Laura Stewart Van Winkle

Professor and Professor in Residence

Anatomy, Physiology & Cell Biology

Phone Number

+1 530 754 7547

Office

508 CHE, Davis, CA 95616

Licenses

Diplomate American Board of Toxicology (General Toxicology)

Education

1987, BS, University of California, Santa Barbara

1995, PhD, University of California, Davis

Active Research Grants

Co-Investigator, UC Davis Core Center in Environmental Health Sciences, Hertz-Piccioto (Principal Investigator), NIEHS

Co-Investigator, Human Cyp2A and respiratory tract xenobiotic toxicity, Xinxin Ding (Principal Investigator), NCI

Co-Investigator, Air Pollution, Atherosclerosis, and the Role of the Aryl Hydrocarbon Receptor, Christoph Vogel (Principal Investigator), NIH/NIEHS

Principal Investigator, Metabolic Mechanisms of Naphthalene toxicity in Lung, (Principal Investigator), NIH/NIEHS/NHLBI

Co-Investigator, What is the local dose of smoke from emerging tobacco products?, Wexler (Principal Investigator), Tobacco Related Diseases Research Program (TRDRP)

Principal Investigator, Traffic-related air pollution exacerbates AD-relevant phenotypes in a genetically susceptible rat model via neuroinflammatory mechanism(s) , (Principal Investigator), NIH

Co-Investigator, In vivo mechanistic study of QAC-induced pulmonary toxicity via mitochondrial injury, Cortopassi (Principal Investigator), NIH/NIEHS

Research Focus

The role of sex-differences and xenobiotic metabolism in lung pathology and toxicology. Air pollution including tobacco smoke, particulates and ozone. Growth factors and cell-cell interactions in lung wound healing, in lung disease (lung cancer and asthma) and during lung development. Cell proliferation and progenitor cells. Microscopes and imaging methods.

Specialty Focus

Toxicology of the lung. Diplomate American Board of Toxicology (DABT)

Ten Recent Publications

2023
Stevens NC, Brown VJ, Domanico MC, Edwards PC, Van Winkle LS, Fiehn O.
Alteration of glycosphingolipid metabolism by ozone is associated with exacerbation of allergic asthma characteristics in mice.

2023
Ding X, Han J, Van Winkle LS, Zhang QY
Detection of Transgene Location in the CYP2A13/2B6/2F1-transgenic Mouse Model using Optical Genome Mapping Technology.

2022
Kovalchuk N, Jilek JL, Van Winkle LS, Cherrington NJ, Ding X
Role of Lung P450 Oxidoreductase in Paraquat-Induced Collagen Deposition in the Lung.

2022
Cosert KM, Kim S, Jalilian I, Chang M, Gates BL, Pinkerton KE, Van Winkle LS, Raghunathan VK, Leonard BC, Thomasy SM
Metallic Engineered Nanomaterials and Ocular Toxicity: A Current Perspective.

2022
Huynh H, Upadhyay P, Lopez CH, Miyashiro MK, Van Winkle LS, Thomasy SM, Pinkerton KE
Inhalation of Silver Silicate Nanoparticles Leads to Transient and Differential Microglial Activation in the Rodent Olfactory Bulb.

2022
Kelty JS, Kovalchuk N, Uwimana E, Yin L, Ding X, Van Winkle LS^
In vitro airway models from mice, rhesus macaques, and humans maintain species differences in xenobiotic metabolism and cellular responses to naphthalene.

2022
Domanico M, Fukuto A, Tran LM, Bustamante JM, Edwards PC, Pinkerton KE, Thomasy SM, Van Winkle LS^
Cytotoxicity of 2D engineered nanomaterials in pulmonary and corneal epithelium.

2021
Fukuto A, Kim S, Kang J, Gates BL, Chang MW, Pinkerton KE, Van Winkle LS, Kiuchi Y, Murphy CJ, Leonard BC, Thomasy SM
Metal Oxide Engineered Nanomaterials Modulate Rabbit Corneal Fibroblast to Myofibroblast Transformation.

2021
Stevens NC, Edwards PC, Tran LM, Ding X, Van Winkle LS, Fiehn O
Metabolomics of Lung Microdissections Reveals Region- and Sex-Specific Metabolic Effects of Acute Naphthalene Exposure in Mice.

2021
Kim S, Gates BL, Chang M, Pinkerton KE, Van Winkle L, Murphy CJ, Leonard BC, Demokritou P, Thomasy SM
Transcorneal delivery of topically applied silver nanoparticles does not delay epithelial wound healing.