver to a meal, Yamada T, (ed), Textbook of Gastroenterology, Oxford, UK. .
2008 Barrett K, Raybould HE: Section VI: Gastrointestinal physiology, Koeppen BM, Stanton BA, (ed), Berne and Levy Physiology 6th edition, . .
Research Focus
I am an intergrative physiologist with training in neurophysiology and gastrointestinal physiology. My research focuses on understanding the mechanisms by which gut luminal contents are sensed by chemosensing cells in the epithelium and activation of the vagal afferent (gut-brain) pathway. The research focuses on how both nutrients and bacterially-derived factors activate gut endocrine cells and how this information is transmitted to the brain to alter GI function and food intake. We study how these pathways are altered in metabolic disease, including obesity and type 2 diabetes. The research focuses on alterations in the gut microbiota and intestinal permeability in obesity, and how these factors may drive changes in the gut-brain pathway. We also work on the beneficial effects of prebiotic milk oligosaccharides and prebiotic bacteria in metabolic disease.
Ten Recent Publications

Kim K, Ehrlich A, Perng V, Chase J, Raybould H, Li X, Atwill ER, Whelan R, Sokale A, Liu Y
Algae-derived ß-glucan enhanced gut health and immune responses of weaned pigs experimentally infected with a pathogenic E. coli

Garas LC, Hamilton MK, Dawson MW, Wang JL, Murray JD, Raybould HE, Maga EA
Lysozyme-rich milk mitigates effects of malnutrition in a pig model of malnutrition and infection

Guerville M, Hamilton MK, Ronveaux CC, Ellero-Simatos S, Raybould HE, Boudry G
Chronic refined low-fat diet consumption reduces cholecystokinin satiation in rats

Langhans W, Adan R, Arnold M, Banks WA, Card JP, Dailey MJ, Daniels D, de Kloet AD, de Lartigue G, Dickson S, Fedele S, Grill HJ, Jansson JO, Kaufman S, Kolar G, Krause E, Lee SJ, Le Foll C, Levin BE, Lutz TA, Mansouri A, Moran TH, Pacheco-López G, Ramachandran D, Raybould H, Rinaman L, Samson WK, Sanchez-Watts G, Seeley RJ, Skibicka KP, Small D, Spector AC, Tamashiro KL, Templeton B, Trapp S, Tso P, Watts AG, Weissfeld N, Williams D, Wolfrum C, Yosten G, Woods SC
New horizons for future research - Critical issues to consider for maximizing research excellence and impact

Boudry G, Hamilton MK, Chichlowski M, Wickramasinghe S, Barile D, Kalanetra KM, Mills DA, Raybould HE^
Bovine milk oligosaccharides decrease gut permeability and improve inflammation and microbial dysbiosis in diet-induced obese mice

Ilkiw JE, Nelson RW, Watson JL, Conley AJ, Raybould HE, Chigerwe M, Boudreaux K
Curricular Revision and Reform: The Process, What Was Important, and Lessons Learned

Park D, Xu G, Barboza M, Shah IM, Wong M, Raybould H, Mills DA, Lebrilla CB
Enterocyte glycosylation is responsive to changes in extracellular conditions: implications for membrane functions