Laura Van Winkle

Laura Van Winkle

Professor and Professor in Residence

Anatomy, Physiology & Cell Biology

508 CHE, Davis, CA 95616

Diplomate American Board of Toxicology (General Toxicology)
1987, BS, University of California, Santa Barbara
1995, PhD, University of California, Davis
Active Research Grants
Principal Investigator, Metabolic mechanisms of naphthalene toxicity in lung, (Principal Investigator), NIH/NIEHS/NHLBI
Co-Investigator, UC Davis Core Center in Environmental Health Sciences, Hertz-Piccioto (Principal Investigator), NIEHS
Principal Investigator, ViCTER Supplement to R01 Metabolic mechanisms of naphthalene toxicity in lung, (Principal Investigator), NIEHS/NHLBI
Principal Investigator, Respiratory and Ocular Toxicity of Inhaled Nanomaterials, (Principal Investigator), NIEHS
Co-Investigator, Human Cyp2A and respiratory tract xenobiotic toxicity, Ding (Principal Investigator), NCI
Co-Investigator, ViCTER Supplement to Molecular and Cellular Basis of PCB Developmental Neurotoxicity, Lein/Pessah (Principal Investigator), NIEHS
Principal Investigator, Acquisition of a CytoViva Hyperspectral microscopy system, (Principal Investigator), NIH
Principal Investigator, Evaluation of the Effect of Chloropicrin on the Lungs of Mice, (Principal Investigator), Chloropicrin Manufacturers Association
Honors and Awards
1992-1993 Graduate Fellowship in Environmental Health Sciences
1993-1995 NIEHS Training Fellowship in Environmental Toxicology
1994 Robert Emrie Smith Memorial Research Fellowship in Physiology
1995-1997 NHLBI Pulmonary Postdoctoral Training Fellowship
1997-1999 American Lung Association Research Fellow
Most Recent Five Book Chapters
2018 Ding X, Li L, Van Winkle LS, Zhang Q.-Y : Biochemical Function of the Respiratory Tract: Metabolism of Xenobiotics , , Comprehensive Toxicology, Third Edition, McQueen, CA. 171-179.
2018 Van Winkle LS, Kelty JS, Smiley-Jewell S, Pinkerton KE : Tracheobronchial Airways, , Comprehensive Toxicology, Third Edition, . 29-49.
2018 Van Winkle LS, Carratt SA : Cell Damage and Cell Renewal in the Lung, , Comprehensive Toxicology- Respiratory Toxicology, Third Edition, McQueen, CA. 130-146.
2015 Pinkerton KE, Van Winkle LS, Plopper CG, Smiley-Jewell S, Covarrubias EC, McBride JT : Architecture of the Tracheobronchial Tree, Parent (ed): Pinkerton, Van Winkle, Plopper eds section 1, , Comparative Biology of Normal Lung, 2nd edition, . .
2010 Van Winkle LS : Cell damage and cell renewal in the lung, Yost et al, (ed), Toxicology of the Respiratory System, Comprehensive Toxicology, 2nd Edition, . .
Research Focus
The role of sex-differences and xenobiotic metabolism in lung pathology and toxicology. Air pollution including tobacco smoke, particulates and ozone. Growth factors and cell-cell interactions in lung wound healing, in lung disease (lung cancer and asthma) and during lung development. Cell proliferation and progenitor cells. Microscopes and imaging methods.
Specialty Focus
Toxicology of the lung. Diplomate American Board of Toxicology (DABT)
Ten Recent Publications

Kovalchuk N, Kelty J, Li L, Hartog M, Zhang QY, Edwards P, Van Winkle L, Ding X
Impact of hepatic P450-mediated biotransformation on the disposition and respiratory tract toxicity of inhaled naphthalene

Li L, Carratt S, Hartog M, Kovalchik N, Jia K, Wang Y, Zhang QY, Edwards P, Van Winkle L, Ding X
Human CYP2A13 and CYP2F1 Mediate Naphthalene Toxicity in the Lung and Nasal Mucosa of CYP2A13/2F1-Humanized Mice

Patchin ES, Anderson DS, Silva RM, Uyeminami DL, Scott GM, Guo T, Van Winkle LS, Pinkerton KE
Size-Dependent Deposition, Translocation, and Microglial Activation of Inhaled Silver Nanoparticles in the Rodent Nose and Brain

Carratt SA, Morin D, Buckpitt AR, Edwards PC, Van Winkle LS
Naphthalene cytotoxicity in microsomal epoxide hydrolase deficient mice.

Silva RM, Anderson DS, Peake J, Edwards PC, Patchin ES, Guo T, Gordon T, Chen LC, Sun X, Van Winkle LS, Pinkerton KE
Aerosolized Silver Nanoparticles in the Rat Lung and Pulmonary Responses over Time.

Holland NA, Becak DP, Shannahan JH, Brown JM, Carratt SA, Van Winkle LS, Pinkerton KE, Wang CM, Musamy P, Baer DR, Sumner SJ, Fennell TR, Lust RM, Wingard CJ
Cardiac ischemia reperfusion injury following instillation of 20nm citrate-capped nanosilver

Anderson DS, Patchin ES, Silva RM, Uyeminami DL, Sharmah A, Guo T, Das GK, Brown JM, Shannahan J, Gordon T, Chen LC, Pinkerton KE, Van Winkle LS
Influence of particle size on persistence and clearance of aerosolized silver nanoparticles in the rat lung.

Anderson DS, Silva RM, Lee D, Edwards PC, Sharmah A, Guo T, Pinkerton KE, Van Winkle LS
Persistence of silver nanoparticles in the rat lung: Influence of dose, size, and chemical composition.