Lark L Coffey

Lark L Coffey

Professor

Pathology, Microbiology & Immunology

Office
1 Shields Ave, Davis, CA 95616

Licenses
UC Davis Biomedical and Engineering Entrepreneurship Academy Graduate
Education
2000, B.S., University of the South, Sewanee, Tennessee
2005, Ph.D., University of Texas Medical Branch, Galveston, Texas
2006, post-doctoral fellowship, Institut Pasteur, Paris, France
2011, post-doctoral fellowship, Blood Systems Research Institute/University of California San Francisco, California, San Francisco, California
2013, Assistant Professor, University of California, Davis, Davis, California
Active Research Grants
Co-Investigator, Innate Immune Responses to SARS-CoV-2 in Alzheimer's Disease mouse models, Qizhi Gong (Principal Investigator), NIH / NIDCD
Co-Investigator, Molecular mechanisms linking viral replication and neuropathogenesis, Priya Shah (Principal Investigator), NIH / NIAID
Co-Investigator, Development of a Rhesus macaque (Macaca mulatta) model to test vaccines and treatments against Mayaro virus, a virus with epidemic potential, Shannan Rossi (Principal Investigator), California National Primate Research Center
Principal Investigator, Evaluating metagenomic arbovirus detection using nanopore sequencing: a field-forward sequencing approach, (Principal Investigator), Coachella Valley Mosquito and Vector Control District
Co-Investigator, In vivo functional risk assessment of patient-specific genetic variants for severe COVID-19, Kent Lloyd (Principal Investigator), NIH / Office of the Director
Co-Investigator, Innate immune responses to SARS-CoV-2 infection in the mouse olfactory epithelium, Qizhi Gong (Principal Investigator), NIH/NIDCD
Co-Investigator, Impacts of rapid landscape change and biodiversity on virus host specificity, Christine Kreuder Johnson (Principal Investigator), NSF/ Ecology and Evolution of Infectious Diseases
Co-Investigator, Enhancement of existing ABSL3 facilities to accommodate expanded mouse validation and phenotyping., Kent Lloyd (Principal Investigator), NIH / Office of Research Infrastructure Programs
Co-Investigator, Assessment of infectivity, pathogenesis, and post-infection sequela of COVID-19 (PASC) in polygenic humanized mouse models of COVID-19, Kent Lloyd (Principal Investigator), NIH / Office of the Director
Co-Investigator, Dual Anti-inflammatory and Anti-viral Strategy to Combat COVID19, Dominik Haudenschild (Principal Investigator), US Department of Defense Congressionally Directed Medical Research Program
Co-Principal Investigator, EpiCenter for Emerging Infectious Disease Intelligence, Christine Kreuder Johnson, Lark Coffey (Principal Investigator), NIH/NIAID
Co-Investigator, Efficacy of bivalent Zika virus-yellow fever vaccine, Koen Van Rompay (Principal Investigator), Access to Advanced Health Institute (AAHI)
External Links
Lab Website
Honors and Awards
2022 Fellow of the American Society of Tropical Medicine and Hygiene
2021 UC Davis Chancellor’s Fellow, recognition for outstanding work in academia
2005-2008 Philippe Foundation International Scholar, Institut Pasteur, Paris, France
2007-2009 Sigma Xi Scientific Honor Society
2005 Zhou Sisters Academic Scholarship, University of Texas Medical Branch, Galveston, TX
2002 Bodhan Nechay Academic Scholarship;
University of Texas Medical Branch, Galveston, TX
Most Recent Five Book Chapters
2021 Reisen WK, Coffey LL, Swetnam DM, Brault, AC: Saint Louis Encephalitis Virus (Flaviviridae), Bamford DH, Zuckerman M, (ed), Encyclopedia of Virology, Oxford. 805-813.
2016 Coffey LL: The Nature of Viruses, MacLachlan, NJ, Dubai, EJ, (ed), Fenner’s Veterinary Virology, London. 13-16.
2016 Coffey LL, Weaver SC, Forrester N: Alphavirus Evolution, , Alphaviruses: Molecular Biology, Pathogenesis and Host Interactions, . 21-26.
2016 Forrester NL, Gutierrez S, Coffey LL: The Evolution and Transmission of Vector-Borne Viruses, Weaver, Denison, Roossinck, Vignuzzi, (ed), Virus Evolution: Current Research and Future Directions, . 61-100.
2015 Tsetsarkin K, Coffey LL, Weaver SC: Interaction of Chikungunya virus with the mosquito vector, , Chikungunya Virus, . 99-126.
Research Focus
Mosquito-borne virus transmission dynamics, evolution, and emergence Viral genetic mechanisms of emergence focusing on modified virus-host interactions, with a goal of interrupting transmission to reduce human and animal disease.
Specialty Focus

Transmission dynamics and genetics of mosquito-borne alpha- and flaviviruses, RNA virus evolution, SARS-CoV-2 small animal models and countermeasure testing.

Ten Recent Publications

2023
Ball EE, Bennett J, Keesler RI, Van Rompay KKA, Coffey LL^, Bliss-Moreau E
Prenatal Zika virus exposure is associated with lateral geniculate nucleus abnormalities in juvenile rhesus macaques

2023
Weiss CM, Liu H, Ball EE, Hoover AR, Wong TS, Wong CF, Lam S, Hode T, Keel MK, Levenson RM, Chen WR, Coffey LL^
N-dihydrogalactochitosan reduces mortality in a lethal mouse model of SARS-CoV-2

2023
Haudenschild AK, Christiansen BA, Orr S, Ball EE, Weiss CM, Liu H, Fyhrie DP, Yik JHN, Coffey LL, Haudenschild DR
Acute bone loss following SARS-CoV-2 infection in mice

2023
Plancarte M, Kovalenko G, Baldassano J, Ramírez AL, Carrillo S, Duignan PJ, Goodfellow I, Bortz E, Dutta J, van Bakel H, Coffey LL^
Human influenza A virus H1N1 in marine mammals in California, 2019

2023
Van Rompay KKA, Coffey LL, Yee JA, Singapore A, Stuart J, Lanteri MC, Santa Maria F, Lu K, Singh I, Bakkour S, Stone M, Williamson PC, Muench MO, Busch MP, Simmons G
Plasma transfusion-transmission of Zika virus in mice and macaques

2023
Ball EE, Weiss CM, Liu H, Jackson K, Keel MK, Miller CJ, Van Rompay KKA, Coffey LL^, Pesavento PA
Severe Acute Respiratory Syndrome Coronavirus 2 Vasculopathy in a Syrian Golden Hamster Model

2023
Evans TS, Tan CW, Aung O, Phyu S, Lin H, Coffey LL, Toe AT, Aung P, Aung TH, Aung NT, Weiss CM, Thant KZ, Htun ZT, Murray S, Wang L, Johnson CK, Thu HM
Exposure to diverse sarbecoviruses indicates frequent zoonotic spillover in human communities interacting with wildlife

2022
Van Rompay KKA, Olstad KJ, Sammak RL, Dutra J, Watanabe JK, Usachenko JL, Immareddy R, Roh JW, Verma A, Shaan Lakshmanappa Y, Schmidt BA, Di Germanio C, Rizvi N, Liu H, Ma ZM, Stone M, Simmons G, Dumont LJ, Allen AM, Lockwood S, Pollard RE, Ramiro de Assis R, Yee JL, Nham PB, Ardeshir A, Deere JD, Jain A, Felgner PL, Coffey LL, Iyer SS, Hartigan-O'Connor DJ, Busch MP, Reader JR
Early post-infection treatment of SARS-CoV-2 infected macaques with human convalescent plasma with high neutralizing activity had no antiviral effects but moderately reduced lung inflammation

2022
Evans TS, Aung O, Cords O, Coffey LL, Wong T, Weiss CM, Maw MT, Yee J, Venkateswaran K, Venkateswaran N, Nham P, Van Rompay KKA, Morris MK, Oceguera L, Werthimer W, Hanson C, Valitutto M, Tun KYN, Win YT, Thein WZ, Murray S, Thu HM, Johnson CK
Sylvatic Transmission of Chikungunya Virus among Nonhuman Primates in Myanmar

2022
Ball EE, Pesavento PA, Van Rompay KKA, Keel MK, Singapuri A, Gomez-Vazquez JP, Dudley DM, O'Connor DH, Breitbach ME, Maness NJ, Schouest B, Panganiban A, Coffey LL^
Zika virus persistence in the male macaque reproductive tract