Wayne Wei Feng

Project Scientist

Molecular Biosciences

Phone Number

+1 530 752 2174

Office

2213 VM3B, Davis, CA 95616

Education

1984, BA, Central China Univesity, Peoples Republic of China,

1987, MS, Institute of Hydrobiology, Peoples Republic of China,

1997, PhD, Ben-Gurion University, Israel,

Active Research Grants

Co-Investigator, Molecular Mechanisms of Marine Organohalogen Bioaccumulation and Neurotoxicity, Isaac Pessah (Principal Investigator), NSF - NIH/NIEHS

Instructor, Novel mechanisms for seizure mitigation and neuroprotection, Isaac Pessah (Principal Investigator), NIH/National Institute of Neurological Disorders and Stroke

Honors and Awards

1996 Award of Zlowtovtsky Neuroscience Foundation, Israel.

1991 Third Award, Achievements in Sciences and Technology, The Ministry of Agriculture of P.R. China No. 911885

1990 Second Award, Academy Award, The Chinese Academy of Fishery Sciences No 90-ykc-2-06-13

Most Recent Five Book Chapters

2002 Feng W and Pessah IN: Detection of redox sensor of ryanodine receptor complexes, C.K. Son and L. Packer, (ed), Methods in Enzymology, . 240-253.

1998 Shoshan-Barmatz V, Feng W: Chemical modification of ryanodine receptor/Ca2+ release channel activity, Sitsapesan R, Williams AJ, (ed), The Structure and Function of Ryanodine Receptors, Landes BioScience, Austin, Texas. 203-226.

1994 Wang WJ, Feng W, Li LX, Yu Y, Liu JX, Yao WJ, Xiao CX, Wang GT, Feng S: Parasitic infection state of fishes and its impact on the fishery in Wuling Mountain (In Chinese, translation not available), , Resources and Evaluation of Animal Species in Wuling Mountain Area of Southwest China, China. 98-114.

1993 Feng W, Wang WJ: Parasitic cestodes in freshwater fishes from Wuling mountain area In Chinese, translation not available), , Invertebrates in Wuling Mountain Area, China. 235-239.

1993 Feng W, Wang WJ: New digenetic trematodes of fishes in Wuling Mountain area (In Chinese, translation not available), , Invertebrates in Wuling Mountain Area, China. 223-234.

Research Focus

Molecular and bipphysical aspects reveling structure and function of ion channels, especially ryanodine receptors with associated proteins in mammalian skeletal, cardiac muscles and brain; Molecular mechamisms of genetic and environmental influences on cellular Ca2+ signaling.

Specialty Focus

Ion channels, Biochemistry and Biophysics.

Ten Recent Publications

2019
Zheng J, Yu Y, Feng W, Li J, Liu J, Zhang C, Dong Y, Pessah IN, Cao Z
Influence of Nanomolar Deltamethrin on the Hallmarks of Primary Cultured Cortical Neuronal Network and the Role of Ryanodine Receptors

2019
Sethi S, Morgan RK, Feng W, Lin Y, Li X, Luna C, Koch M, Bansal R, Duffel MW, Puschner B, Zoeller RT, Lehmler HJ, Pessah IN, Lein PJ
Comparative Analyses of the 12 Most Abundant PCB Congeners Detected in Human Maternal Serum for Activity at the Thyroid Hormone Receptor and Ryanodine Receptor

2019
Zheng J, Chen J, Zou X, Zhao F, Guo M, Wang H, Zhang T, Zhang C, Feng W, Pessah IN, Cao Z
Saikosaponin d causes apoptotic death of cultured neocortical neurons by increasing membrane permeability and elevating intracellular Ca2+ concentration

2018
Zheng J, McKinnie SMK, El Gamal A, Feng W, Dong Y, Agarwal V, Fenical W, Kumar A, Cao Z, Moore BS, Pessah IN
Organohalogens Naturally Biosynthesized in Marine Environments and Produced as Disinfection Byproducts Alter Sarco/Endoplasmic Reticulum Ca2+ Dynamics

2018
Li X, Holland EB, Feng W, Zheng J, Dong Y, Pessah IN, Duffel MW, Robertson LW, Lehmler HJ
Authentication of synthetic environmental contaminants and their (bio)transformation products in toxicology: polychlorinated biphenyls as an example.

2017
Feng W, Zheng J, Robin G, Dong Y, Ichikawa M, Inoue Y, Mori T, Nakano T, Pessah IN
Enantioselectivity of 2,2',3,5',6-Pentachlorobiphenyl (PCB 95) Atropisomers toward Ryanodine Receptors (RyRs) and Their Influences on Hippocampal Neuronal Networks.

2017
Holland EB, Feng W, Zheng J, Dong Y, Li X, Lehmler HJ, Pessah IN
An extended structure-activity relationship of non-dioxin-like PCBs evaluates and supports modeling predictions and identifies picomolar potency of PCB 202 towards ryanodine receptors

2016
Ronjata M, Feng W, Dardeveta L, Dong Y, Al Khourya S, Chatelaind FC, Viallaa V, Chahbouna S, Lesaged F, Darbong H, Pessah IN, De Waarda M
In cellulo phosphorylation induces pharmacological reprogramming of maurocalcin, a cell-penetrating venom peptide

2013
Niknam Y, Feng W, Cherednichenko G, Dong Y, Joshi SN, Vyas SM, Lehmler HJ, Pessah IN
Structure-activity relationship of selected meta- and para-hydroxylated non-dioxin like polychlorinated biphenyls: from single RyR1 channels to muscle dysfunction