Pamela J Lein

Department Chair and Professor

Molecular Biosciences

2009 Vet Med 3B, Davis, CA 95616

1992, Postdoctoral training, Roswell Park Cancer Institute, Buffalo, NY
1990, PhD, State University of New York at Buffalo, Buffalo, NY
1983, MS, East Tennessee State University, Johnson City, TN
1981, BS, Cornell University, Ithaca, NY
Active Research Grants
Co-Investigator, Perinatal DDT exposure causes insulin resistance in adult mice through impaired thermogenesis, Michele La Merrill (Principal Investigator), NIH/NIEHS
Co-Investigator, Phenotypic Characterization of Novel Models of Dup15q Syndrome, Jill Silverman (Principal Investigator), NIH/NINDS
Principal Investigator, Novel Anticonvulsant and Neuroprotective Therapies for TETS and OP Intoxication, (Principal Investigator), NIH/NINDS
Principal Investigator, Vascular Inflammation and Exosomes as Mediators in Aging and Dementia, (Principal Investigator), NIH/NIA
Principal Investigator, PCB Epigenomic Brain & Behavior Lasting Effects Study (PEBBLES), (Principal Investigator), NIH/NIEHS
Collaborator, The function of duplicated genes in human brain evolution and disease, Megan Dennis (Principal Investigator), NIH/Officer of the Director
Co-Investigator, Role of excess maternal intake linoleic acid intake on infant neurodevelopment, Ameer Taha (Principal Investigator), NIH/NICHD
Principal Investigator, Identifying Molecular Targets for the Proconvulsant Activity of TETS, (Principal Investigator), NIH/NINDS
Principal Investigator, Imaging biomarkers of early synaptic changes in a preclinical model of Alzheimer’s disease, (Principal Investigator), NIH/NIA
Principal Investigator, Inhibiting AD inflammation with a novel class of small molecule PAI-1 antagonists, (Principal Investigator), NIH/NIA
Principal Investigator, PCB-mediated dysbiosis of the gut microbiome: A missing link in PCB-mediated neurodevelopmental disorders?, (Principal Investigator), NIH/NIEHS
Principal Investigator, Ketogenic diet approaches to slow disease progression in a rat model of Alzheimer’s disease, (Principal Investigator), NIH/NIA
Honors and Awards
1987-1990 March of Dimes Predoctoral Fellowship
1991 NIH NCI National Research Service Award, Cell biology of human TILs engrafted into SCID mice (1F32 CA09177-01)
1994 National Science Foundation Research Opportunity Award, $10,000
1994-1997 Grass Fellowship Exchange, The Grass Foundation, $6,000
1995-1996 Dean's Grant, Arts and Sciences, Canisius College, $5000
1996-1999 Howard Hughes Medical Institute Program for Undergraduate Science Education, Co-PI, $650,000
1998-1999 NSF ILI grant, Incorporation of imaging techniques into undergraduate cell and molecular laboratories (DUE-9850762, PI, $26,297
2010-2011 Vice President-Elect, Society of Toxicology (SOT) Neurotoxicology Specialty Section (NTSS)
2011-2012 Vice President, Society of Toxicology (SOT), Neurotoxicology Specialty Section (NTSS)
2012-2013 President, Society of Toxicology (SOT), Neurotoxicology Specialty Section (NTSS)
2013-2014 Past-President, Society of Toxicology (SOT), Neurotoxicology Specialty Section (NTSS)
2013-2014 Vice President, Society of Toxicology (SOT) Northern California Regional Chapter (NorCal SOT)
2014 Lesiak A, Zhu M, Chen H, Appleyard SM, Impey S, Lein PJ*, Wayman GA (2014) * Corresponding author. The environmental neurotoxicant PCB 95 promotes synaptogenesis via ryanodine receptor-dependent miR132 upregulation. J Neurosci 34(3): 717-25. This article was selected as the editor’s highlight for this issue.
2014 Yang D, Kania-Korwel I, Ghogha A, Chen H, Stamou M, Bose DD, Pessah IN, Lehmler HJ, Lein PJ (2014) PCB136 atropselectively alters morphometric and functional parameters of neuronal connectivity in cultured rat hippocampal neurons via ryanodine receptor-dependent mechanisms. Toxicol Sci 138(2):379-392. This article was selected as the editor’s highlight for this issue.
Most Recent Five Book Chapters
2019 Sethi S, Lein PJ : Chapter 11: The developmental neurotoxicity of polychlorinated biphenyls: A continuing environmental health concern, D’Mello JPF, (ed), A Handbook of Environmental Toxicology: Human Disorders and Ecotoxicology, Wallingford, Oxfordshire, United Kingdom. 156-172.
2019 Lein PJ, Fryer AD : Autonomic and enteric neurons: Cell culture, Stein J, (ed), Reference Module in Neuroscience and Biobehavioral Psychology, Oxford, UK. .
2019 Guignet M, Lein PJ : Chapter 2: Neuroinflammation in organophosphate-induced neurotoxicity, Aschner M, Costa LG, (ed), Advances in Neurotoxicology: Role of Inflammation in Environmental Neurotoxicity, volume 3 , Cambridge, MA. 35-79.
2018 Jett DA, Guignet M, Supasai S, Lein PJ: Chapter 16: Developmental toxicity within the cholinergic nervous system, Slikker W, Paule MG, Wang C, (ed), Handbook of Developmental Neurotoxicology, 2nd edition, Amsterdam. 183-198.
2018 Keil KP, Stamou M, Lein PJ: Chapter 22: Molecular mechanisms of neurotoxicity, Smart RC, Hodgson E, (ed), Molecular and Biochemical Toxicology, 5th edition, Somerset, NJ. 709-772.
Research Focus
Cellular and molecular mechanisms of neurotoxicology; gene x environment interactions in neurodevelopmental disorders and neurodegenerative diseases; medical countermeasures for acute intoxication with seizurogenic compounds
Specialty Focus
Neurotoxicology, neuropharmacology, neuroinflammation, neurodevelopmental disorders, neurodegenerative disease