Jennifer Rutkowsky

Jennifer Rutkowsky

Assistant Project Scientist

Molecular Biosciences


Active Research Grants
Co-Investigator, Mouse Metabolic Phenotyping Center, Lloyd (Principal Investigator), NIH
Principal Investigator, Effect of isocaloric restriction on high fat diet induced cognitive impairment , (Principal Investigator), NIDDK
Co-Investigator, A ketogenic longevity diet for resistance to age-related functional decline and alzheimer's disease, Cortopassi (Principal Investigator), NIH:NIA
Co-Investigator, Behavioral assay development to assess preference for exercise relative to palatable food , John Rutledge (Principal Investigator), NIH National Institute of Diabetes, Digestive & Kidney Diseases (NIDDK)
Co-Investigator, Home cage indirect respiration calorimeter, home cage good intake analyzer, bomb calorimeter, and NMR body composition analyzer for the assessment of murine energy balance. , Jon J. Ramsey (Principal Investigator),
Honors and Awards
2015 Richard C. Woodard Memorial Endowed Fund Award, UCDMC Department of Internal Medicine-Outstanding Manuscript in Metabolic Diseases Research
2012 Richard A. and Nora Eccles Harrison Award in Diabetes Research
2009 Graduate Student Association Travel Award
2009 Winter Cell and Developmental Biology Work-study Research Assistantship Award
2008 Fall Cell and Developmental Biology Work-study Research Assistantship Award
2008 Winter Cell and Developmental Biology Work-study Research Assistantship Award
Research Focus
Diet influnce on aging, metabolism, neurophysiology, and cognitive function.
Specialty Focus
Cognitive function(memory), neuroinflammation, and gliophysiology.
Ten Recent Publications

2018
Vogel Ciernia A, Yasui DH, Pride MC, Durbin-Johnson B, Noronha AB, Chang A, Knotts TA, Rutkowsky JR, Ramsey JJ, Crawley JN, LaSalle JM
MeCP2 isoform e1 mutant mice recapitulate motor and metabolic phenotypes of Rett syndrome

2018
Norman JE, Rutkowsky J, Bodine S, Rutledge JC
The potential mechanisms of exercise-induced cognitive protection: A literature review

2018
Rutkowsky JM, Lee LL, Puchowicz M, Golub MS, Befroy DE, Wilson DW, Anderson S, Cline G, Bini J, Borkowski K, Knotts TA, Rutledge JC
Reduced cognitive function, increased blood-brain-barrier transport and inflammatory responses, and altered brain metabolites in LDLr -/-and C57BL/6 mice fed a western diet

2018
Yokoyama AS, Dunaway K, Rutkowsky J, Rutledge JC, Milenkovic D
Chronic consumption of a western diet modifies the DNA methylation profile in the frontal cortex of mice

2017
Ono-Moore KD, Zhao L, Huang S, Kim J, Rutkowsky JM, Snodgrass RG, Schneider DA, Quon MJ, Graham JL, Havel PJ, Hwang DH
Transgenic mice with ectopic expression of constitutively active TLR4 in adipose tissues do not show impaired insulin sensitivity

2017
Lee LL, Aung HH, Wilson DW, Anderson SE, Rutledge JC, Rutkowsky JM^
Triglyceride-rich lipoprotein lipolysis products increase blood-brain barrier transfer coefficient and induce astrocyte lipid droplets and cell stress

2014
Rutkowsky JM, Knotts TA, Ono-Moore KD, McCoin CS, Huang S, Schneider D, Singh S, Adams SH, Hwang DH
Acylcarnitines activate proinflammatory signaling pathways.

2012
Huang S, Rutkowsky JM, Snodgrass RG, Ono-Moore KD, Schneider DA, Newman JW, Adams SH, Hwang DH
Saturated fatty acids activate TLR-mediated proinflammatory signaling pathways.

2011
Rutkowsky JM, Wallace BK, Wise PM, O'Donnell ME
Effects of estradiol on ischemic factor-induced astrocyte swelling and AQP4 protein abundance.

2008
Brillault J, Lam TI, Rutkowsky JM, Foroutan S, O'Donnell ME
Hypoxia effects on cell volume and ion uptake of cerebral microvascular endothelial cells.