Lillian Cruz-Orengo

Associate Professor

Anatomy, Physiology & Cell Biology

1089 Veterinary Medicine Dr. 2019 VM3b, Davis, CA 95616

2005, PhD, University of Puerto Rico, Medical Sciences Campus, San Juan, Puerto Rico
1988, B.S., University of Puerto Rico, Rio Piedras Campus, San Juan, Puerto Rico
2013, Washington University, School of Medicine, Saint Lous, MO
Research Focus
My research focuses on the neuro-immune interactions at the blood-brain barrier (BBB) as a relevant contributor to neuropathogenesis and neuroinflammation, towards finding non-immunosuppressive therapeutic targets. Secondly, I aim to elucidate if focal alterations to BBB homeostasis are a sufficient predisposition to neuropathology, as opposed to the notion of a global BBB disruption as triggering factor for neuroinflammation. Third, the assessment of non-genetic triggering factors, including environmental exposure, nutrition, stress, etc. that cause BBB disruption through epigenetic modification of the neurovascular unit.
Specialty Focus
Neuroimmunology, Neuroinflammation, Brain Barriers, Molecular Neuroscience, Autoimmunity
Ten Recent Publications

Dayton JR, Yuan Y, Pacumio LP, Dorflinger BG, Yoo SC, Olson MJ, Hernández SI, McMahon MM, Cruz-Orengo L^
Expression of IL-20 Receptor Subunit Beta is Linked to EAE Neuropathology and CNS Neuroinflammation

Yuan Y, Dayton JR, Fresse ML, Dorflinger BG, Cruz-Orengo L^
Reliable Isolation of Central Nervous System Microvessels Across Five Vertebrate Groups

Brien JD, Hassert M, Stone ET, Geerling E, Cruz-Orengo L, Pinto AK
Isolation and Quantification of Zika Virus from Multiple Organs in a Mouse

Rodriguez RL, Albeck JG, Taha AY, Ori-McKenney KM, Recanzone GH, Stradleigh TW, Hernandez BC, Tang F-Y V, Chiang E-P I, Cruz-Orengo L
Impact of Diet-derived Signaling Molecules on Human Cognition: Exploring the Food-Brain Axis

Cruz-Orengo L, Daniels BP, Dorsey D, Basak SA, Grajales-Reyes JG, McCandless EE, Piccio L, Schmidt RE, Cross AH, Crosby SD, Klein RS
Enhanced sphingosine-1-phosphate receptor 2 expression underlies female CNS autoimmunity susceptibility.