My research focuses on the neuro-immune interactions at the blood-brain barrier (BBB) as a relevant contributor to neuropathogenesis and neuroinflammation, towards finding non-immunosuppressive therapeutic targets. Secondly, I aim to elucidate if focal alterations to BBB homeostasis are a sufficient predisposition to neuropathology, as opposed to the notion of a global BBB disruption as triggering factor for neuroinflammation. Third, the assessment of non-genetic triggering factors, including environmental exposure, nutrition, stress, etc. that cause BBB disruption through epigenetic modification of the neurovascular unit.