Jeroen Saeij

Jeroen Saeij

Associate Professor

Pathology, Microbiology & Immunology

3325 VM3A, Davis, CA 95616

1995, B.Sc., Wageningen University, Wageningen, The Netherlands
1997, M.Sc., Wageningen University, Wageningen, The Netherlands
2002, Ph.D., Wageningen University, Wageningen, The Netherlands
Active Research Grants
Principal Investigator, Toxoplasma proteins that modulate the host cell, (Principal Investigator), National Institutes of Health
Principal Investigator, Characterization of Sarcocystis neurona secreted proteins that could function as vaccine candidates to protect horses against the neurological disease Equine protozoal myeloencephalitis , (Principal Investigator), Center for Equine Health
Principal Investigator, Discovering essential Toxoplasma Sporozoite Genes: Production of uninfective oocysts, (Principal Investigator), Center for Companion Animal Health
Trainer, Modulation of the human immune response by the heart parasite Toxoplasma gondii, Debanjan Mukhopadhyay (Principal Investigator), American Heart Association
Trainer, Identification and characterization of Toxoplasma genes that determine fitness in interferon gamma-stimulated human cells, Shruthi Krishnamurthi (Principal Investigator), American Heart Association
Principal Investigator, Regulatory factors that determine Toxoplasma bradyzoite to merozoites conversion , (Principal Investigator), National Institutes of Health
Honors and Awards
1995 B.S. cum laude, Wageningen University, The Netherlands
1996 ERASMUS fellowship, European Union, Santiago de Compostela, Spain
1997 M.S. cum laude, Wageningen University, The Netherlands
2002 Ph.D. cum laude, Wageningen University
2003 Best publication award, Wageningen Institute of Animal Sciences
2003-2005 Postdoctoral fellowship, California University-wide AIDS Research Program
2005 Oral presentation award, Molecular Parasitology Meeting
2008 John Reed Fund Award, MIT
2008 Massachusetts Life Sciences Center New Investigator Award
2010 Pew Scholar in the Biomedical Sciences Award
2012-2013 Swanson Career Development Professorship in the Life Sciences, MIT
2013 Selected American Society for Microbiology division AA (Free-Living, Symbiotic and Parasitic Protists) Lecturer, annual ASM meeting, Denver
Most Recent Five Book Chapters
2002 Verburg-van Kemenade BML, Engelsma MY, Huising MO, Kwang J, van Muiswinkel WB, Saeij JP, Metz JR, Flik G : Crosstalk between the neuro-endocrine and immune system in teleosts, Goos HJ Th [and others], (ed), Perspective in Comparative Endocrinology: Unity and Diversity, Bologna, Italy. 359-67.
Specialty Focus
Genetics, Genomics, Parasitology, Immunology, Biochemistry, Bioinformatics, Molecular Biology, Human Disease, Animal Disease.
Ten Recent Publications

Wang Y, Cirelli KM, Barros PDC, Sangaré LO, Butty V, Hassan MA, Pesavento P, Mete A, Saeij JP^
Three Toxoplasma gondii Dense Granule Proteins Are Required for Induction of Lewis Rat Macrophage Pyroptosis

Arranz-Solís D, Regidor-Cerrillo J, Lourido S, Ortega-Mora LM, Saeij JP^
Toxoplasma CRISPR/Cas9 constructs are functional for gene disruption in Neospora caninum

Krishnamurthy S, Konstantinou EK, Young LH, Gold DA, Saeij JP^
The human immune response to Toxoplasma: Autophagy versus cell death

Sidik SM, Huet D, Ganesan SM, Huynh MH, Wang T, Nasamu AS, Thiru P, Saeij JP, Carruthers VB, Niles JC, Lourido S
A Genome-wide CRISPR screen in Toxoplasma identifies essential apicomplexan genes

Fink A, Hassan MA, Okan NA, Sheffer M, Camejo A, Saeij JP, Kasper DL
Early interactions of murine macrophages with Francisella tularensis map to mouse chromosome 19

Lorenzi H, Khan A, Behnke MS, Namasivayam S, Swapna LS, Hadjithomas M, Karamycheva S, Pinney D, Brunk BP, Ajioka JW, Ajzenberg D, Boothroyd JC, Boyle JP, Dardé ML, Diaz-Miranda MA, Dubey JP, Fritz HM, Gennari SM, Gregory BD, Kim K, Saeij JP, Su C, White MW, Zhu XQ, Howe DK, Rosenthal BM, Grigg ME, Parkinson J, Liu L, Kissinger JC, Roos DS, Sibley LD
Local admixture of amplified and diversified secreted pathogenesis determinants shapes mosaic Toxoplasma gondii genomes