Lark L A Coffey

Lark L A Coffey

Associate Professor

Pathology, Microbiology & Immunology

Office
1 Shields Ave, Davis, CA 95616

Licenses
UC Davis Biomedical and Engineering Entrepreneurship Academy Graduate
Education
2000, B.S., University of the South, Sewanee, Tennessee
2005, Ph.D., University of Texas Medical Branch, Galveston, Texas
2011, , Institut Pasteur, Paris, France
2013, , Blood Systems Research Institute/University of California San Francisco, California, San Francisco, California
2018, , University of California, Davis, Davis, California
Active Research Grants
Principal Investigator, Engineering high fidelity mutations to increase safety of live-attenuated alphavirus vaccines , (Principal Investigator), NIH NIAID
Co-Investigator, Characterization of blood transfusion-transmission of Zika virus in macaques, Mike Busch, Blood Systems Research Institute/UCSF (Principal Investigator), NIH NHLBI extension of Recipient Epidemiology and Donor Evaluation Study-III
Co-Investigator, Macaque model of Zika virus infection, Koen Van Rompay (Principal Investigator), NIH NIAID
Co-Investigator, Pacific Southwest Regional Center of Excellence for Vector-Borne Disease Research at the University of California, Chris Barker, PMI, William Walton, UC Riverside (Principal Investigator), Centers for Disease Control Regional Centers of Excellence
Co-Principal Investigator, Chikungunya virus like particle vaccine development: non-human primate studies to establish correlates of protection, Koen Van Rompay, California National Primate Research Center (Principal Investigator), FDA via PaxVax, Inc.
Co-Investigator, Cognitive, affective, and social development following fetal Zika virus infection of rhesus macaques. Percentile: 4, Eliza-Bliss Moreau, UC Davis (Principal Investigator), NIH NICHD
Principal Investigator, Viral molecular determinants of pathogenic mosquito-borne virus emergence: Usutu virus in Europe and St. Louis encephalitis virus in California, (Principal Investigator), Zoetis UCD2
Principal Investigator, Influenza A virus surveillance in avians and marine mammals in California, (Principal Investigator), NIH NIAID Center for Excellence in Influenza Virus Research
Honors and Awards
2002 Bodhan Nechay Academic Scholarship;
University of Texas Medical Branch, Galveston, TX
2005 Zhou Sisters Academic Scholarship, University of Texas Medical Branch, Galveston, TX
2005-2008 Philippe Foundation International Scholar, Institut Pasteur, Paris, France
2007-2009 Sigma Xi Scientific Honor Society
Most Recent Five Book Chapters
2016 Coffey L : The Nature of Viruses, MacLachlan, NJ, Dubai, EJ, (ed), Fenner’s Veterinary Virology, London. 13-16.
2016 Coffey LL, Weaver SC, Forrester N : Alphavirus Evolution, , Alphaviruses: Molecular Biology, Pathogenesis and Host Interactions, . 21-26.
2016 Forrester NL, Gutierrez S, Coffey LL : The Evolution and Transmission of Vector-Borne Viruses, Weaver, Denison, Roossinck, Vignuzzi, (ed), Virus Evolution: Current Research and Future Directions, . 61-100.
2015 Tsetsarkin K, Coffey LL, Weaver SC : Interaction of Chikungunya virus with the mosquito vector, , Chikungunya Virus, . 99-126.
2008 Coffey LL : Togaviruses not associated with human disease, Mahy B, Van Regenmortel M, (ed), Encyclopedia of Virology, 3rd Edition, Oxford. 91-6.
Research Focus
Mosquito-borne virus ecology, evolution and emergenceMy research seeks to understand patterns of viral molecular evolution and the viral genetic factors that promote mosquito-borne virus emergence and disease.
Specialty Focus
Genetics of mosquito-borne virusesTransmission dynamics of mosquito-borne virusesSurveillance of mosquito-borne virusesAlphaviruses, flavivirusesRNA virus evolution
Ten Recent Publications

2019
Grubaugh ND, Gangavarapu K, Quick J, Matteson NL, Goes De Jesus J, Main BJ, Tan AL, Paul LM, Brackney DE, Grewal S, Gurfield N, Van Rompay KKA, Isern S, Micahel SF, Coffey LL, Loman NJ, Andersen KG.
An amplicon-based sequencing framework for accurately measuring intrahost virus diversity using PrimalSeq and iVar

2018
Keeffe JR, Van Rompay KKA, Olsen P, Wang Q Gazumyan A, Azzopardi SA, Schaefer-Babajew D, Lee YE, Stuart JB, Singapuri A, Watanabe J, Usachenko J, Ardeshir A, Saeed M, Agudelo M, Eisenreich T, Bournazos S, Oliveira TY, Rice CM, Coffey LL, MacDonald MM, Bjorkman PJ, Nussenzweig MC, Robbiani, DF
A Combination of Two Human Monoclonal Antibodies Prevents Zika Virus Escape Mutations in Non-human Primates

2018
Sadeghi M, Altan E, Deng X, Barker C , Fang Y, Coffey LL, Delwart E
Virome of ~20,000 Culex mosquitoes collected throughout California

2018
Dudley DM, Van Rompay KK , Coffey LL, Ardeshir A, Keesler RI, Bliss-Moreau E, Grigsby PL, Steinbach RJ, Hirsch AJ, MacAllister RP, Pecoraro HL, Colgin LM, Hodge T, Streblow DN, Tardif S, Patterson JL, Tamhankar M, Seferovic M, Aagaard KM, Sánchez-San Martín C, Chiu CY, Panganiban AT, Veazey RS, Wang X, Maness NJ, Gilbert MH, Bohm RP, Adams Waldorf KM, Gale Jr. M, Rajagopal L, Hotchkiss CE, Mohr EL, Capuano III SV, Simmons HA, Mejia A, Friedrich TC, Golos TG, O’Connor DH
Miscarriage and stillbirth following maternal Zika virus infection in nonhuman primates

2018
Main BJ, Nicholson J, Winokur OC, Steiner C, Riemersma KK, Stuart J, Takeshita R, Krasnec M, Barker CM, Coffey LL
Vector competence of Aedes aegypti, Culex tarsalis, and Culex quinquefasciatus from California for Zika virus

2018
Coffey LL, Keesler RI, Pesavento PP, Woolard K, Singapuri A, Watanabe J, Cruzen C, Christe KL, Usachenko JU, Yee J, Heng VA, Bliss-Moreau E, Reader JR, von Morgenland W, Gibbons AM, Jackson K, Ardeshir A, Heimsath H, Permar SR, Senthamaraikannan P, Presicce P, Kallapur SG, Linnen JM, Gao K, Orr R, MacGill T, McClure M, McFarland R, Morrison JM, Van Rompay KKA.
Intraamniotic Zika virus inoculation of pregnant rhesus macaques produces fetal neurologic disease

2018
Prow NA, Mah MG, Deerain JM, Warrilow D, Colmant AMG, O'Brien CA, Harrison JJ, McLean BJ, Hewlett EK, Piyasena TBH, Hall-Mendelin S, van den Hurk AF, Watterson D, Huang B, Schulz BL, Webb CE, Johansen CA, Chow WK, Hobson-Peters J, Cazier C, Coffey LL, Faddy HM, Suhrbier A, Bielefeldt-Ohmann H, Hall RA
New genotypes of Liao ning virus (LNV) in Australia exhibit an insect-specific phenotype