Pamela J Lein
Department Chair and Professor
Department Chair and Professor
Molecular Biosciences
Molecular Biosciences
Phone Number
Office
2009 Vet Med 3B, Davis, CA 95616
Research Profile
Education
1992, Postdoctoral training, Roswell Park Cancer Institute, Buffalo, NY
1990, PhD, State University of New York at Buffalo, Buffalo, NY
1983, MS, East Tennessee State University, Johnson City, TN
1981, BS, Cornell University, Ithaca, NY
Active Research Grants
Principal Investigator, Investigating the cellular and molecular mechanisms of lower-chlorinated polychlorinated biphenyl developmental neurotoxicity, (Principal Investigator), NIH/NIEHS
Principal Investigator, Do atmospheric ultrafine particles lodge in the brain and cause cognitive decline leading to Alzheimer, (Principal Investigator), NIH/NINDS
Principal Investigator, UC Davis CounterACT Center of Excellence Developing Therapeutic Strategies for Mitigating the Chronic, (Principal Investigator), NIH/NINDS
Principal Investigator, Traffic-related air pollution exacerbates AD-relevant phenotypes in a genetically susceptible rat model via neuroinflammatory mechanism(s) , (Principal Investigator), NIH/NIA
Principal Investigator, Molecular and Cellular Basis of PCB Developmental Neurotoxicity, (Principal Investigator), NIH/NIEHS
Principal Investigator, NFP--Diversity Supplement to UC Davis CounterACT Center of Excellence: Role of IL-1ß in mediating the chronic adverse neurological effects of acute organophosphate intoxication, (Principal Investigator), NIH/NINDS
Principal Investigator, Diversity Supplement to UC Davis CounterACT Center of Excellence: The role of the JAK/STAT signaling pathway in chronic neurological effects of acute organophosphate intoxication, (Principal Investigator), NIH/NINDS
Principal Investigator, Diversity Supplement toTraffic-related air pollution exacerbates AD-relevant phenotypes in a genetically susceptible rat model via neuroinflammatory mechanism(s), (Principal Investigator), NIH/NIA
Honors and Awards
1987-1990 March of Dimes Predoctoral Fellowship
1991 NIH NCI National Research Service Award, Cell biology of human TILs engrafted into SCID mice (1F32 CA09177-01)
1994 National Science Foundation Research Opportunity Award, $10,000
1994-1997 Grass Fellowship Exchange, The Grass Foundation, $6,000
1995-1996 Dean's Grant, Arts and Sciences, Canisius College, $5000
1996-1999 Howard Hughes Medical Institute Program for Undergraduate Science Education, Co-PI, $650,000
1998-1999 NSF ILI grant, Incorporation of imaging techniques into undergraduate cell and molecular laboratories (DUE-9850762, PI, $26,297
2014 Lesiak A, Zhu M, Chen H, Appleyard SM, Impey S, Lein PJ*, Wayman GA (2014) * Corresponding author. The environmental neurotoxicant PCB 95 promotes synaptogenesis via ryanodine receptor-dependent miR132 upregulation. J Neurosci 34(3): 717-25. This article was selected as the editor’s highlight for this issue.
2014 Yang D, Kania-Korwel I, Ghogha A, Chen H, Stamou M, Bose DD, Pessah IN, Lehmler HJ, Lein PJ (2014) PCB136 atropselectively alters morphometric and functional parameters of neuronal connectivity in cultured rat hippocampal neurons via ryanodine receptor-dependent mechanisms. Toxicol Sci 138(2):379-392. This article was selected as the editor’s highlight for this issue.
2015 Zoetis Award for Veterinary Research Excellence
2017 Chen H, Streifel KM, Singh V, Yang D, Mangini L, Wulff H, Lein PJ (2017) BDE-47 and BDE-49 inhibit axonal growth in primary rat hippocampal neuron-glia co-cultures via ryanodine receptor-dependent mechanisms. Toxicol Sci 156(2):375-386. An image from this article was featured on the cover of this issue.
2017 Siso S*, Hobson BA*, Harvey DJ, Bruun DA, Rowland DJ, Garbow JR, Lein PJ (2017) Spatiotemporal progression and remission of lesions in the rat brain following acute intoxication with diisopropylfluorophosphate. Toxicol Sci 157(2):330-341. *Co-first authors. This article was selected as the editor’s highlight for this issue.
2017 Hobson BA, Siso S, Rowland DJ, Harvey DJ, Bruun DA, Garbow JR, Lein PJ (2017) Longitudinal monitoring by magnetic resonance imaging reveals progressive brain injury in rats acutely intoxicated with diisopropylfluorophosphate. Toxicol Sci 157(2):342-353. PMC5458789 An image from this article was featured on the cover of this issue.
2017 Kania-Korwel I, Lukasiewicz T, Barnhart CD, Stamou M, Chung H, Kelly KM, Bandiera S, Lein PJ, Lehmler HJ (2017) Congener-specific disposition of chiral polychlorinated biphenyls in lactating mice and their offspring: Implications for PCB developmental neurotoxicity. Toxicol Sci 158(1):101-115. This article was selected as the editor’s highlight for this issue.
Most Recent Five Book Chapters
2024 Spencer PS, Lein PJ^: Neurotoxicity, Wexler P, (ed), Encyclopedia of Toxicology, 4th edition, Oxford, UK. 727-740.
2023 Lein PJ: Chapter 4: Ryanodine receptor-dependent mechanisms of PCB Developmental Neurotoxicity, Aschner M, Costa LG, Kodavanti PRS, (ed), Advances in Neurotoxicology: Neurotoxicity of Halogenated Organic Compounds, Amsterdam, Netherlands. 137-178.
2023 Badley JR, Wilson RJ, Werner AS, Smiley-Jewell SM, Lein PJ^: Chapter 2: The neurotoxicity of polychlorinated biphenyls (PCBs), Aschner M, Costa LG, Kodavanti PRS, (ed), Advances in Neurotoxicology: Neurotoxicity of Halogenated Organic Compounds, Amsterdam, Netherlands. 27-79.
2023 Keil-Stietz K, Lein PJ^: Chapter 8: Gene x environment interactions in autism, Lipinski RJ, Krauss RS, (ed), Current Topics in Developmental Biology: Gene-Environment Interactions in Birth Defects and Developmental Disorders, Amsterdam, Netherlands. 221-284.
2023 Panesar HK, Wilson RJ, Lein PJ^: Cellular and molecular mechanisms of PCB developmental neurotoxicity, Kostrzewa RM, (ed), Handbook of Neurotoxicity, 2nd edition, New York City, NY. 1197-1226.
Research Focus
Cellular and molecular mechanisms of neurotoxicology; gene x environment interactions in neurodevelopmental disorders and neurodegenerative diseases; medical countermeasures for acute intoxication with seizurogenic compounds
Specialty Focus
Neurotoxicology, neuropharmacology, neuroinflammation, neurodevelopmental disorders, neurodegenerative disease