Peter Havel


Molecular Biosciences

3426 Meyer Hall, Davis, CA 95616

1988, BS, University of Washington, Seattle, WA
1994, DVM, University of California, School of Veterinary Medicine, Davis
1994, PhD, University of California, Davis
Active Research Grants
Co-Principal Investigator, Mouse Metabolic Phenotyping Center (MMPC) At UC Davis, Lloyd (Principal Investigator), NIH/NIDDK
Principal Investigator, Exposure to Near Roadway Traffic Related Air Pollution (TRAP), Inflammation and Diabetes Onset in the UCD-T2DM Rat Model of Type-2 Diabetes, (Principal Investigator), UC, Davis NIEHS Environmental Health Science Center
Principal Investigator, Hypotriglyceridemic Effects of Furan Fatty Acids (FuFAs) in Fish Oils and Omega-3 Fatty Acid Products in Rhesus Macaques , (Principal Investigator), STAIR Grant from UC, Davis Office of Research
Co-Investigator, Soft drusen in rhesus macaques as a nonhuman primate model of early age-related macular degeneration, Glenn Yiu (Principal Investigator), National Eye Institute - NIH
Co-Investigator, The effects of orange juice compared with sugar-sweetened beverage on risk factors and metabolic processes associated with the development of cardiovascular disease and type 2 diabetes, Kimber Stanhope (Principal Investigator), NIH-NHLBI
Honors and Awards
1989-1990 New Investigator Travel Awards, The Endocrine Society
Most Recent Five Book Chapters
2016 Keim NL, Stanhope KL, Havel PJ^: Fructose and High Fructose Corn Syrup, Caballero B, Finglas P, Toldra F, (ed), The Encyclopedia of Food and Health, . 119-124.
2016 Stanhope KL, Havel PJ^: Effects and Mechanisms of Fructose-Containing Dietary Sugars in the Pathophysiology of Metabolic Syndrome, Bergeron N, Siri-Tarino P, Bray GA, Krauss RM, (ed), Nutrition and Cardiometabolic Health, 1st edition, . 251-74.
2014 Stanhope KL, Havel PJ^: Chapter 19: Mechanisms by which Dietary Sugars Influence Lipid Metabolism, Circulating Lipids and Lipoproteins, and Cardiovascular Risk, Goran MI, Tappy L, Le KA, (ed), Dietary Sugars and Health, Boca Raton, FL. 265-380.
2014 Keim NL, Levin RJ, Havel PJ^: Chapter 2: Carbohydrates, Ross AC, Caballero B, Cousins RJ, Tucker KL, Ziegler TR, (ed), Modern Nutrition in Health and Disease, 11th Edition, Baltimore, MD. 36-57.
2011 Havel PJ, Bremer AA: Chapter 7: Endocrine Regulation of energy Homeostasis: Implications for Obesity and diabetes, Ríos MS, Ordovás JM, Gutiérrez-Fuentes JA, (ed), Obesity, . 107-126.
Research Focus
Nutrition, Metabolism, Integrative Physiology, Endocrinology, and Pharmacology.

Application of physiological, biochemical, and molecular approaches for the investigation of endocrine function and the clinical syndromes diabetes and obesity, and cardiovascular disease.

Pharmacological treatment of diabetes, obesity, and cardiovascular disease
Specialty Focus
Physiology and pathophysiology of pancreatic, gastrointestinal and adipocyte hormones, carbohydrate and lipid metabolism in humans and animals, including clinical research and studies in nonhuman primate and rodent models of obesity, diabetes and cardiovascular disease and molecular/biochemical studies using in vitro systems.

Pharmacological and nutritional prevention and treatment of diabetes and obesity, CVD and fatty liver disease (NAFLD/NASH).
Ten Recent Publications

Edwards MM, Nguyen HK, Dodson AD, Herbertson AJ, Wietecha TA, Wolden-Hanson T, Graham JL, Honeycutt MK, Slattery JD, O'Brien KD, Havel PJ, Blevins JE
Effects of Combined Oxytocin and Beta-3 Receptor Agonist (CL 316243) Treatment on Body Weight and Adiposity in Male Diet-Induced Obese Rats

Koike S, Hsu M, Bettaieb A, Chu B, Matsumoto N, Morisseau C, Havel PJ, Huising MO, Hammock BD, Haj FG
Genetic deficiency or pharmacological inhibition of soluble epoxide hydrolase ameliorates high fat diet-induced pancreatic ß-cell dysfunction and loss

Mazi TA, Borkowski K, Newman JW, Fiehn O, Bowlus CL, Sarkar S, Matsukuma K, Ali MR, Kieffer DA, Wan YY, Stanhope KL, Havel PJ, Medici V
Ethnicity-specific alterations of plasma and hepatic lipidomic profiles are related to high NAFLD rate and severity in Hispanic Americans: A pilot study

Edwards MM, Nguyen HK, Herbertson AJ, Dodson AD, Wietecha T, Wolden-Hanson T, Graham JL, O'Brien KD, Havel PJ, Blevins JE
Chronic hindbrain administration of oxytocin elicits weight loss in male diet-induced obese mice.

Akther F, Razan MR, Shaligram S, Graham JL, Stanhope KL, Allen KN, Vázquez-Medina JP, Havel PJ, Rahimian R
Potentiation of Acetylcholine-Induced Relaxation of Aorta in Male UC Davis Type 2 Diabetes Mellitus (UCD-T2DM) Rats: Sex-Specific Responses.

Price CA, Medici V, Nunez MV, Lee V, Sigala DM, Benyam Y, Keim NL, Mason AE, Chen SY, Parenti M, Slupsky C, Epel ES, Havel PJ, Stanhope KL
A Pilot Study Comparing the Effects of Consuming 100% Orange Juice or Sucrose-Sweetened Beverage on Risk Factors for Cardiometabolic Disease in Women.

Mercer KE, Yeruva L, Pack L, Graham JL, Stanhope KL, Chintapalli SV, Wankhade UD, Shankar K, Havel PJ, Adams SH, Piccolo BD
Xenometabolite signatures in the UC Davis type 2 diabetes mellitus rat model revealed using a metabolomics platform enriched with microbe-derived metabolites.

Hieronimus B, Medici V, Bremer AA, Lee V, Nunez MV, Sigala DM, Keim NL, Havel PJ, Stanhope KL
Synergistic effects of fructose and glucose on lipoprotein risk factors for cardiovascular disease in young adults.

Butler AA, Graham JL, Stanhope KL, Wong S, King S, Bremer AA, Krauss RM, Hamilton J, Havel PJ^
Role of angiopoietin-like protein 3 in sugar-induced dyslipidemia in rhesus macaques: suppression by fish oil or RNAi.

Hui C, Tomilov A, Garcia C, Jiang X, Fash DM, Khdour OM, Rosso C, Filippini G, Prato M, Graham J, Hecht S, Havel P, Cortopassi G
Novel idebenone analogs block Shc's access to insulin receptor to improve insulin sensitivity.